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Species | Scott R BurrowsSummaryAffiliation: Queensland Institute of Medical Research Country: Australia Publications
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Publications
Have we cut ourselves too short in mapping CTL epitopes?Scott R Burrows
Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4029, Australia
Trends Immunol 27:11-6. 2006..We propose that algorithms widely used to predict class I-binding peptides should now be broadened to include peptides of over ten residues in length...- Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytesMichael P Pender
The University of Queensland, School of Medicine, Health Sciences Building, Royal Brisbane and Women s Hospital, Queensland 4029, Australia
BMC Neurol 11:95. 2011.... - The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMVJacqueline M Burrows
Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Australia
Eur J Immunol 37:946-53. 2007..Such influences may provide the evolutionary pressure that maintains closely related MHC molecules in diverse human populations... - Understanding human T-cell-mediated immunoregulation through herpesvirusesScott R Burrows
Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Immunol Cell Biol 89:352-8. 2011..It is highly likely that these newly emerging T-cell-based therapeutic and diagnostic technologies will revolutionize the clinical management of patients with herpesvirus-associated diseases... - TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitopeJohn J Miles
Cellular Immunology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
J Immunol 177:6804-14. 2006..In addition, TCR alpha-chain usage is shown to play a critical role in controlling MHC restriction between closely related allomorphs... - Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infectionKatherine K Wynn
Australian Centre for Vaccine Development and Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Australia
Blood 111:4283-92. 2008..These findings provide new insights into our understanding on how the biology of antigen presentation in addition to the structural features of the pMHC-I might shape the T-cell repertoire and its phenotype... - CTL recognition of a bulged viral peptide involves biased TCR selectionJohn J Miles
Cellular Immunology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
J Immunol 175:3826-34. 2005..The data show that bulged viral peptides are indeed immunogenic but suggest that the highly constrained TCR repertoire reflects a limit to TCR diversity when responding to some unusual MHC peptide ligands... - The peptide length specificity of some HLA class I alleles is very broad and includes peptides of up to 25 amino acids in lengthMelissa J Bell
Queensland Institute of Medical Research and Australian Centre for Vaccine Development, Herston, Brisbane, Australia
Mol Immunol 46:1911-7. 2009..Furthermore, the findings provide an explanation for recent reports highlighting that epitopes of >10 amino acids play a minor but significant role in virus-specific immune surveillance by CD8(+) T cells... - Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell responseMelissa J Bell
Queensland Institute of Medical Research and Australian Centre for Vaccine Development, University of Queensland, Brisbane, Australia
J Infect Dis 197:1594-7. 2008..Importantly, T cell recognition of an endogenously processed HLA-B8 - binding EBNA1 epitope was greatly influenced by this sequence polymorphism... - Promiscuous CTL recognition of viral epitopes on multiple human leukocyte antigens: biological validation of the proposed HLA A24 supertypeScott R Burrows
Department of Molecular and Cellular Pathology, University of Queensland, Brisbane, Australia
J Immunol 171:1407-12. 2003..The degeneracy in HLA restriction displayed by some T cells in this study also suggests that the dogma of self-MHC restriction needs some refinement to accommodate foreign peptide recognition in the context of multiple supertype alleles... - Predictable alphabeta T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitopeRebekah M Brennan
Queensland Institute of Medical Research, 300 Herston Road, Brisbane 4029, Australia
J Virol 81:7269-73. 2007..The ability to predict the responding alphabeta TcR repertoire before viral infection should prove a powerful tool for basic and clinical immunology... - Potent T cell response to a class I-binding 13-mer viral epitope and the influence of HLA micropolymorphism in controlling epitope lengthKate J Green
Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Australia
Eur J Immunol 34:2510-9. 2004..Furthermore, the potency of the response indicates that peptides of this length do not present a major structural barrier to CTL recognition... - Preferential binding of unusually long peptides to MHC class I and its influence on the selection of target peptides for T cell recognitionJacqueline M Burrows
Queensland Institute of Medical Research and Australian Centre for Vaccine Development, 300 Herston Road, Herston 4029, Brisbane, Australia
Mol Immunol 45:1818-24. 2008..These data suggest that the peptide length specificity of some HLA class I alleles is broad, allowing peptides of >10 residues to sometimes dominate over canonical length class I ligands as targets for T cell recognition... - Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-/nonself-recognitionMichael Rist
Australian Centre for Vaccine Development and Tumour Immunology Laboratory, Division of Infectious Immunology, Queensland Institute of Medical Research, Brisbane, Australia
Blood 114:2244-53. 2009..These results illustrate a novel mechanism whereby virus-specific CD8(+) T cells can cross-recognize HLA class II molecules and may contribute toward allograft rejection and/or autoimmunity... - Expansion of EBNA1-specific effector T cells in posttransplantation lymphoproliferative disordersKimberley Jones
Clinical Immunohaematology Laboratory and Australian Centre for Vaccine Development, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4006, Australia
Blood 116:2245-52. 2010..These results indicate that EBNA1-specific T cells should be included in adoptive immunotherapy for PTLD. Furthermore, expansion protocols should use antigenic sequences from relevant EBV strains... - Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from Southeast AsiaJacqueline M Burrows
Tumour Immunology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, and Department of Molecular and Cellular Pathology, University of Queensland, Brisbane, Australia 4029
J Virol 78:7131-7. 2004.... - The impact of a large and frequent deletion in the human TCR ? locus on antiviral immunityRebekah M Brennan
Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
J Immunol 188:2742-8. 2012..Thus, variation in the size of the TRBV repertoire clearly contributes toward interindividual variability in immune responses and is presumably maintained in many ethnic groups to enhance the diversity of Ag-specific T cell responses... - Endogenous presentation of CD8+ T cell epitopes from Epstein-Barr virus-encoded nuclear antigen 1Judy Tellam
EBV Unit, Tumour Immunology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, 300 Herston Road, Brisbane (Qld) 4006, Australia
J Exp Med 199:1421-31. 2004..Based on these observations, we propose that defective ribosomal products, not the full-length antigen, are the primary source of endogenously processed CD8+ T cell epitopes from EBNA1... - An HLA-A2-restricted T-cell epitope mapped to the BNLF2a immune evasion protein of Epstein-Barr virus that inhibits TAPMelissa J Bell
Queensland Institute of Medical Research, 300 Herston Rd, Brisbane 4029, Australia
J Virol 83:2783-8. 2009..The mechanism for this unexpected finding was revealed by experiments showing that this epitope is processed and presented independently of TAP... - Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosisSuzanne L Elliott
Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Queensland 4029, Australia
J Virol 82:1448-57. 2008..Single-epitope vaccination did not predispose individuals to disease, nor did it significantly influence development of a normal repertoire of EBV-specific CD8(+) T-cell responses following seroconversion... - Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infectionJohn J Miles
Queensland Institute of Medical Research, Queensland 4029, Australia
J Immunol 186:901-12. 2011..Notably, many of the anti-HCV TCRs switched TRBV and TRBJ genes around a conserved, N nucleotide-encoded CDR3 core, revealing TCR sequence mosaicism as a potential host mechanism to combat this highly variant virus... - Engineered T cell receptors and their potential in molecular medicineJohn J Miles
Cellular Immunology Laboratory, Queensland Institute of Medical Research, Herston 4029, Queensland, Australia
Curr Med Chem 13:2725-36. 2006..This review will discuss these studies and other approaches through which T cell receptors can be exploited in immunodiagnostics, pathogen control and gene therapy... - Cross-reactive recognition of viral and self-peptides by a "public" T cell receptor expressed by cytotoxic T lymphocytes expanded in multiple unrelated individualsScott R Burrows
Queensland Institute of Medical Research, 300 Herston Road, Brisbane 4029, Australia
Immunol Lett 93:7-9. 2004 - Ex vivo analysis of T-cell responses to Epstein-Barr virus-encoded oncogene latent membrane protein 1 reveals highly conserved epitope sequences in virus isolates from diverse geographic regionsJaikumar Duraiswamy
Cooperative Research Centre for Vaccine Technology, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Department of Molecular and Cellular Pathology, University of Queensland, Brisbane, Australia 4029
J Virol 77:7401-10. 2003..These findings indicate that conserved LMP1 epitopes should be considered in designing epitope-based immunotherapeutic strategies against EBV-associated malignancies in different ethnic populations... - T cell allorecognition and MHC restriction--A case of Jekyll and Hyde?Julia K Archbold
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Mol Immunol 45:583-98. 2008..This review highlights some of the important findings from studies characterizing the way in which alloreactive T cell receptors and pMHC molecules interact in an attempt to resolve this great irony of the cellular immune response... - Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejectionLauren K Ely
Department of Biochemistry and Molecular Biology, Protein Crystallography Unit, School of Biomedical Sciences, Monash University, Clayton, Australia
J Immunol 174:5593-601. 2005.... - T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptideFleur E Tynan
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Nat Immunol 6:1114-22. 2005..Thus our findings simultaneously demonstrate the considerable adaptability of the TCR and the 'shape' of MHC restriction... - The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformationFleur E Tynan
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
J Exp Med 202:1249-60. 2005..It also illustrates a novel mechanism through which MHC polymorphism can further diversify the immune response to infecting pathogens... - T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 yearsJohn J Miles
Blood 106:4412-3. 2005 - Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicryJulia K Archbold
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
J Biol Chem 281:34324-32. 2006..This cross-reactivity underpins the T cell degeneracy inherent in the limited mature T cell repertoire that must respond to a vast diversity of microbial antigens... - A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunityLars Kjer-Nielsen
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Immunity 18:53-64. 2003..These findings indicate that TCR immunodominance is associated with structural properties conferring receptor specificity and suggest a novel structural link between TCR ligation and intracellular signaling... - A mechanism for the HLA-A*01-associated risk for EBV+ Hodgkin lymphoma and infectious mononucleosisRebekah M Brennan
Blood 112:2589-90. 2008 - T-cell allorecognition: a case of mistaken identity or déjà vu?Julia K Archbold
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
Trends Immunol 29:220-6. 2008.... - High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominanceFleur E Tynan
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
J Biol Chem 280:23900-9. 2005..Biased TcR usage in this cytotoxic T lymphocyte response appears to reflect a dominant role of the prominent peptide x major histocompatibility complex class I surface... - T-cell receptor bias and immunityStephanie Gras
The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Curr Opin Immunol 20:119-25. 2008..Here we review recent advances in the field, focussing on structural data pertaining to biased TCR usage, and discuss the implications for T-cell repertoire selection, MHC restriction and therapeutic development... - The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognitionNatalie A Borg
The Protein Crystallography Unit, Monash Centre for Synchrotron Science, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Nat Immunol 6:171-80. 2005..Therefore the energetic burden of the CDR loops in the TCR-pMHC interaction is variable among TCRs, reflecting the inherent adaptability of the TCR in ligating different ligands... - A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognitionWhitney A Macdonald
Dept. of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
J Exp Med 198:679-91. 2003..The findings suggest that these closely related class I genes are maintained in diverse human populations through their differential impact on the selection of peptide ligands and the T cell repertoire... - A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I moleculeFleur E Tynan
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Nat Immunol 8:268-76. 2007..Our findings represent a mechanism of antigen recognition whereby the plasticity of the T cell response is dictated mainly by adjustments in the MHC-bound peptide...