Research Topics
| R P AndersonSummaryAffiliation: The Walter and Eliza Hall Institute of Medical Research Country: Australia Publications
| Collaborators
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Detail Information
Publications
Coeliac disease: current approach and future prospectsR P Anderson
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute and Department of Gastroenterology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
Intern Med J 38:790-9. 2008..With greater awareness and non-dietary therapeutics, diagnosis and treatment of coeliac disease will be increasingly prominent in medical practice...- Coeliac diseaseRobert P Anderson
The Royal Melbourne Hospital
Aust Fam Physician 34:239-42. 2005..Heightened media interest in the negative effects of dietary gluten has led many patients to request testing for CD or follow inappropriate diets. Doctors have had little education in CD because of its perceived rarity... - Coeliac disease is on the riseRobert P Anderson
The Alfred Hospital, Melbourne, Vic, Australia
Med J Aust 194:278-9. 2011..An estimated four out of five Australians with coeliac disease are undiagnosed - we need greater awareness and increased testing... - Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac diseaseR P Anderson
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute, Department of Gastroenterology, The Royal Melbourne Hospital, Parkville, Victoria, Australia
Gut 55:485-91. 2006.... - T cells in peripheral blood after gluten challenge in coeliac diseaseR P Anderson
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute, c o Post Office RMH, Victoria, Australia 3050
Gut 54:1217-23. 2005..T cell clones allow identification of gluten peptides that stimulate T cells but do not quantify their contribution to the overall gluten specific T cell response in individuals with CD when exposed to gluten in vivo... - A systematic approach for comprehensive T-cell epitope discovery using peptide librariesTim Beissbarth
Walter and Eliza Hall Institute of Medical Research 1G Royal Parade, Australia
Bioinformatics 21:i29-37. 2005..We were interested in the study of celiac disease (CD) and used the ELISPOT technique to perform a large number of T-cell assays. We therefore needed to compensate for the lack of statistical data analysis methods for ELISPOT assays... - The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivoJason A Tye-Din
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Clin Immunol 134:289-95. 2010..Symptoms typically associated with gluten ingestion occurred in both groups and were not significantly reduced by ALV003 pre-treatment. ALV003 pre-treatment can abolish immune responses induced by gluten in patients with celiac disease... - Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac diseaseJason A Tye-Din
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
Sci Transl Med 2:41ra51. 2010..Our findings show that pathogenic T cells in celiac disease show limited diversity, and therefore suggest that peptide-based therapeutics for this disease and potentially other strongly HLA-restricted immune diseases should be possible... - Non-axial bone fracture but not depression as a risk factor for coeliac diseaseV P Tan
Department of Gastroenterology, Monash University, and Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia
Intern Med J 40:225-7. 2010..Patients presenting with non-axial fractures may be a subgroup in whom coeliac screening may be indicated. There needs to be greater awareness of atypical presentations of coeliac disease... - Systematic review: The evidence base for long-term management of coeliac diseaseM L Haines
Department of Gastroenterology, Monash University Department of Medicine, Box Hill Hospital, Box Hill, and Walter and Eliza Hall Institute, Parkville, Vic, Australia
Aliment Pharmacol Ther 28:1042-66. 2008..While gluten-free diet is an effective treatment for coeliac disease, the need for and goals of long-term management of patients are poorly defined... - Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cellsAndrea L de Kauwe
Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
J Immunol 182:7440-50. 2009.... - A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac diseaseKate N Henderson
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Immunity 27:23-34. 2007..Accordingly, nondietary therapeutic interventions in celiac disease might need to be tailored to the genotype of the individual... - The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac diseaseKate N Henderson
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:1021-5. 2007..Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 alpha-I (PQPELPYPQ) and DQ8 alpha-I (EGSFQPSQE), respectively, are reported...