Research Topics
| A G CumminsSummaryAffiliation: South Australia Country: Australia Publications
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Publications
Postnatal epithelial growth of the small intestine in the rat occurs by both crypt fission and crypt hyperplasiaAdrian G Cummins
Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia
Dig Dis Sci 51:718-23. 2006..No conventional growth factor was identified during crypt fission. We conclude that crypt fission contributes to growth of the small intestine prior to weaning and crypt hyperplasia to growth after weaning...- Crypt fission peaks early during infancy and crypt hyperplasia broadly peaks during infancy and childhood in the small intestine of humansAdrian G Cummins
Department of Gastroenterology and Hepatology, Digestive Disease Research Centre, Basil Hetzel Institute for Medical Research, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia
J Pediatr Gastroenterol Nutr 47:153-7. 2008..Postnatal growth of the small intestine occurs by crypt hyperplasia and by the less recognised mechanism of crypt fission. How the small intestine grows is largely extrapolated from animals and is poorly described in humans... - Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac diseaseA G Cummins
Department of Gastroenterology and Hepatology, DX 465384, The Queen Elizabeth Hospital, Woodville South, SA 5011, Australia
Clin Sci (Lond) 100:379-86. 2001..We conclude that intestinal permeability improves within 2 months after starting a GFD, but that measurable intestinal biopsy improvement requires ingestion of a GFD for at least 3-6 months, and even then remains incomplete... - Effect of breast milk and weaning on epithelial growth of the small intestine in humansA G Cummins
Bazil Hetzel Research Institute and the Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
Gut 51:748-54. 2002..Here, we offer a view that integrates some of these factors, especially those relating to breast feeding and weaning... - Morphometric evaluation of duodenal biopsies in celiac diseaseAdrian G Cummins
Digestive Disease Research Centre, Basil Hetzel Institute for Medical Research, Adelaide, South Australia, Australia
Am J Gastroenterol 106:145-50. 2011..We have explored the possibility that quantitative changes in villous area and crypt length (morphometry) may provide better information on changes in duodenal morphology, particularly after the introduction of a gluten-free diet... - Prevalence of celiac disease in the Asia-Pacific regionAdrian G Cummins
Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
J Gastroenterol Hepatol 24:1347-51. 2009..There is also the potential for a rising incidence of celiac disease if traditional rice-based diets are replaced by Western-style diets with a higher content of wheat products... - Cellular mucosal defense is attenuated with chronicity of Helicobacter pylori infectionGeoffrey M Matthews
Gastroenterology Department, Women s and Children s Hospital, North Adelaide, South Australia
Dig Dis Sci 49:1109-15. 2004..05). These results suggest an up-regulation of the antioxidant defense system during H. pylori infection in the mouse but not in humans. N-Acetylcysteine reduces the response during infection possibly by lowering the oxidant load... - Irinotecan causes severe small intestinal damage, as well as colonic damage, in the rat with implanted breast cancerRachel J Gibson
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
J Gastroenterol Hepatol 18:1095-100. 2003..The aim of the present study was to investigate the time-course of apoptosis and whole intestinal damage after irinotecan to further elucidate the mechanism behind the diarrhea... - The role of capsule endoscopy in suspected celiac disease patients with positive celiac serologyIlmars Lidums
Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Woodville South, SA, Australia
Dig Dis Sci 56:499-505. 2011..As villous atrophy may be patchy, duodenal biopsies could potentially miss the abnormalities. Capsule endoscopy can obtain images of the whole small intestine and may be useful in the early diagnosis of celiac disease... - Relationship between dose of methotrexate, apoptosis, p53/p21 expression and intestinal crypt proliferation in the ratR J Gibson
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
Clin Exp Med 4:188-95. 2005..We conclude that apoptosis is not always associated with crypt cell hypoproliferation and that the small intestine can recover after low dose MTX despite a heightened peak of apoptosis of crypt cells... - Effect of interleukin-11 on ameliorating intestinal damage after methotrexate treatment of breast cancer in ratsRachel J Gibson
Department of Medical Oncology, The Royal Adelaide Hospital, Adelaide, South Australia, Australia
Dig Dis Sci 47:2751-7. 2002..We conclude that IL-11 attenuated mucositis by maintaining intestinal weight and morphometry. IL-11 did not prevent apoptosis, but rather induced compensatory crypt cell proliferation... - Role of p53 in irinotecan-induced intestinal cell death and mucosal damageJoanne M Bowen
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
Anticancer Drugs 18:197-210. 2007..Temporary inhibition of p53 activation does not markedly prevent intestinal cell death or mucositis following irinotecan treatment. Irinotecan may act through upregulation of proapoptotic proteins Bax and Bak to induce cell death... - Irinotecan changes gene expression in the small intestine of the rat with breast cancerJoanne M Bowen
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, South Australia, Australia
Cancer Chemother Pharmacol 59:337-48. 2007..The aims of this study were to identify genes that are altered by irinotecan, to determine how these genes contribute to apoptosis and to identify any potential gene families and pathways that are important for mucositis development... - The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitisA J Wigg
Department of Gastroenterology, Queen Elizabeth Hospital, Adelaide, South Australia, Australia
Gut 48:206-11. 2001..Small intestinal bacterial overgrowth may contribute to the development of non-alcoholic steatohepatitis, perhaps by increasing intestinal permeability and promoting the absorption of endotoxin or other enteric bacterial products... - Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humansD M Keefe
Department of Gastroenterology, Queen Elizabeth Hospital, Woodville South, South Australia 5011, Australia
Gut 47:632-7. 2000..The mechanism of gastrointestinal damage (mucositis) induced by cancer chemotherapy remains uncertain. The aims of this study were to define the time course and mechanism of small intestinal damage following chemotherapy in humans... - Deficiency of invariant natural killer T cells in coeliac diseaseR H Grose
Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Woodville Road, Woodville South, 5011, South Australia, Australia
Gut 56:790-5. 2007..Immunoregulatory invariant natural killer (iNK) T cells rapidly produce interleukin (IL)-4 and other cytokines that suppress a Th1 response and are deficient in some autoimmune diseases... - Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant ratsKimberley S Camac
Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Woodville South, Australia
Dig Dis Sci 52:1242-6. 2007..Tcf-4 nuclear expression peaked earlier at 7 days and was lower thereafter with age. We conclude that the Wnt/beta-catenin pathway is activated in the stem cell region of intestinal crypts during growth of the small intestine... - Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damageJoanne M Bowen
Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, South Australia, Australia
Support Care Cancer 14:713-31. 2006..This review will provide an overview of current research as well as identify areas where gaps in knowledge exist... - The effect of keratinocyte growth factor on tumour growth and small intestinal mucositis after chemotherapy in the rat with breast cancerRachel J Gibson
Department of Gastroenterology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
Cancer Chemother Pharmacol 50:53-8. 2002..KGF also reduced tumour size. CONCLUSIONS: We conclude that KGF had a modest effect on intestinal growth prior to chemotherapy. It did not protect the gut from mucositis, nor did it worsen morphometry. It reduced tumour size... - Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milkB A Eglinton
Gastroenterology Unit, Queen Elizabeth Hospital, Woodville South, Adelaide, Australia
Immunol Cell Biol 72:306-13. 1994..Breast milk contained high levels of IFN-gamma but low levels of other measured cytokines compared to blood. These distinct differences of T cells and their soluble products are likely to influence an infant's immune system... - Deficiency of invariant NK T cells in Crohn's disease and ulcerative colitisRandall H Grose
Basil Hetzel Institute for Medical Research and Department of Medicine, University of Adelaide, Adelaide, Australia
Dig Dis Sci 52:1415-22. 2007..05). Intestinal Valpha24+ T cells were 23% in Crohn's disease but not reduced in ulcerative colitis. We conclude that invariant NK T cells are deficient in Crohn's disease and in ulcerative colitis... - CRP correlates with clinical score in ulcerative colitis but not in Crohn's diseaseAlexander D Rodgers
Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Woodville Road, Woodville South, South Australia 5011, Australia
Dig Dis Sci 52:2063-8. 2007.... - Deficiency of 6B11+ invariant NK T-cells in celiac diseaseRandall H Grose
Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, University of Adelaide, Woodville South, SA 5011, Australia
Dig Dis Sci 53:1846-51. 2008..V alpha 24/GAPDH mRNA from celiac subjects was reduced to 5% of levels in control subjects. We conclude that immunoregulatory NK T-cells are deficient in celiac disease... - Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humansJoanne M Bowen
Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia
Pathology 37:56-62. 2005..The aim of this study was to examine the effect of cytotoxic treatment on Bcl-2 protein expression in patients and rats with tumours... - 13C-urea breath test: reproducibility and association with the severity of Helicobacter pylori-associated antral gastritisGeoffrey M Matthews
Center for Paediatric and Adolescent Gastroenterology, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA 5006, Australia
J Gastroenterol Hepatol 20:270-4. 2005..55) and myeloperoxidase activity (r = 0.82) but not with bacterial load. conclusion: The (13)C-UBT is a reproducible determinant of H. pylori infection and non-invasively assesses the severity of antral inflammation... - Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteinsGuy R Sander
Tissue Development and Repair, Epithelial Biology Laboratory, Child Health Research Institute, 72 King William Road, North Adelaide, SA 5006, Australia
FEBS Lett 579:4851-5. 2005..Gliadin caused a reorganisation of actin filaments and altered expression of the tight junction proteins occludin, claudin-3 and claudin-4, the TJ-associated protein ZO-1 and the adherens junction protein E-cadherin...