Research Topics
Genomes and GenesSpecies | M ErnstSummaryAffiliation: Ludwig Institute for Cancer Research Country: Australia Publications
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Publications
Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalphaHiu Kiu
Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
Growth Factors 25:319-28. 2007..Finally, we have identified an additional, novel mechanism of crosstalk inhibition: a reduction in total cellular levels of gp130 following stimulation with LPS and TNFalpha...- Acquiring signalling specificity from the cytokine receptor gp130Matthias Ernst
Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
Trends Genet 20:23-32. 2004..The second mechanism is based on the capacity of certain cell types to integrate the often-conflicting information transduced by these two pathways, and to prevent pathological responses... - STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant miceMatthias Ernst
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia
J Clin Invest 118:1727-38. 2008..Collectively, our data have identified IL-11 as a crucial cytokine promoting chronic gastric inflammation and associated tumorigenesis mediated by excessive activation of STAT3 and STAT1... - Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?Andrew Jarnicki
Ludwig Institute for Cancer Research, PO Box 2008 Royal Melbourne Hospital, VIC 3050, Australia
Cell Div 5:14. 2010..These insights provide clues to the judicious interference of the gp130/Stat3 signaling cascade in therapeutically targeting cancer... - Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune responseMatthias Ernst
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
J Exp Med 196:589-604. 2002..Thus, our observations collectively suggest an enhanced innate immune response in Hck(F/F) mice thereby skewing innate immunity from a reversible physiological host defense response to one causing irreversible tissue damage... - Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantationM Ernst
Ludwig Institute for Cancer Research, PO Royal Melbourne Hospital, VIC 3050, Australia
J Exp Med 194:189-203. 2001..Therefore, the joint pathology in gp130(DeltaSTAT) mice is likely to arise from the disturbance of the otherwise balanced activation of the SHP-2/ras/Erk and STAT signaling cascades emanating from gp130... - The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation. Involvement of STAT3M Ernst
Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, P O Royal Melbourne Hospital, Victoria, 3050, Australia
J Biol Chem 274:9729-37. 1999..Thus, distinct cytoplasmic domains within the LIFRalpha, gp130, and GCSF-R transduce proliferative and differentiation suppressing signals... - Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant miceNiall C Tebbutt
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
Nat Med 8:1089-97. 2002..We propose a model whereby mucosal wound healing depends solely on activation of STAT1/3, whereas gastric hyperplasia ensues when the coordinated activation of the STAT1/3 and SHP2-Ras-ERK pathways is disrupted... - Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesisBrendan J Jenkins
Ludwig Institute for Cancer Research, Victoria, Australia
Blood 109:2380-8. 2007..Collectively, these data genetically define distinct roles of IL-6 and IL-11 in driving pathologic hematopoietic and lymphoid responses mediated by STAT3 hyperactivation... - Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathwaysM Ernst
Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, P O Royal Melbourne Hospital, Victoria 3050, Australia
J Biol Chem 271:30136-43. 1996.... - Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27Christine Brender
Signal Transduction Laboratory, St Vincent s Institute, Fitzroy, Victoria, Australia
Blood 110:2528-36. 2007..We conclude that enhanced responses to TCR ligation by SOCS3-deficient CD8 T cells are not caused by aberrant TCR-signaling pathways but, rather, that increased IL-27 signaling drives unregulated proliferation in the absence of SOCS3... - LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survivalHelmut Butzkueven
The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, Australia
Nat Med 8:613-9. 2002..We also demonstrate that this therapeutic effect complements endogenous LIF receptor signaling, which already serves to limit oligodendrocyte loss during immune attack. Our results provide a novel approach for the treatment of MS... - Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130Louise M Judd
Department of Medicine, University of Melbourne, Melbourne, Australia
Gastroenterology 126:196-207. 2004..We have developed a mouse model of gastric cancer that resembles human intestinal-type adenocarcinoma. The aim of this study was to determine the identity and temporal changes in mediators of IL-6 signaling regulating tumor development... - The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesisBrendan J Jenkins
Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
Blood 105:3512-20. 2005.... - IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient miceFrancesca Walker
Ludwig Institute for Cancer Research, Melbourne Tumor Biology Branch, Melbourne, Victoria, Australia
Blood 111:3978-85. 2008..NPA production by mice defective for both G-CSF and GM-CSF uncovers an alternative pathway to granulocyte production, which is activated after exposure to pathogens... - Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expressionBrendan J Jenkins
Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, Parkville, Victoria, Australia
Mol Cell Biol 24:1453-63. 2004.... - Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signalingBrendan J Jenkins
Ludwig Institute for Cancer Research, Molecular Biology Laboratory, Victoria, Australia
Exp Hematol 30:1248-56. 2002..This study examined the specific contribution of gp130-mediated STAT1/3 signaling to the regulation of hematopoiesis... - TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient miceNicole Flentjar
Centre for Functional Genomics and Human Disease, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
Gastroenterology 132:1410-9. 2007..To prove that the defect observed in Elf3-null mice resulted from the lack of Elf3-dependent activation of Tgf-betaRII expression, we performed a genetic rescue... - SOCS3 negatively regulates LIF signaling in neural precursor cellsB Emery
Multiple Sclerosis Group, The Howard Florey Institute, University of Melbourne, Melbourne, Victoria 3010, Australia
Mol Cell Neurosci 31:739-47. 2006..However, the clonal potential of SOCS3WT/WT but not SOCS3KO/KO NPCs is enhanced by exogenous LIF. Thus, SOCS3 acts as a negative regulator of LIF signaling in NPCs... - Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signalingBrendan J Jenkins
Ludwig Institute for Cancer Research, Parkville, VIC 3050, Australia
Nat Med 11:845-52. 2005.... - Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signalingD Ciznadija
Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Cell Death Differ 16:1530-8. 2009..These data highlight a cooperative function for MYB in the context of activated Wnt signaling and provide a molecular basis for the expression of MYC in CRC... - Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathwaysNatalie A Sims
Department of Medicine at St Vincent s Hospital, The University of Melbourne, Fitzroy, Victoria, Australia
J Clin Invest 113:379-89. 2004..Furthermore, the latter pathway can directly inhibit osteoclastogenesis in vivo... - Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesityGregory R Steinberg
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Australia
Diabetes 58:829-39. 2009..CNTF also increases Akt signaling in neurons and adipocytes. Because both Akt and AMPK regulate glucose uptake, we investigated muscle glucose uptake in response to CNTF signaling in lean and obese mice... - Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signalingMichael S Samuel
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
Gastroenterology 137:902-13, 913.e1-11. 2009..Here we use knock-in transgenic mice to investigate the consequences of intestinal epithelium-specific overexpression of de novo Dnmt3a... - Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expressionCameron N Johnstone
Ludwig Institute for Cancer Research, Melbourne Branch, Post Office Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
J Biol Chem 277:34531-9. 2002..Taken together, our data lead us to propose that the activity of CDX1 is pivotal in mediating the exquisite, intestine-specific expression pattern of the A33 antigen gene... - Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivoMichael Buchert
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
PLoS Genet 6:e1000816. 2010..Together, the present genotype-phenotype analysis suggests tissue-specific response levels for the Wnt/beta-catenin pathway that regulate both physiological and pathophysiological conditions... - The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnoverPeter K K Wong
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Arthritis Rheum 48:1177-89. 2003 - More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancerTracy Putoczki
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
J Leukoc Biol 88:1109-17. 2010.... - Identification of putative targets of DNA (cytosine-5) methylation-mediated transcriptional silencing using a novel conditionally active form of DNA methyltransferase 3aMichael S Samuel
Ludwig Institute for Cancer Research, P O Royal Melbourne Hospital, Parkville, Vic, Australia
Growth Factors 25:426-36. 2007.... - IL-6 regulates neutrophil trafficking during acute inflammation via STAT3Ceri A Fielding
Department of Nephrology, School of Medicine, Cardiff University, Cardiff, United Kingdom
J Immunol 181:2189-95. 2008.... - Molecular dissection of gp130-dependent pathways in hepatocytes during liver regenerationUta Dierssen
Internal Medicine III, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, Aachen, Germany
J Biol Chem 283:9886-95. 2008..In summary, gp130-dependent STAT3 activation and concomitant SOCS3 during liver regeneration is involved in timing of DNA synthesis and protects hepatocyte proliferation during stress conditions... - c-Myb is required for progenitor cell homeostasis in colonic cryptsJordane Malaterre
Peter MacCallum Cancer Centre and Pathology Department, University of Melbourne, Melbourne VIC 8006, Australia
Proc Natl Acad Sci U S A 104:3829-34. 2007.... - Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferationGeorge C T Yeoh
UWA Centre for Medical Research, The Western Australian Institute for Medical Research, Perth, Australia
Hepatology 45:486-94. 2007..Conclusion: Hyperactive STAT-3 signaling results in enhanced oval cell numbers, whereas ERK-1/2 activation suppresses oval cell proliferation... - Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)Gayle A Orner
Department of Environmental and Molecular Toxicology, 571 Weniger Hall, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA
Mutat Res 506:121-7. 2002..Collectively, the data support a chemopreventive role for tea and sulindac against intermediate and late stages of colon cancer, via effects on the beta-catenin/Tcf signaling pathway... - Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPKLing Zhao
Laboratory of Genetics and Physiology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:44093-100. 2004..These experiments establish that two distinct Stat3 signaling pathways emanating from gp130 are utilized in mammary tissue... - Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivoJodie Palmer
Prostate Centre at Vancouver General Hospital, Vancouver, BC, Canada
Prostate 62:282-9. 2005..In this study we analysed the NE differentiation process in vitro and in vivo using the LNCaP androgen dependent cell line via ligand independent induction of NE differentiation... - Interleukin-11 receptor signaling is required for normal bone remodelingNatalie A Sims
Department of Medicine at St Vincent s Hospital, The University of Melbourne, Fitzroy, Australia
J Bone Miner Res 20:1093-102. 2005..Furthermore, IL-11 signaling was not required for the effects of estradiol or estrogen deficiency on the mouse skeleton... - IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammationRachel M McLoughlin
Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, United Kingdom
Proc Natl Acad Sci U S A 102:9589-94. 2005..Consequently, STAT3 plays a defining role in IL-6-mediated T cell migration... - Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130Meegan Howlett
Department of Medicine, University of Melbourne at Western Hospital, Footscray, Australia
Gastroenterology 129:1005-18. 2005..This model recapitulates many characteristics of intestinal-type gastric cancer in humans... - CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPKMatthew J Watt
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, 3083, Australia
Nat Med 12:541-8. 2006.... - Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cellsChristiane Stuhlmann-Laeisz
Department of Biochemistry, , D-24098 Kiel, Germany
Mol Biol Cell 17:2986-95. 2006..Thus, L-gp130 can be used in vitro and in vivo to mimic constitutive and ligand-independent activation of gp130 and STAT3, the latter of which is frequently observed in neoplastic diseases... - Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous systemJason S Stumhofer
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
Nat Immunol 7:937-45. 2006..Thus IL-27, a potent inhibitor of T(H)-17 cell development, may be a useful target for treating inflammatory diseases mediated by these cells... - STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesisLouise M Judd
Department of Medicine, University of Melbourne at Western Hospital, Footscray 3001, Australia
Gastroenterology 131:1073-85. 2006..Furthermore, the interaction among STAT3, the microbial environment, and tumorigenesis was evaluated... - General nature of the STAT3-activated anti-inflammatory responseKarim C El Kasmi
Department of Infectious Diseases, St Jude s Children s Research Hospital, Memphis, TN 38105, USA
J Immunol 177:7880-8. 2006..We conclude that the AIR is a generic cytokine signaling pathway dependent on STAT3 but not unique to the IL-10R... - STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivoAntonello Pietrangelo
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico Via del Pozzo 71, 41100 Modena, Italy
Gastroenterology 132:294-300. 2007..To clarify the molecular pathways involved in hepcidin activation by IL-6, we used different mice strains in which the main IL-6/gp130 signaling pathways have been genetically disrupted... - The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression?Darryl A Knight
Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Ground Floor, E Block, Verdun Street, Nedlands, Western Australia, 6009, Australia
Pharmacol Ther 99:327-38. 2003..This may provide guides for the development of novel pharmacological treatment for fibroproliferative diseases... - AACR special meeting in cancer research: colon cancer--genetics to preventionCameron N Johnstone
Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Res 62:6779-83. 2002 - Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10Jason S Stumhofer
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Immunol 8:1363-71. 2007..This effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6. Our studies identify a previously unknown pathway that allows the immune system to temper inflammatory responses...