Research Topics
Species | Steven A StackerSummaryAffiliation: Peter MacCallum Cancer Centre Country: Australia Publications
| Collaborators
|
Detail Information
Publications
Targeting lymphatic vessel functions through tyrosine kinasesSteven P Williams
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
J Angiogenes Res 2:13. 2010..This review will discuss the role of tyrosine kinases in lymphatic biology and the potential use of inhibitors for anti-lymphangiogenic therapy...
Molecular control of lymphatic metastasisMarc G Achen
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
Ann N Y Acad Sci 1131:225-34. 2008..This article provides an overview of the molecular mechanisms that control lymphatic metastasis and discusses potential therapeutic approaches for inhibiting this process in human cancer...
From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in cancer therapySteven A Stacker
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
Lymphat Res Biol 6:165-72. 2008..History may show that anti-angiogenesis provided the vantage point from which anti-lymphangiogenesis was seen as a viable concept for targeting tumors and other pathological conditions...
Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancerNicole C Harris
Ludwig Institute for Cancer Research, Department of Surgery, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
FASEB J 25:2615-25. 2011..Our results indicate that proteolytic processing is necessary for VEGF-D to promote the growth and spread of cancer, and suggest that enzymes catalyzing this processing could be targets for antimetastatic therapeutics...
A role for bone morphogenetic protein-4 in lymph node vascular remodeling and primary tumor growthRae H Farnsworth
Ludwig Institute for Cancer Research, University of Melbourne, Parkville, Australia
Cancer Res 71:6547-57. 2011..Furthermore, they implicate BMP-4 as a negative regulator of this process, suggesting its potential utility as a prognostic marker or antitumor agent...
A system for quantifying the patterning of the lymphatic vasculatureRamin Shayan
Melbourne Tumor Biology Branch, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
Growth Factors 25:417-25. 2007..This efficient, reproducible technique is validated by analysing healthy and pathological tissues...
Importance of Wnt signaling in the tumor stroma microenvironmentMaria L Macheda
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Curr Cancer Drug Targets 8:454-65. 2008..Future therapeutic targets for interfering with Wnt signaling include cell surface receptors such as the RYK and Ror2 receptors and secreted signaling molecules, which mediate signaling between cancer cells and the stromal environment...
The VD1 neutralizing antibody to vascular endothelial growth factor-D: binding epitope and relationship to receptor bindingNatalia Davydova
Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
J Mol Biol 407:581-93. 2011....
