Research Topics
| Sharon ChenSummaryAffiliation: New South Wales Country: Australia Publications
| Collaborators
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Detail Information
Publications
Active surveillance for candidemia, AustraliaSharon Chen
Westmead Hospital, Westmead, New South Wales, Australia
Emerg Infect Dis 12:1508-16. 2006..Adult critical care stay, sepsis syndrome, and corticosteroid therapy were associated with the greatest risk for death. Systematic epidemiologic studies that use standardized definitions for IHCA, OHCA, and CA candidemia are indicated...- Current status and future perspectives on molecular and serological methods in diagnostic mycologyAnna Lau
Centre for Infectious Diseases and Microbiology, University of Sydney, Australia
Future Microbiol 4:1185-222. 2009..Both the galactomannan and the serum beta-D-glucan test have value for diagnosing infection and monitoring therapeutic response... - Purification and characterization of secretory phospholipase B, lysophospholipase and lysophospholipase/transacylase from a virulent strain of the pathogenic fungus Cryptococcus neoformansS C Chen
Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
Biochem J 347:431-9. 2000..This is the first complete description of the purification and properties of a phospholipase, which may be involved in virulence, from a pathogenic fungus... - Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study GroupS Chen
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
Clin Infect Dis 31:499-508. 2000..Resistance to antifungal drugs was uncommon. The epidemiology of CNVN infection has changed substantially. Clinical manifestations of disease are influenced more strongly by host immune status than by cryptococcal variety... - A review of nucleic acid-based diagnostic tests for systemic mycoses with an emphasis on polymerase chain reaction-based assaysSharon C A Chen
Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, New South Wales, Australia
Med Mycol 40:333-57. 2002..The wide application of PCR-based assays relies on the introduction of standardized protocols following their evaluation in multicentre, prospective studies... - Antifungal agentsSharon C A Chen
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, NSW, Australia
Med J Aust 187:404-9. 2007..Caspofungin has minimal adverse effects. Combination antifungal therapy may be appropriate in selected patients with invasive fungal infections, but is empiric and driven by individual physician practice... - Reverse line blot hybridization assay for identification of medically important fungi from culture and clinical specimensXianyu Zeng
Centre for Infectious Diseases and Microbiology Public Health CIDM PH, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Australia
J Clin Microbiol 45:2872-80. 2007..Prior to incorporation of probes to detect other fungal species, ITS sequencing may be performed to achieve species identification... - Multiplex tandem PCR: a novel platform for rapid detection and identification of fungal pathogens from blood culture specimensAnna Lau
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
J Clin Microbiol 46:3021-7. 2008..The MT-PCR assay was able to provide rapid (<2 h), sensitive, and specific simultaneous detection and identification of fungal pathogens directly from blood culture specimens... - In vitro susceptibility of the yeast pathogen cryptococcus to fluconazole and other azoles varies with molecular genotypeHin Siong Chong
School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
J Clin Microbiol 48:4115-20. 2010..These results indicate that cryptococcal species, molecular genotype, and region of origin may be important when deciding treatment options for cryptococcosis... - Rapid identification and differentiation of Trichophyton species, based on sequence polymorphisms of the ribosomal internal transcribed spacer regions, by rolling-circle amplificationFanrong Kong
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Darcy Road, Westmead, New South Wales 2145, Australia
J Clin Microbiol 46:1192-9. 2008..Despite limited genetic variation between Trichophyton spp., the sensitive, specific RCA-based SNP detection assay showed potential as a simple, reproducible method for the rapid (2-h) identification of Trichophyton spp... - Development and clinical application of a panfungal PCR assay to detect and identify fungal DNA in tissue specimensAnna Lau
Faculty of Medicine, Centre for Infectious Diseases and Microbiology, Westmead Millennium Institute, University of Sidney, Australia
J Clin Microbiol 45:380-5. 2007..The results support the use of the panfungal PCR assay in combination with conventional laboratory tests for accurate identification of fungi in tissue specimens... - Role of prospective screening of blood for invasive aspergillosis by polymerase chain reaction in febrile neutropenic recipients of haematopoietic stem cell transplants and patients with acute leukaemiaCatriona Halliday
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia
Br J Haematol 132:478-86. 2006..Patients with consecutive positive results or intermittent-positive results (within 14 d) warrant immediate investigations for IA and the initiation of antifungal therapy... - Early use of posaconazole in the successful treatment of rhino-orbital mucormycosis caused by Rhizopus oryzaeJen Kok
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, Sydney, New South Wales, Australia
J Infect 55:e33-6. 2007..Posaconazole was well-tolerated. Our experience indicates that this new extended-spectrum azole antifungal agent can be used early in the course of zygomycete infection with good results... - Candidemia in nonneutropenic critically ill patients: risk factors for non-albicans Candida sppE Geoffrey Playford
Princess Alexandra Hospital, Queensland, Australia
Crit Care Med 36:2034-9. 2008..and with potentially fluconazole-resistant Candida spp. (C. glabrata and C. krusei) among candidemic intensive care unit patients...