Research Topics
| Nicholas J HudsonSummaryCountry: Australia Publications
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Detail Information
Publications
Musical beauty and information compression: Complex to the ear but simple to the mind?Nicholas J Hudson
Computational and Systems Biology, CSIRO Livestock Industries, 306 Carmody Road, St, Lucia, Brisbane, Queensland 4067, Australia
BMC Res Notes 4:9. 2011..abstract:..
Eukaryotic evolutionary transitions are associated with extreme codon bias in functionally-related proteinsNicholas J Hudson
Computational and Systems Biology, CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia, Brisbane, Queensland, Australia
PLoS ONE 6:e25457. 2011..We propose that extreme codon bias in groups of genes that encode functionally related proteins has a pathway-level energetic explanation...
Lessons from an estivating frog: sparing muscle protein despite starvation and disuseNicholas J Hudson
Commonwealth Scientific and Industrial Research Organization Livestock Industries, 306 Carmody Rd, St Lucia, Brisbane, Queensland 4072, Australia
Am J Physiol Regul Integr Comp Physiol 290:R836-43. 2006..Pyruvate dehydrogenase kinase 4 transcription was fourfold lower in estivators (P = 0.11), implying that, in contrast to mammalian hibernators, this enzyme does not drive the combustion of lipids that helps spare hypometabolic muscle...
Epigenetic silencers are enriched in dormant desert frog muscleNicholas J Hudson
CSIRO Livestock Industries, Brisbane, QLD, Australia
J Comp Physiol B 178:729-34. 2008....
Skeletal muscle extracellular matrix remodelling after aestivation in the green striped burrowing frog, Cyclorana alboguttataNicholas J Hudson
CSIRO Livestock Industries, 306 Carmody Road, St Lucia, Brisbane, Queensland 4072, Australia
Comp Biochem Physiol A Mol Integr Physiol 146:440-5. 2007..Their main impact is to maintain proportional representation of extracellular matrix components of skeletal muscle and therefore preserve the active frog phenotype...
Inferring the transcriptional landscape of bovine skeletal muscle by integrating co-expression networksNicholas J Hudson
Food Futures Flagship and Livestock Industries, Commonwealth Scientific and Industrial Research Organisation, Queensland Bioscience Precinct, St Lucia, Brisbane, Queensland, Australia
PLoS ONE 4:e7249. 2009..In muscle a small number of well characterised transcription factors are proposed to regulate development. Therefore, muscle appears to be a tractable system for proposing new computational approaches...
Activity, abundance, distribution and expression of Na+/K+-ATPase in the salt glands of Crocodylus porosus following chronic saltwater acclimationRebecca L Cramp
School of Biological Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
J Exp Biol 213:1301-8. 2010..These data suggest that either chronic SW acclimation does not affect NKA in crocodile salt glands in the same manner as seen in other models or crocodiles possess the capacity to moderate NKA activity following prolonged exposure to SW...
Role of calcium and vesicle-docking proteins in remobilising dormant neuromuscular junctions in desert frogsNickolas A Lavidis
School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:27-37. 2008..Neuromuscular remobilisation after dormancy in C. alboguttata is more likely a product of rapidly reversible physiologic mechanisms than reorganisations of the neuromuscular transcriptome...
Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscleQuan Gu
Computational and Systems Biology, CSIRO Food Futures Flagship and CSIRO Livestock Industries, 306 Carmody Rd, St Lucia, Brisbane, Queensland 4067, Australia
BMC Genomics 12:23. 2011..To better understand how the genetic code controls gene expression in bovine muscle we associated gene expression data from developing Longissimus thoracis et lumborum skeletal muscle with bovine promoter sequence information...
Skeletal muscle atrophy occurs slowly and selectively during prolonged aestivation in Cyclorana alboguttata (Gunther 1867)Beth L Mantle
University of Queensland, St Lucia, Australia
J Exp Biol 212:3664-72. 2009....
A differential wiring analysis of expression data correctly identifies the gene containing the causal mutationNicholas J Hudson
Food Futures Flagship and Livestock Industries, Commonwealth Scientific and Industrial Research Organisation, Queensland Bioscience Precinct, St Lucia Brisbane, Queensland, Australia
PLoS Comput Biol 5:e1000382. 2009..In contrast to other published methods that compare co-expression networks, significance testing is not used to eliminate connections...
Regulatory impact factors: unraveling the transcriptional regulation of complex traits from expression dataAntonio Reverter
Bioinformatics Group, CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, Brisbane, Queensland 4067, Australia
Bioinformatics 26:896-904. 2010..We argue that RIF has universal applicability, and advocate its use as a promising hypotheses generating tool for the systematic identification of novel TF not yet documented as critical...
Surviving the drought: burrowing frogs save energy by increasing mitochondrial couplingSara M Kayes
School of Biological Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
J Exp Biol 212:2248-53. 2009..Cyclorana alboguttata can survive in a dormant state for several years and we propose the hypothesis that energy efficiency is increased during aestivation...
Obese humans as economically designed feed converters: symmorphosis and low oxidative capacity skeletal muscleNicholas J Hudson
CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, Brisbane, Queensland, Australia
Med Hypotheses 70:693-7. 2008....
Effect of prolonged inactivity on skeletal motor nerve terminals during aestivation in the burrowing frog, Cyclorana alboguttataNicholas J Hudson
School of Life Sciences, The University of Queensland, QLD, Brisbane 4072, Australia
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191:373-9. 2005..The impact of this suite of neuromuscular characteristics on the locomotor performance of emergent frogs is discussed...
Gene expression studies of developing bovine longissimus muscle from two different beef cattle breedsSigrid A Lehnert
Cooperative Research Centre for Cattle and Beef Quality, Australia
BMC Dev Biol 7:95. 2007....
Effect of aestivation on long bone mechanical properties in the green-striped burrowing frog, Cyclorana alboguttataNicholas J Hudson
School of Life Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
J Exp Biol 207:475-82. 2004..This preservation of bone tissue properties enables C. alboguttata to compress the active portions of their life history into unpredictable windows of opportunity, whenever heavy rains occur...
A gene coexpression network for bovine skeletal muscle inferred from microarray dataAntonio Reverter
Bioinformatics Group, Commonwealth Scientific and Industrial Research Organisation Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, QLD 4067, Australia
Physiol Genomics 28:76-83. 2006..Our results not only recapitulate the known biology of muscle but have also started to reveal some of the underlying associations between and within the structural components of skeletal muscle...
Maintaining muscle mass during extended disuse: aestivating frogs as a model speciesNicholas J Hudson
Physiological Ecology Laboratory, Department of Zoology and Entomology, The University of Queensland, Brisbane, QLD 4072, Australia
J Exp Biol 205:2297-303. 2002..In the light of these findings, the role of reactive oxygen species and antioxidants during muscle disuse is emphasised...
The effects of saltwater acclimation on neurotransmitters in the lingual salt glands of the estuarine crocodile, Crocodylus porosusRebecca L Cramp
School of Integrative Biology, The University of Queensland, St Lucia, 4072, Queensland, Australia
Regul Pept 140:55-64. 2007..In addition, we sought to determine whether there was any evidence for the adaptation of the C. porosus salt gland nervous system to hyperosmotic conditions...
Preservation of three-dimensional capillary structure in frog muscle during aestivationNicholas J Hudson
The School of Life Sciences, The University of Queensland, Brisbane 4072, Australia
J Anat 202:471-4. 2003..alboguttata. The preservation of capillary structure in the hindlimb muscles of C. alboguttata in part accounts for their remarkable ability to emerge with a fully competent locomotor system after prolonged immobilization...
