Research Topics
Genomes and Genes | Brian DeanSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
Decreased kainate receptors in the hippocampus of apolipoprotein D knockout miceSimone Boer
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Australia
Prog Neuropsychopharmacol Biol Psychiatry 34:271-8. 2010....- Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorderBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Australia
J Affect Disord 120:245-8. 2010..Therefore we decided to determine whether TNF was altered in the frontal cortex (Brodmann's areas (BA) 24 and 46) from 10 subjects with MDD and 10 control subjects... - Recent advances in postmortem pathology and neurochemistry in schizophreniaBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Australia
Curr Opin Psychiatry 22:154-60. 2009..This is a review examining recent data from the study of the postmortem central nervous system (CNS) of patients with schizophrenia... - Is schizophrenia the price of human central nervous system complexity?Brian Dean
Rebecca L Cooper Research Laboratories, Mental Health Research Institute, Vic, Australia
Aust N Z J Psychiatry 43:13-24. 2009..Therefore there is evidence to support the hypothesis that schizophrenia is a disease that develops because of derangements to human-specific CNS functions that have emerged since our species diverged from non-human primates... - Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorderSimone Boer
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Victoria 3052, Australia
Neurosci Lett 466:27-9. 2009..These data suggest any change in NRG1Ialpha and NRG3 expression in schizophrenia or bipolar 1 disorder do not result in changes levels in levels of those proteins Brodmann's area 46... - Evidence for altered post-receptor modulation of the serotonin 2a receptor in schizophreniaBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Locked Bag 11, Parkville, 3052, Victoria, Australia
Schizophr Res 104:185-97. 2008.... - Evolution of the human CNS cholineric system: has this resulted in the emergence of psychiatric disease?Brian Dean
Mental Health Research Institute, Melbourne, Victoria, Australia
Aust N Z J Psychiatry 43:1016-28. 2009..Evidence is available to support the notion that the changes in functioning of the human CNS cholinergic system in individuals with psychiatric disorders may have resulted from both Darwinian and Lamarckian concepts of evolution... - Increased levels of serotonin 2A receptors and serotonin transporter in the CNS of neuregulin 1 hypomorphic/mutant miceBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Victoria, Australia
Schizophr Res 99:341-9. 2008..These data are the first evidence to suggest that NRG1 gene expression may be involved in regulating the development of the serotonergic system in the mammalian CNS... - Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studiesBrian Dean
Rebecca L Cooper Research Laboratories, Mental Health Research Institute, Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
Int J Neuropsychopharmacol 14:997-1012. 2011..Finally, it will be postulated how changes in these proteins affect CNS function to cause psychiatric disorders... - Levels of [(3)H]pirenzepine binding in Brodmann's area 6 from subjects with schizophrenia is not associated with changes in the transcription factor SP1 or BACE1Brian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Victoria, Australia
Schizophr Res 106:229-36. 2008..Our findings on BACE1 suggest that the schizophrenia phenotype reported in BACE(-/-) mice is not simply due to lack of that protein in the cortex... - Using differential solubilization and 2-D gel electrophoresis to visualize increased numbers of proteins in the human cortex and caudate nucleus and putamenBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Victoria, Australia Department of Psychiatry, Monash University, Clayton, Victoria, Australia Pathology, The University of Melbourne, Parkville, Monash University, Clayton, Victoria, Australia Department of Psychological Medicine, Monash University, Clayton, Victoria, Australia
Proteomics Clin Appl 2:1281-9. 2008.... - Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulationLaura Gray
Howard Florey Institute, University of Melbourne, Victoria, Australia
Int J Neuropsychopharmacol 12:45-60. 2009..These results highlight both the interactions between mGluR5 and NMDA receptors in the determination of schizophreniform behaviours and the potential for the effects of clozapine to be mediated by NMDA receptor regulation... - Sensitivity to MK-801 in phospholipase C-?1 knockout mice reveals a specific NMDA receptor deficitLaura Gray
Howard Florey Institute, University of Melbourne, Victoria, Australia
Int J Neuropsychopharmacol 12:917-28. 2009..These results also shed further light on the capacity of environmental factors to modulate subsets of these phenotypes... - Effects of benzodiazepine treatment on cortical GABA(A) and muscarinic receptors: studies in schizophrenia and ratsMark C McLeod
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Australia
Psychiatry Res 179:139-46. 2010..These data would therefore support our previously stated hypotheses that changes in the cortical cholinergic and GABAergic systems are involved in the pathophysiology of schizophrenia... - Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorderBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
Brain Res Mol Brain Res 138:145-55. 2005.... - Studies on serotonergic markers in the human hippocampus: changes in subjects with bipolar disorderBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
J Affect Disord 75:65-9. 2003..Various studies suggest the hippocampus and serotonergic systems are important in the pathology of bipolar disorder (BD). We therefore measured hippocampal serotonergic markers in post-mortem tissue from BD and control subjects... - Treatment with haloperidol and diazepam alters GABA(A) receptor density in the rat brainMark C McLeod
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Locked Bag 11, Parkville, Victoria, 3052, Australia
Prog Neuropsychopharmacol Biol Psychiatry 32:560-7. 2008..This outcome may be relevant to the therapeutic benefits of using both drugs in conjunction early in the treatment of a psychotic episode... - The heterogeneity of central benzodiazepine receptor subtypes in the human hippocampal formation, frontal cortex and cerebellum using [3H]flumazenil and zolpidemMark McLeod
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute, Locked Bag 11, Parkville, Victoria 3052, Australia
Brain Res Mol Brain Res 104:203-9. 2002..Moreover, our data suggests that the differential distribution of the zolpidem insensitive component of [3H]flumazenil binding is an indicator of GABA/BZ receptors assembled by different subunits within the human brain... - Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophreniaElizabeth Scarr
Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville, Vic, Australia
Biol Psychiatry 61:1161-70. 2007.... - No change in cortical muscarinic M2, M3 receptors or [35S]GTPgammaS binding in schizophreniaElizabeth Scarr
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
Life Sci 78:1231-7. 2006..Given the widespread changes in muscarinic receptors identified in the CNS of subjects of schizophrenia using functional neuroimaging it remains possible that receptors other than the M1 receptor may be altered in different CNS regions... - Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorderBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Australia
Psychiatry Res 158:75-8. 2008..Levels of apolipoprotein D were not changed by treatment. Hence changed apolipoprotein E could be involved in abnormalities in lipid homeostasis in some subjects with psychiatric diseases... - Cortical serotonin7, 1D and 1F receptors: effects of schizophrenia, suicide and antipsychotic drug treatmentBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, The University of Melbourne, Australia
Schizophr Res 88:265-74. 2006.... - Cortical glutamatergic markers in schizophreniaElizabeth Scarr
Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Australia
Neuropsychopharmacology 30:1521-31. 2005..These data indicate that the decreased number of kainate receptors in the dorsolateral prefrontal cortex in schizophrenia may result, in part, from reduced expression of the GluR5 receptor subunits... - Differential changes in apolipoprotein E in schizophrenia and bipolar I disorderAlison Digney
Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
Biol Psychiatry 57:711-5. 2005..This study extends an initial finding of increased levels of apoE in Brodmann's area (BA) 9 from subjects with schizophrenia to determine if apoE is altered in other brain regions and in brains from subjects with bipolar I disorder (BID)... - The neurobiology of APOE in schizophrenia and mood disordersAndrew Stuart Gibbons
Rebecca L Cooper Laboratories, Mental Health Research Institute of Victoria, Parkville, Victoria, Victoria 3052, Australia
Front Biosci 16:962-79. 2011..This review will summarise the current understanding of the involvement of APOE and its receptors in the symptomatology and pathology of schizophrenia and mood disorders and the implications of this involvement for drug treatment... - Region and diagnosis-specific changes in synaptic proteins in schizophrenia and bipolar I disorderLaura J Gray
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
Psychiatry Res 178:374-80. 2010..Our data support the notion that there are complex and region-specific alterations in presynaptic proteins that may lead to alterations in synaptic activity in both schizophrenia and bipolar disorder... - Serotonin 1a receptor and associated G-protein activation in schizophrenia and bipolar disorderLaura Gray
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia
Psychiatry Res 143:111-20. 2006..These data indicates that there may be subtle changes in serotonin 1a receptors across the cortex in schizophrenia or bipolar I disorder and suggests a gender discordance in receptor levels... - Gene expression profiling in Brodmann's area 46 from subjects with schizophreniaBrian Dean
Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Locked Bag 11, Parkville, VIC 3052, Australia
Aust N Z J Psychiatry 41:308-20. 2007..To identify altered gene expression in the dorsolateral prefrontal cortex obtained after death from subjects with schizophrenia... - CNS 14-3-3zeta: changes with sex but not psychiatric diagnoses or psychotropic drug treatmentBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Victoria, Australia
Schizophr Res 93:51-7. 2007..By contrast, our study suggests that levels of 14-3-3zeta in some regions of the human CNS may be modulated by some sex-specific mechanism... - Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophreniaBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, The University of Melbourne, Parkville, Victoria, Australia
Aust N Z J Psychiatry 40:217-24. 2006..To determine if levels of the glial-derived proteins S100beta and glial acidic fibrillary protein (GFAP) and the pro- and antiapoptotic proteins p53 and Bcl-2 were altered in the cortex of subjects with schizophrenia or bipolar 1 disorder... - Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illnessMadhara Udawela
Rebecca L Cooper Research Laboratories, Mental Health Research Institute, Parkville, Victoria, Australia
Aust N Z J Psychiatry 45:140-7. 2011..Thus we aimed to validate and extend these findings... - Role of muscarinic receptors in the activity of N-desmethylclozapine: reversal of hyperactivity in the phospholipase C knockout mouseLaura Gray
Howard Florey Institute, University of Melbourne, Victoria, Australia
Behav Pharmacol 19:543-7. 2008.... - [3H]RX 821002 in human dorsolateral prefrontal cortex: no changes in postmortem tissue from subjects with schizophreniaBrian Dean
Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Victoria, Parkville, Australia
Psychiatry Res 119:25-31. 2003.... - Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathologyAlex Fornito
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Schizophr Bull 35:973-93. 2009..We discuss the potential mechanisms that might facilitate integration of these findings and consider strategies for future research... - Cannabis-sensitive dopaminergic markers in postmortem central nervous system: changes in schizophreniaBrian Dean
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
Biol Psychiatry 53:585-92. 2003..Tyrosine hydroxylase was not different in any diagnostic cohort. CONCLUSIONS: Our data suggests that DAT is decreased in the caudate from THC(-) subjects with schizophrenia, a change that may be reversed by ingesting THC from cannabis... - Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophreniaAndrew Stuart Gibbons
Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville, Vic, Australia
Aust N Z J Psychiatry 42:740-5. 2008..The aim of the present study was to reconcile these discrepancies by examining RGS4 expression in the dorsolateral prefrontal and parietal cortices from subjects with schizophrenia... - Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophreniaBrian Dean
Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
Biol Psychiatry 54:616-22. 2003..It is unclear whether altered expression of a specific isoform of apolipoprotein E (apoE) is associated with the pathology of schizophrenia... - N-Ethylmaleimide sensitive factor in the cortex of subjects with schizophrenia and bipolar I disorderLaura Gray
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, 155 Oak St, Parkville, Victoria 3052, Australia
Neurosci Lett 391:112-5. 2006..These findings highlight the importance of validating findings from high-throughput screening studies and do not support changes in cortical NSF as being of significance in schizophrenia or bipolar 1 disorder... - Role of the cholinergic system in the pathology and treatment of schizophreniaElizabeth Scarr
Centre for Neuroscience, University of Melbourne, Parkville, Vic, Australia
Expert Rev Neurother 9:73-86. 2009.... - Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophreniaAdel Barakat
Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
Schizophr Res 124:200-7. 2010..671, p<0.001) but not in the schizophrenic groups. These data suggest that the proteolytic processing of NRG1 is impaired in schizophrenia... - Abnormal hippocampal distribution of TDP-43 in patients with-late onset psychosisDennis Velakoulis
Neuropsychiatry Unit, Royal Melbourne Hospital, Vic, Australia
Aust N Z J Psychiatry 43:739-45. 2009..A secondary objective was to identify clinicopathological relationships of any such abnormalities... - Decreased density of [3H]TCP binding following antipsychotic drug withdrawal in ratsElizabeth Scarr
The Molecular Schizophrenia Division, The Mental Health Research Institute of Victoria, Parkville, Australia
Life Sci 70:2699-705. 2002..1 mg/kg/day) for three months. These data suggest that changes in the NMDA receptor associated ion channels occur following antipsychotic drug withdrawal... - Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortexMargaret J Smith
Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Grattan St, Parkville, Victoria 3010, Australia
Brain Res Mol Brain Res 127:128-35. 2004..Our findings support previous evidence for increased expression of this variant PS2 isoform in sporadic AD and suggest this isoform may contribute to neurodegeneration... - Muscarinic receptors: do they have a role in the pathology and treatment of schizophrenia?Elizabeth Scarr
Rebecca L Cooper Research Laboratories, Mental Health Research Institute, Parkville, Vic, Australia
J Neurochem 107:1188-95. 2008..The body of evidence presented suggests that deficits in muscarinic receptors are associated with some forms of schizophrenia and that targeting these receptors could prove to be of therapeutic benefit to patients with the disorder... - Clozapine decreases [3H] CP 55940 binding to the cannabinoid 1 receptor in the rat nucleus accumbensSuresh Sundram
The Mental Health Research Institute of Victoria, Locked Bag 11, Parkville, Victoria, 3052, Australia
Naunyn Schmiedebergs Arch Pharmacol 371:428-33. 2005..If these results can be extrapolated into humans, then this effect of clozapine on the CB1 receptor may be a mechanism that makes it uniquely effective in schizophrenia and comorbid cannabis use... - The neurobiology of bipolar disorder: findings using human postmortem central nervous system tissueBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Locked Bag 11, Parkville, Victoria 3052, Australia
Aust N Z J Psychiatry 38:135-40. 2004..These studies, along with a limited number of functional neuroimaging studies, have been reviewed to provide information on the neurobiology underlying the disorder... - Evaluation of treatment in 35 cases of bipolar suicideNicholas A Keks
Mental Health Research Institute of Victoria, Melbourne, Victoria, Australia
Aust N Z J Psychiatry 43:503-8. 2009..The aim of the present study was to evaluate clinical factors relevant to suicide prevention (including treatment) in cases of bipolar suicide with available therapeutic histories... - AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorderAndrew Stuart Gibbons
Rebecca L Cooper Laboratories, Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
J Affect Disord 136:1232-7. 2012..Therefore, we sought to examine whether the expression of the non-NMDA, ionotropic glutamate receptors, AMPA receptor and kainate receptor, is altered in mood disorders... - Brain distribution of selected antipsychotics in schizophreniaKabrena E Rodda
Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University, 57-83 Kavanagh Street, Southbank, Vic. 3006, Australia
Forensic Sci Int 157:121-30. 2006..The regional brain distribution of thioridazine and its metabolites was concentration dependent. These results have implications for determining the role of these drugs in the sudden and unexpected deaths of schizophrenics... - The cortical serotonin2A receptor and the pathology of schizophrenia: a likely accompliceBrian Dean
The Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
J Neurochem 85:1-13. 2003..In particular, an argument will be developed that the changes in the 5HT2AR in schizophrenia are reflective of a real or perceived change in serotonergic tone and that this forms an important part of the pathology of the illness... - Low Density Lipoprotein Receptor-Related Protein and Apolipoprotein E Expression is Altered in SchizophreniaAndrew Stuart Gibbons
Rebecca L Cooper Laboratories, Mental Health Research Institute of Victoria Parkville, Vic, Australia
Front Psychiatry 1:19. 2010..Our data supports a role for distinct members of the LRP family in the pathology of schizophrenia and adds weight to the hypothesis that aberrant apolipoprotein signaling is involved in the early stages of schizophrenia... - Changes in the molecular structure of the brain in bipolar disorder: findings using human postmortem brain tissueBrian Dean
Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Locked Bag 11, Parkville, Victoria, 3052 Australia
World J Biol Psychiatry 3:125-32. 2002..Together these studies confirm that the pathology of bipolar disorder is complex but is yielding to intense study of the molecular architecture of postmortem brain tissue from subjects with the illness... - Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosisAvril Pereira
Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville 3052, Victoria, Australia
Biochem Pharmacol 72:783-93. 2006.... - High-resolution phosphor imaging: validation for use with human brain tissue sections to determine the affinity and density of radioligand bindingGeoffrey M Pavey
The Rebecca L Cooper Research Laboratories, Division of Molecular Schizophrenia, The Mental Health Research Institute of Victoria, Locked Bag 11, Parkville, VIC 3052, Australia
J Neurosci Methods 116:157-63. 2002..Moreover, the reduced exposure time of phosphor imaging plates (e.g. 7 days vs 5 weeks) allows results to be obtained more rapidly than with conventional film autoradiography... - [(3)H]Flumazenil binding in the human hippocampal formation, frontal cortex and cerebellum detected by high-resolution phosphorimagingMark McLeod
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute, Locked Bag 11, Parkville, Victoria, Australia
Brain Res 926:27-32. 2002....