Research Topics
Species | R A ClarkeSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Multiple sclerosis in a radiosensitive family with low levels of the ATM proteinRaymond A Clarke
Division of Cancer Services, The St George Hospital, University of New South Wales, Australia
Australas Radiol 46:267-74. 2002..In this study, we describe a case of MS in a family with cellular radiosensitivity and abnormally low postinduction levels of the ATM protein. Defective DNA repair/rejoining may impact on autoimmunity...
ATM induction insufficiency in a radiosensitive breast-cancer patientR A Clarke
Molecular Genetics Laboratories, Cancer Care Center, Division of Cancer Services, The St George Hospital and University of New South Wales, Australia
Australas Radiol 46:329-35. 2002..Postinduction ATM levels were up to tenfold lower in the patient's fresh tissues compared to normal controls. These results might indicate a much broader role for ATM anomalies in breast cancer aetiology...
Low levels of ATM in breast cancer patients with clinical radiosensitivityZhiming Fang
Department of Radiation Oncology, St George Clinical School of Medicine University of NSW, St George Hospital, Kogarah, NSW 2217, Australia
Genome Integr 1:9. 2010..The association of specific ATM gene mutations with these pathologies has been well documented, however, there is uncertainty regarding pathological thresholds for the ATM protein...
ATM protein synthesis patterns in sporadic breast cancerR Kairouz
Division of Cancer Services, St George Hospital, Kogarah, NSW, Australia
Mol Pathol 52:252-6. 1999..This study aimed to determine whether reduced synthesis of ATM was also an important factor in sporadic breast cancer...
Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated proteinZ M Fang
Department of Radiation Oncology, South Eastern Area Laboratory Service, St George Hospital, St George Clinical School, University of New South Wales, Kogarah, New South Wales, Australia
J Med Imaging Radiat Oncol 53:234-9. 2009..MMB requires close follow-up and aggressive treatment. If adjuvant radiotherapy is adopted to improve local control, minimal postoperative delay and higher doses than for standard post-mastectomy radiation are recommended...
Rapid radiation-induction of ATM protein levels in situZ M Fang
Division of Cancer Services, The St. George Hospital, University of NSW, Kogarah, Australia
Pathology 33:30-6. 2001..ATM radiation-induction is a sensitive and rapid radioprotective response that complements the IR mediated activation of ATM...
Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndromeMay Tassabehji
Academic Unit of Medical Genetics and Regional Genetics Service, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
Hum Mutat 29:1017-27. 2008....
