Research Topics
Genomes and Genes
| Sarah E MedlandSummaryAffiliation: Queensland Institute of Medical Research Country: Australia Publications
| Collaborators
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Detail Information
Publications
Special twin environments, genetic influences and their effects on the handedness of twins and their siblingsSarah E Medland
Genetic Epidemiology Unit, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia
Twin Res 6:119-30. 2003....- An integrated phenomic approach to multivariate allelic associationSarah Elizabeth Medland
Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Eur J Hum Genet 18:233-9. 2010..Perl scripts that takes ped and dat files as input and produces Mx scripts and data for running the CMV approach can be downloaded from www.vipbg.vcu.edu/~sarahme/WriteMx... - Ridgecounter: a program for obtaining semi-automated finger ridge countsSarah E Medland
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
Ann Hum Biol 34:504-17. 2007..962) (the prints were obtained 2 years apart and counted by the same researcher). Although designed for use with fingerprints, the program is suitable for use with palm, foot or toe prints using user-defined landmarks... - Common variants in the trichohyalin gene are associated with straight hair in EuropeansSarah E Medland
Queensland Institute of Medical Research, Brisbane 4029, Australia
Am J Hum Genet 85:750-5. 2009..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations... - Multivariate genetic analyses of the 2D:4D ratio: examining the effects of hand and measurement technique in data from 757 twin familiesSarah E Medland
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Twin Res Hum Genet 11:335-41. 2008.... - Efficient calculation of empirical P-values for genome-wide linkage analysis through weighted permutationSarah E Medland
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Behav Genet 39:91-100. 2009..We demonstrate the validity of this approach through simulation... - Genetic influences on handedness: data from 25,732 Australian and Dutch twin familiesSarah E Medland
Queensland Institute of Medical Research, Australia
Neuropsychologia 47:330-7. 2009..17, 27.09%) with the remainder accounted for by non-shared environmental influences. The implications of these findings for handedness both as a primary phenotype and as a covariate in linkage and association analyses are discussed... - Males do not reduce the fitness of their female co-twins in contemporary samplesSarah E Medland
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Australia
Twin Res Hum Genet 11:481-7. 2008..Similarly, there were no differences in psychological femininity between women from pairs of the same or opposite sex... - A note on the parameterization of Purcell's G x E model for ordinal and binary dataSarah E Medland
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Behav Genet 39:220-9. 2009..However, the scale of the results is dependent on the specification of (threshold or variance) constraints rather than the underlying distribution of liability. Example Mx scripts are provided... - Modeling extended twin family data II: power associated with different family structuresSarah E Medland
Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, United States of America
Twin Res Hum Genet 12:19-25. 2009..These results demonstrate that the Cascade model has sufficient power to detect parameters of interest in existing datasets. Mx scripts are available from www.vipbg.vcu.edu/~sarahme/cascade... - Handedness in twins: joint analysis of data from 35 samplesSarah E Medland
Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 9:46-53. 2006..This lack of power is seldom mentioned within studies, and has contributed to the misconception that twin studies of handedness are not informative... - Alternate parameterization for scalar and non-scalar sex-limitation models in MxSarah E Medland
Queensland Institute of Medical Research, Brisbane QLD, Australia
Twin Res 7:299-305. 2004..2002). These models are designed for use with extended pedigrees and take advantage of the dynamic treatment of covariates within Mx. Example scripts are provided... - Opposite effects of androgen receptor CAG repeat length on increased risk of left-handedness in males and femalesSarah E Medland
Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane 4029, Australia
Behav Genet 35:735-44. 2005..Thus, consistent with Witelson's theory of testosterone action, in all three samples the likelihood of left handedness increased in those individuals with variants of the androgen receptor associated with lower testosterone levels... - Sequence variants in three loci influence monocyte counts and erythrocyte volumeManuel A R Ferreira
Queensland Institute of Medical Research QIMR, Brisbane, QLD 4029, Australia
Am J Hum Genet 85:745-9. 2009..001, 9.9x10(-5), and 7x10(-5), respectively). The identification of these QTL provides new opportunities for furthering our understanding of the mechanisms regulating hemopoietic cell fate... - Flexible Mx specification of various extended twin kinship designsHermine H Maes
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, United States of America
Twin Res Hum Genet 12:26-34. 2009..Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest... - Linkage analysis of a model quantitative trait in humans: finger ridge count shows significant multivariate linkage to 5q14.1Sarah E Medland
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
PLoS Genet 3:1736-44. 2007.... - Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblingsPeter M Visscher
Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane, Australia
PLoS Genet 2:e41. 2006.... - Genome-wide association study of height and body mass index in Australian twin familiesJimmy Z Liu
Queensland Statistical Genetics, Genetic Epidemiology and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Australia
Twin Res Hum Genet 13:179-93. 2010..Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI... - A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personalityKarin J H Verweij
Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Biol Psychol 85:306-17. 2010.... - Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in AustraliaManuel A R Ferreira
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Eur J Hum Genet 19:458-64. 2011..In conclusion, we confirm the association between asthma risk and variants in ORMDL3 and identify a novel risk variant in IL1RL1. Follow-up of the 17q21 deletion in larger cohorts is warranted... - Genetic covariation between theAuthor Recognition Test and reading and verbal abilities: what can we learn from the analysis of high performance?Nicolas W Martin
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, QLD, Australia
Behav Genet 39:417-26. 2009..This suggests a distinct genetic etiology for high ART ability and we speculate that the specific genetic influence is on orthographical processing, a critical factor in developing word recognition skills... - A versatile gene-based test for genome-wide association studiesJimmy Z Liu
Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
Am J Hum Genet 87:139-45. 2010..We have implemented the approach in both an easy-to-use web interface, which only requires the uploading of markers with their association p-values, and a separate downloadable application... - Educational attainment: a genome wide association study in 9538 AustraliansNicolas W Martin
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
PLoS ONE 6:e20128. 2011..8. This makes EA an attractive alternative phenotype for studies wishing to map genes affecting cognition due to the ease of collecting EA data compared to other cognitive phenotypes such as IQ... - Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studiesKarin J H Verweij
Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD, Australia
Addiction 105:417-30. 2010.... - A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposureSarah E Medland
Genetic Epidemiology, Queensland Institute of Medical Research, Australia
Am J Hum Genet 86:519-25. 2010..Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure... - Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associationsRita P Middelberg
Queensland Institute of Medical Research, Brisbane, Australia
Hum Mol Genet 21:446-55. 2012..Our results reinforce the disease associations of GGT and demonstrate that control by the GGT1 locus varies with age... - Genetic and environmental influences on the co-morbidity between depression, panic disorder, agoraphobia, and social phobia: a twin studyMiriam A Mosing
Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
Depress Anxiety 26:1004-11. 2009..However, the relative importance of genetic and environmental etiology of the covariation between these disorders, particularly the relationship between PD and AG, is less clear... - GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern developmentMats Larsson
Queensland Institute of Medical Research, Brisbane, Australia
Am J Hum Genet 89:334-43. 2011..These findings suggest that genes involved in normal neuronal pattern development may also influence tissue structures in the human iris... - Sex-limited genome-wide linkage scan for body mass index in an unselected sample of 933 Australian twin familiesBelinda K Cornes
Genetic Epidemiology, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD, Australia
Twin Res Hum Genet 8:616-32. 2005.... - A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin familiesKatherine I Morley
Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
Behav Genet 36:87-99. 2006..We identified one region suggestive of linkage on chromosome 11p12. This locus, as well as another region identified on chromosome 6p12, replicates regions identified in previous studies... - No association of candidate genes with cannabis use in a large sample of Australian twin familiesKarin J H Verweij
Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia School of Psychology, University of Queensland, Brisbane, Queensland, Australia Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
Addict Biol 17:687-90. 2012..05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies... - Estimating the heritability of hair curliness in twins of European ancestrySarah E Medland
Queensland Institute of Medical Research, PO Royal Brishbane Hopsital, Brisbane, Australia
Twin Res Hum Genet 12:514-8. 2009..Given the magnitude and the specificity of the EDAR effect on hair morphology in Asian populations we are hopeful that future association studies will detect similar genetic influences in European populations... - A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: psychoticism, extraversion, neuroticism, and lieNathan A Gillespie
Queensland Institute of Medical Research, Brisbane, Australia
J Pers 76:1415-46. 2008..The highest linkage peaks were found on chromosomes 16 and 19 for Neuroticism, on chromosomes 1, 7, 10, 13 m, and 18 for Psychoticism, and on chromosomes 2 and 3 for Extraversion... - LPAR1 and ITGA4 regulate peripheral blood monocyte countsNarelle Maugeri
Queensland Institute of Medical Research, Brisbane, Australia
Hum Mutat 32:873-6. 2011..Further studies that investigate the downstream mechanism involved and the impact on immune function are warranted... - Genomewide significant linkage to migrainous headache on chromosome 5q21Dale R Nyholt
Queensland Institute of Medical Research, Brisbane, Australia
Am J Hum Genet 77:500-12. 2005..These results will prove to be invaluable in the design and analysis of future linkage and linkage disequilibrium studies of migraine... - A genome-wide association study of self-rated healthMiriam A Mosing
Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Twin Res Hum Genet 13:398-403. 2010..A very large sample will be needed to identify these SNPs... - Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune controlManuel A R Ferreira
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Am J Hum Genet 86:88-92. 2010.... - Genetic influences on life span and its relationship to personality: a 16-year follow-up study of a sample of aging twinsMiriam A Mosing
GeneticEpidemiology Unit, Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, Queensland 4006, Australia
Psychosom Med 74:16-22. 2012..The present study aimed to explore the phenotypic and genetic relationship between personality and life span, as well as genetic influences on all-cause mortality... - The genetics of voting: an Australian twin studyPeter K Hatemi
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, QLD, Australia
Behav Genet 37:435-48. 2007.... - Variation in BMPR1B, TGFRB1 and BMPR2 and control of dizygotic twinningHien T T Luong
Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 14:408-16. 2011..Our results suggest that variation in the TGF9 signaling pathway type II receptors has limited effects on DZ twinning rates in humans... - GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factorsBeben Benyamin
Queensland Institute of Medical Research, Brisbane 4006, Australia
Hum Mol Genet 20:4504-14. 2011..We conclude that variation in BCHE activity is due to multiple variants across the spectrum from uncommon/large effect to common/small effect, and partly results from (rather than causes) metabolic abnormalities... - Genome-wide association identifies ATOH7 as a major gene determining human optic disc sizeStuart Macgregor
Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Australia
Hum Mol Genet 19:2716-24. 2010..0136). Furthermore, the Arg65Gly variant was found to have very low frequency (0.00066) in an additional set of 672 controls... - A longitudinal genetic study of uric acid and liver enzymes in adolescent twinsRita P S Middelberg
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 10:757-64. 2007..The nonshared environment effects were generally time specific. There are developmental changes in genes affecting these traits during adolescence... - Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traitsJian Yang
1 Queensland Institute of Medical Research, Brisbane, Queensland, Australia 2 University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Nat Genet 44:369-75. 2012..The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium... - A genome scan for eye color in 502 twin families: most variation is due to a QTL on chromosome 15qGu Zhu
Queensland Institute of Medical Research, Brisbane, Australia
Twin Res 7:197-210. 2004..We conclude that most variation in eye color in Europeans is due to polymorphism in OCA2 but that there may be modifiers at several other loci... - ViewPoint and ViewDist: utilities for rapid graphing of linkage distributions and identification of outliersHarry N Beeby
Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia
Behav Genet 36:7-11. 2006.... - Estimating heritability from twin studiesKarin J H Verweij
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, QLD, Australia
Methods Mol Biol 850:151-70. 2012..OpenMx and the scripts used for this chapter can be downloaded so that readers can adapt and use the scripts for their own purposes... - Parameterization of sex-limited autosomal linkage analysis for MxSarah E Medland
Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Australia
Twin Res Hum Genet 8:569-73. 2005..2002). An example script designed for use with extended sibships that takes advantage of the versatile treatment of covariates within Mx is included... - Gender diagnosticity and androgen receptor gene CAG repeat sequenceJohn C Loehlin
Department of Psychology, University of Texas, Austin, TX 78712 0187, USA
Twin Res 7:456-61. 2004..Clarification of these relationships will require large samples and measurements at additional ages... - Population differences in finger-length ratios: ethnicity or latitude?John C Loehlin
Department of Psychology, University of Texas, Austin, Texas 78712 0187, USA
Arch Sex Behav 35:739-42. 2006..S. studies. The Australian 2D:4D ratios resembled those in Britain rather than those in the U.S., tending to exclude hypotheses related to latitude and making differences in gene pools a plausible explanation...