Research Topics
Species | C DingSummaryAffiliation: University of Tasmania Country: Australia Publications
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Detail Information
Publications
Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studiesGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Australia
BMC Musculoskelet Disord 6:10. 2005..The aim of this study was to determine the optimal sampling of 1.5 mm thick slices of MRI scans to estimate knee cartilage volume in males and females for cross-sectional and longitudinal studies...- Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adultsDawn Dore
Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
Arthritis Res Ther 12:R222. 2010.... - Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adultsDawn Dore
Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
Arthritis Res Ther 12:R223. 2010.... - The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional studyOliver P Stannus
Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
Arthritis Res Ther 12:R95. 2010..The aim of this study was to describe the associations between leptin, IL-6, and hip radiographic osteoarthritis (ROA) in older adults... - Association between meniscal tears and the peak external knee adduction moment and foot rotation during level walking in postmenopausal women without knee osteoarthritis: a cross-sectional studyMiranda L Davies-Tuck
Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, 89 Commercial Road, Alfred Hospital, Melbourne, Victoria 3004, Australia
Arthritis Res Ther 10:R58. 2008..Joint loading mediated via gait parameters may be associated with meniscal tears, and determining whether such an association exists was the aim of this study... - Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair studyGuangju Zhai
Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia
Arthritis Res Ther 8:R137. 2006..They commonly coexist with chondral defects and ROA but only share common genetic mechanisms to a limited degree. They are also more common with increasing age, male sex, and increasing BMI... - Natural history of knee cartilage defects and factors affecting changeChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart
Arch Intern Med 166:651-8. 2006..Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history... - Anti-interleukin-6 receptor antibody treatment in inflammatory autoimmune diseasesChanghai Ding
Menzies Research Institute, Hobart, Tasmania, Australia
Rev Recent Clin Trials 1:193-200. 2006..Like other anti-cytokine immunotherapies, caution and close monitoring for the adverse events, especially infection, are necessary in subsequent clinical trials... - Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
J Rheumatol 34:776-84. 2007..To examine the associations between meniscal tear, knee structure, osteoarthritis (OA) risk factors, radiographic change, and symptoms in a largely non-osteoarthritic cohort... - Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKlineChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart 7000, Tasmania, Australia
Curr Opin Investig Drugs 7:464-72. 2006..By January 2006, belimumab had completed phase II clinical trials in SLE and RA; a phase III clinical SLE trial is scheduled to begin later this year... - A longitudinal study of the effect of sex and age on rate of change in knee cartilage volume in adultsChanghai Ding
Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
Rheumatology (Oxford) 46:273-9. 2007..To describe the association between sex, age and rate of change in knee cartilage volume in adults... - Two-year prospective longitudinal study exploring the factors associated with change in femoral cartilage volume in a cohort largely without knee radiographic osteoarthritisC Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
Osteoarthritis Cartilage 16:443-9. 2008..To identify factors associated with change in femoral cartilage volume over 2 years in a cohort largely without knee radiographic osteoarthritis... - Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndromeChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
Curr Opin Investig Drugs 7:1020-5. 2006..In June 2005, a phase II clinical trial of VX-702 was initiated in rheumatoid arthritis. In July 2006, Vertex was planning to file an IND in the second half of 2006... - ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseasesChanghai Ding
University of Tasmania, Menzies Research Institute, 199 Macquarie Street, Hobart, Tasmania 7000, Australia
Curr Opin Investig Drugs 9:515-22. 2008..ABT-87 was previously being developed for the potential treatment of multiple sclerosis; however, by May 2007, development for this indication was discontinued... - Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
J Clin Endocrinol Metab 93:1952-8. 2008..IL-1, IL-6, and TNF-alpha play an important role in the pathogenesis of osteoporosis in animals; however, evidence that these play a similar role in bone loss in human studies is limited... - Smoking interacts with family history with regard to change in knee cartilage volume and cartilage defect developmentChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 56:1521-8. 2007..To describe the effects of smoking on change in knee cartilage volume and increases in knee cartilage defects, and to test for interaction between smoking and family history of osteoarthritis (OA)... - Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) studyC Ding
Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
Ann Rheum Dis 67:1256-61. 2008..To describe the associations between leptin, body composition, sex and knee cartilage volume/defects in older adults... - How important is MRI for detecting early osteoarthritis?Changhai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
Nat Clin Pract Rheumatol 4:4-5. 2008 - B-cell-targeted therapy for systemic lupus erythematosus: an updateChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
BioDrugs 22:239-49. 2008..g. ocrelizumab) and agents that interrupt B-cell/T-cell interactions also have potential, and the efficacy of these, along with rituximab, belimumab and epratuzumab, needs to be determined by randomized controlled trials... - Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseasesChanghai Ding
University of Tasmania, Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
Expert Opin Biol Ther 8:1805-14. 2008..Belimumab (LymphoStat-B), a human monoclonal antibody that inhibits BlyS, was developed for the treatment of these diseases... - Not a simple fat-soluble vitamin: Changes in serum 25-(OH)D levels are predicted by adiposity and adipocytokines in older adultsC Ding
Menzies Research Institute, University of Tasmania, Hobart, TAS, Australia
J Intern Med 268:501-10. 2010..To determine the associations between body adiposity and change in serum 25-(OH)D levels over 2.6 years, and if these associations are mediated by metabolic and inflammatory factors in older adults... - Licofelone (Merckle)Changhai Ding
Menzies Centre for Population Health Research, University of Tasmania, Hobart 7000, Tasmania, Australia
IDrugs 6:802-8. 2003..EuroAlliance (a consortium of Alfa Wassermann SpA, Lacer SA and Merckle GmbH) is developing licofelone, a dual cyclooxygenase and 5-lipoxygenase inhibitor for the potential treatment of inflammatory disorders including osteoarthritis... - Bertilimumab Cambridge Antibody Technology GroupChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart 7000, Tasmania, Australia
Curr Opin Investig Drugs 5:1213-8. 2004..By September 2003, CAT had released results from phase I/II trials, and was seeking to outlicense rights for bertilimumab... - Knee and hip radiographic osteoarthritis predict total hip bone loss in older adults: a prospective studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
J Bone Miner Res 25:858-65. 2010..In conclusion, older subjects with radiographic hip and knee OA have higher total hip bone loss over 2.6 years regardless of symptoms, suggesting that consideration should be given to the monitoring of bone mass in these subjects... - Targeting IL-6 in the treatment of inflammatory and autoimmune diseasesChanghai Ding
Monash University, Central and Eastern Clinical School, Department of Epidemiology and Preventive Medicine, Commercial Road, Melbourne 3004, Australia
Expert Opin Investig Drugs 18:1457-66. 2009.... - Do NSAIDs affect longitudinal changes in knee cartilage volume and knee cartilage defects in older adults?Changhai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
Am J Med 122:836-42. 2009..The aim of this longitudinal study was to determine the associations between use of NSAIDs and changes in knee cartilage volume and knee cartilage defects over 2.9 years in older adults... - Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults: the Tasmanian older adult cohort studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania
Arthritis Rheum 60:1381-9. 2009..To determine the associations between serum levels of vitamin D, sunlight exposure, and knee cartilage loss cross-sectionally and longitudinally in older adults... - Technology evaluation: MRA, ChugaiChanghai Ding
Menzies Centre for Population Health Research, University of Tasmania, 17 Liverpool Street, Hobart, 7000 TAS, Australia
Curr Opin Mol Ther 5:64-9. 2003..MRA is currently undergoing phase II clinical trials for these indications... - Meniscal tear and increased tibial plateau bone area in healthy post-menopausal womenM L Davies-Tuck
Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Victoria 3004, Australia
Osteoarthritis Cartilage 16:268-71. 2008.... - The natural history of cartilage defects in people with knee osteoarthritisM L Davies-Tuck
Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, VIC 3004, Australia
Osteoarthritis Cartilage 16:337-42. 2008..The aim of this study was to examine the progression of cartilage defects over 2 years in people with knee OA and to identify factors associated with progression... - Association between age and knee structural change: a cross sectional MRI based studyC Ding
Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
Ann Rheum Dis 64:549-55. 2005..Longitudinal studies are needed to determine which of these changes are primary and confirm their relevance to knee OA... - Circulating levels of IL-6 and TNF-? are associated with knee radiographic osteoarthritis and knee cartilage loss in older adultsO Stannus
Menzies Research Institute, University of Tasmania, Hobart, Australia
Osteoarthritis Cartilage 18:1441-7. 2010..We determined the associations between serum levels of interleukin (IL)-6 and tumor necrosis factor-? (TNF-?), knee radiographic OA (ROA) and cartilage loss over 2.9 years in older adults... - Genetic mechanisms of knee osteoarthritis: a population based case-control studyG Jones
Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
Ann Rheum Dis 63:1255-9. 2004..To compare subjects who had at least one parent with a total knee replacement for severe primary knee osteoarthritis with age and sex matched controls who had no family history of knee osteoarthritis.. - Sex differences in knee cartilage volume in adults: role of body and bone size, age and physical activityC Ding
Menzies Centre for Population Health Research, University of Tasmania. Hobart, Australia
Rheumatology (Oxford) 42:1317-23. 2003..Further longitudinal studies in large samples will be required to confirm these findings... - A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibiaD Dore
Menzies Research Institute, University of Tasmania, Hobart, Australia
Osteoarthritis Cartilage 16:1539-44. 2008..To describe the reproducibility and validity of six different measurement techniques for knee subchondral bone mineral density (sBMD)... - Factors affecting progression of knee cartilage defects in normal subjects over 2 yearsY Wang
Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Vic. 3004, Australia
Rheumatology (Oxford) 45:79-84. 2006..Male gender and baseline cartilage defect score were the main factors associated with the progression of cartilage defects. Larger studies will be required to identify factors associated with the progression and regression of lesions... - Tibial subchondral bone size and knee cartilage defects: relevance to knee osteoarthritisC Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
Osteoarthritis Cartilage 15:479-86. 2007..Taken as a whole, these studies suggest that tibial subchondral bone expansion and cartilage defect development represent important targets for the prevention of cartilage loss and joint replacement... - A longitudinal study of the association between knee alignment and change in cartilage volume and chondral defects in a largely non-osteoarthritic populationGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Australia
J Rheumatol 34:181-6. 2007..We investigated whether baseline malalignment of the knee predicts subsequent change in knee cartilage volume and chondral defects in subjects with and without radiographic knee osteoarthritis (OA)... - The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair studyGuangju Zhai
Menzies Research Institute, University of Tasmania, Tasmania, Australia
Arthritis Rheum 52:2830-4. 2005.... - The associations between parity, other reproductive factors and cartilage in women aged 50-80 yearsS Wei
Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia
Osteoarthritis Cartilage 19:1307-13. 2011.... - Knee structural alteration and BMI: a cross-sectional studyChanghai Ding
Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
Obes Res 13:350-61. 2005..Preventing these changes may prevent knee osteoarthritis in overweight and obese subjects... - Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective studyFlavia Cicuttini
Department of Epidemiology and Preventive Medicine, Monash University Medical School, Alfred Hospital, Prahran, Victoria, Australia
Arthritis Rheum 52:2033-9. 2005..The aim of this study was to examine the association between cartilage defects in the knee and cartilage volume both cross-sectionally and longitudinally in healthy, middle-age adults... - The genetic contribution and relevance of knee cartilage defects: case-control and sib-pair studiesChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
J Rheumatol 32:1937-42. 2005..CONCLUSION: Knee cartilage defects are common, have a genetic component that is linked to the genetic contribution to knee pain and bone size, and may have a role in the genetic pathogenesis of knee OA... - Association of prevalent and incident knee cartilage defects with loss of tibial and patellar cartilage: a longitudinal studyChanghai Ding
University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 52:3918-27. 2005..Both increases and decreases in knee cartilage defects are associated with changes in knee cartilage volume, which implies a potential for reversal of knee cartilage loss... - The clinical correlates of articular cartilage defects in symptomatic knee osteoarthritis: a prospective studyA E Wluka
Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia
Rheumatology (Oxford) 44:1311-6. 2005..6, 22.3), independently of potential confounders. CONCLUSIONS: Articular cartilage defects are associated with disease severity in knee OA and predict patellar cartilage loss and knee replacement... - Factors associated with hip cartilage volume measured by magnetic resonance imaging: the Tasmanian Older Adult Cohort StudyGuangju Zhai
University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 52:1069-76. 2005..Furthermore, the generally stronger associations with volume compared with radiographic OA suggest that MRI may be superior at identifying risk factors for hip OA... - Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdownChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
Osteoarthritis Cartilage 13:198-205. 2005..Furthermore, knee cartilage defects may result in increased cartilage breakdown leading to decreased cartilage volume and joint space narrowing suggesting an important role for knee cartilage defects in early knee OA... - Subchondral bone and cartilage damage: a prospective study in older adultsDawn Dore
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 62:1967-73. 2010..The aim of this study was to describe the association between baseline tibial bone area and tibial subchondral bone mineral density (BMD) with tibial cartilage defect development and cartilage volume loss... - A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adultsDavid Scott
Menzies Research Institute, University of Tasmania, Hobart School of Human Life Sciences, University of Tasmania, Launceston, TAS, Australia
Clin Endocrinol (Oxf) 73:581-7. 2010..Our objective was to describe prospective associations between 25OHD, muscle parameters, and PA in community-dwelling older adults... - The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: a sibpair studyGuangju Zhai
University of Tasmania, Hobart, Tasmania, Australia
Arthritis Rheum 50:805-10. 2004..Cartilage volume, bone size, and muscle strength all have the potential to be studied in quantitative trait linkage analyses, but their exact relevance with regard to OA remains uncertain at this time... - Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and femalesG Jones
Menzies Centre for Population Health Research, GPO Box 252 23, Tasmania 7000, Hobart, Australia
Osteoarthritis Cartilage 12:169-74. 2004..To describe the association between early radiographic osteoarthritis of the knee (ROA), knee cartilage volume and tibial bone surface area... - Knee articular cartilage development in children: a longitudinal study of the effect of sex, growth, body composition, and physical activityGraeme Jones
Menzies Centre for Population Health Research, GPO Box 252 23, Hobart, Tasmania, Australia 7000
Pediatr Res 54:230-6. 2003..These results provide novel data on articular cartilage development in humans. The long-term significance of these results with regard to osteoarthritis of the knee in later life remains hypothetical... - What can we learn about osteoarthritis by studying a healthy person against a person with early onset of disease?Changhai Ding
Department of Epidemiology and Preventive Medicine, Monash University Medical School, Melbourne, Australia
Curr Opin Rheumatol 22:520-7. 2010..This review aims to examine the recent epidemiological and clinical evidences of early knee structural changes in the younger populations with relatively healthy knees... - Correlates of subchondral BMD: a cross-sectional studyDawn Dore
Menzies Research Institute, University of Tasmania, Hobart, Australia
J Bone Miner Res 24:2007-15. 2009..10, p < 0.01). In conclusion, this study identified a large number of factors associated with sBMD, of which the most novel is cartilage defects. Longitudinal studies are required to address causality... - Static knee alignment is associated with the risk of unicompartmental knee cartilage defectsNeela Janakiramanan
Department of Epidemiology and Preventative Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, VIC 3004, Australia
J Orthop Res 26:225-30. 2008.... - Physical activity and knee structural change: a longitudinal study using MRIStella Foley
Menzies Research Institute, University of Tasmania, Hobart, Australia
Med Sci Sports Exerc 39:426-34. 2007..Exercise therapy is effective in improving symptoms of knee osteoarthritis, but its effect on structural change remains unclear... - Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volumeChanghai Ding
Menzies Research Institute, University of Tasmania, 199 Macquarie Street, Hobart 7000, Australia
Arthritis Res Ther 9:R21. 2007.... - Genetic mechanisms of knee osteoarthritis: a population-based longitudinal studyChanghai Ding
Menzies Research Institute, University of Tasmania, Hobart, Australia
Arthritis Res Ther 8:R8. 2006..Importantly, the cartilage changes are largely dependent on baseline differences in cartilage volume, tibial bone area, BMI and knee pain, suggesting that these factors might have a role in their initiation... - Do NSAIDs affect the progression of osteoarthritis?Changhai Ding
Menzies Centre for Population Health Research, University of Tasmania, Australia
Inflammation 26:139-42. 2002..Therefore, it is necessary and valuable to clarify the effects of these NSAIDs on cartilage in patients with OA using validated non-invasive methods such as MRI... - Correlates of knee pain in younger subjectsGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Tasmania, 7001, Australia
Clin Rheumatol 26:75-80. 2007..MRI and biochemical measures can add to radiographs in defining unexplained knee pain in younger subjects... - Correlates of knee pain in older adults: Tasmanian Older Adult Cohort StudyGuangju Zhai
Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
Arthritis Rheum 55:264-71. 2006..The association between radiographic hip OA and knee pain indicates that referred pain from the hip needs to be considered in unexplained knee pain... - Radiographic osteoarthritis and pain are independent predictors of knee cartilage loss: a prospective studyJ Saunders
Menzies Research Institute, University of Tasmania, Hobart, Australia
Intern Med J 42:274-80. 2012..There is controversy about whether pain and radiographic osteoarthritis (ROA) predict subsequent cartilage loss. The aim of this study was to describe the relationship between ROA, pain and cartilage loss in the knee... - Association of baseline knee bone size, cartilage volume, and body mass index with knee cartilage loss over time: a longitudinal study in younger or middle-aged adultsBenny Antony
Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
J Rheumatol 38:1973-80. 2011..To determine the association of knee bone size, cartilage volume, and body mass index (BMI) at baseline with knee cartilage loss over 2 years in younger or middle-aged adults... - Does diclofenac induce accelerated progression of hip and knee radiographic osteoarthritis? Comment on the article by Reijman et alChanghai Ding
Arthritis Rheum 54:1027; author reply 1028. 2006 - Predictors of clinical response to intraarticular Hylan injections -- a prospective study using synovial fluid measures, clinical outcomes, and magnetic resonance imagingAnanthila Anandacoomarasamy
Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
J Rheumatol 35:685-90. 2008..To evaluate synovial fluid (SF) and clinical and imaging predictors of clinical response in patients receiving intraarticular Hylan GF-20 injections... - Leflunomide, a new disease-modifying drug for treating active rheumatoid arthritis in methotrexate-controlled phase II clinical trialChunde Bao
Department of Clinical Immunology, Shanghai Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
Chin Med J (Engl) 116:1228-34. 2003..To evaluate the efficacy and safety of leflunomide in comparison with methotrexate (MTX) on patients with rheumatoid arthritis (RA) in China... - Association of ACE gene polymorphism with genetic susceptibility to systemic lupus erythematosus in a Chinese population: a family-based association studyJianhua Xu
Department of Rheumatology, First Affiliated Hospital, Hefei, China
J Rheumatol 34:2408-11. 2007..Family-based association analysis was performed to investigate whether the angiotensin-converting enzyme (ACE)-G261T and ACE-A592G polymorphisms are risk factors for systemic lupus erythematosus (SLE) in a Chinese population...