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Species | A Mackay-SimSummaryAffiliation: Griffith University Country: Australia Publications
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Publications
Olfactory ensheathing cells and spinal cord repairAlan Mackay-Sim
Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD, Australia
Keio J Med 54:8-14. 2005..After devising methods to grow human olfactory ensheathing cells from nasal biopsy we recently initiated a Phase I clinical trial of transplantation into the human paraplegic spinal cord...- Australian norms for a quantitative olfactory function testAlan Mackay-Sim
School of Biomolecular and Biomedical Science, Center for Molecular Neurobiology, Griffith University, Brisbane, QLD 4111, Australia
J Clin Neurosci 11:874-9. 2004..With these norms, the Sniffin' Sticks can be used in the Australian population to compare an individual's olfactory function against the population of others of similar age and sex and to identify olfactory dysfunction... - Olfactory ensheathing cells from the nose: clinical application in human spinal cord injuriesAlan Mackay-Sim
National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith Unversity, Brisbane, QLD 4111, Australia
Exp Neurol 229:174-80. 2011..This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair... - Stem cells and their niche in the adult olfactory mucosaA Mackay-Sim
National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
Arch Ital Biol 148:47-58. 2010..Whether this is an additional stem cell or the horizontal basal cell is still an open question... - Stem cells and genetic diseaseA Mackay-Sim
National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD, Australia
Cell Prolif 41:85-93. 2008..These properties, combined with the possibility of autologous transplantation, indicate significant advantages over embryonic stem cells in many proposed clinical applications... - Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trialA Mackay-Sim
National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD, Australia
Brain 131:2376-86. 2008.... - Altered adhesion, proliferation and death in neural cultures from adults with schizophreniaF Feron
School of Biomolecular and Biomedical Science, Griffith University, Nathan, QLD, Australia
Schizophr Res 40:211-8. 1999..69% in the patients compared to 0.29% in the controls; and 3. dopamine (10 microM) significantly increased the proportion of apoptotic cells in the control cultures but significantly decreased the proportion in patients' cultures... - Dopamine promotes differentiation of olfactory neuron in vitroF Feron
Center for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Nathan, Australia
Brain Res 845:252-9. 1999..Altogether these data indicate that, in parallel to its action in odour processing, dopamine plays a growth factor-like role in the permanent neurogenesis observed in the olfactory epithelium... - Vitamin D3 and brain developmentD Eyles
Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Brisbane, Queensland 4076, Australia
Neuroscience 118:641-53. 2003..Our findings would suggest that low maternal vitamin D(3) has important ramifications for the developing brain... - Differentiation in an olfactory cell line. Analysis via differential displayS P Zehntner
School of Biomolecular and Biomedical Sciences, Griffith University, Brisbane, Australia
Ann N Y Acad Sci 855:235-9. 1998..Both the known and the unknown sequences are being studied further to provide insight into the differentiation of olfactory neurons... - Neurotrophin expression in the adult olfactory epitheliumF Feron
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, QLD 4111, Australia
Brain Res 1196:13-21. 2008..These findings confirm that neurotrophins are produced within the olfactory epithelium, suggesting autocrine and paracrine regulation of olfactory neurogenesis... - Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epitheliumP Hsu
Centre for Molecular Neurobiology, School of Biomedical and Biomolecular Science, Griffith University, QLD 4111, Brisbane, Australia
Brain Res 896:188-97. 2001..The widespread distribution of receptors suggests that fibroblast growth factors may have roles other than proliferation of globose basal cells... - Vascular endothelial growth factor and platelet derived growth factor modulates the glial response to a cortical stab injuryA Norazit
National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, 4111 Brisbane, Queensland, Australia
Neuroscience 192:652-60. 2011..Thus, VEGF and PDGF applied at the same time as a stab injury to the brain initially delayed the inflammatory response up to day 5 but evoked a persistent astrogliosis and microglial response up to 60 days... - Development of voltage-dependent currents in taste receptor cellsA Mackay-Sim
Faculty of Science and Technology, Griffith University, Nathan, QLD, Australia
J Comp Neurol 365:278-88. 1996..These data suggest that contact with the taste pore is required for the development of inward currents in taste cells... - Multipotent stem cells from adult olfactory mucosaWayne Murrell
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Australia
Dev Dyn 233:496-515. 2005..These results demonstrate the existence of a multipotent stem-like cell in the olfactory mucosa useful for autologous transplantation therapies and for cellular studies of disease... - Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cordJike Lu
Neural Injury Research Unit, School of Anatomy, University of New South Wales, Sydney Australia
Brain 125:14-21. 2002..Olfactory ensheathing cells are accessible and available in the human nose; the present study further supports clinical use of these cells in repairing the human spinal cord via autologous transplantation... - Olfactory neural cells: an untapped diagnostic and therapeutic resource. The 2000 Ogura LectureChristopher Perry
Department of Surgery, University of Queensland, Australia
Laryngoscope 112:603-7. 2002..This is an overview of the cellular biology of upper nasal mucosal cells that have special characteristics that enable them to be used to diagnose and study congenital neurological diseases and to aid neural repair... - A novel cell transplantation protocol and its application to an ALS mouse modelEri Morita
Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
Exp Neurol 213:431-8. 2008..We conclude that intrathecal transplantation could be a promising way to deliver donor cells to the central nervous system. Further experiments to elucidate relevant conditions for optimal outcomes are required... - Neurotrophin 3 promotes purification and proliferation of olfactory ensheathing cells from human noseJohn I Bianco
Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Nathan, Queensland 4111, Australia
Glia 45:111-23. 2004..This technique opens the door for clinical trials in which nasal ensheathing cells will be autotransplanted in humans suffering from nerve injury... - Paradoxical association between smoking and olfactory identification in psychosis versus controlsDuncan McLean
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland, 4076, Australia
Aust N Z J Psychiatry 38:81-3. 2004..Deficits in olfactory identification have been demonstrated in patients with schizophrenia. This study examined the interaction between smoking and olfactory identification in patients with psychotic disorders versus well controls... - Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J miceLauren R Harms
School of Biomedical Sciences, Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland 4072, Australia
Behav Brain Res 187:343-50. 2008.... - Maternal vitamin D depletion alters neurogenesis in the developing rat brainXiaoying Cui
School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia
Int J Dev Neurosci 25:227-32. 2007..These results show that vitamin D can regulate cell proliferation in the developing brain. Further studies are warranted to examine the underlying mechanisms for these findings... - Regulation of adult olfactory neurogenesis by insulin-like growth factor-IRichard D McCurdy
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111, Australia
Eur J Neurosci 22:1581-8. 2005..These effects appear to be similar to the cellular effects of IGF-I in the developing nervous system... - Behavioural characterization of vitamin D receptor knockout miceThomas H J Burne
Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
Behav Brain Res 157:299-308. 2005..Therefore, it appears that VDR -/- mice have muscular and motor impairments that significantly affects locomotor behaviour but seemingly no impairments in cognition as indicated by exploration, working memory or anxiety... - Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult ratsThomas H J Burne
Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, QLD 4111, Australia
Behav Brain Res 154:549-55. 2004..Thus, transient prenatal Vitamin D deficiency induces hyperlocomotion in adulthood, without severe motor abnormalities... - Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of acoustic startleThomas H J Burne
Centre for Molecular Neurobiology, School of Biomolecular and Biomedical Science, Griffith University, Brisbane, Queensland 4111, Australia
Physiol Behav 81:651-5. 2004..We conclude that combined prenatal and chronic postnatal hypovitaminosis D, but not early life hypovitaminosis D, alters PPI... - Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analysesRichard D McCurdy
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111, Australia
Schizophr Res 82:163-73. 2006.... - Swimming behaviour and post-swimming activity in Vitamin D receptor knockout miceThomas H J Burne
Neurobiology Program, Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111, Australia
Brain Res Bull 69:74-8. 2006..Differences in muscle strength may confound tests of activity that are used to infer an "anxious" phenotype... - Survival and migration of human and rat olfactory ensheathing cells in intact and injured spinal cordChao Deng
Neural Injury Research Unit, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
J Neurosci Res 83:1201-12. 2006..OECs migrated less in animals with a concomitant contralateral hemisection... - Olfactory ability in the healthy population: reassessing presbyosmiaAlan Mackay-Sim
School of Nursing and Midwifery, Griffith University, Brisbane, Queensland 4111, Australia
Chem Senses 31:763-71. 2006..The power of this approach is that it provides a normative data set against which many factors such as medication schedules and pathological conditions can be compared... - Effect of clarithromycin on nuclear factor-kappa B and transforming growth factor-beta in chronic rhinosinusitisBen Wallwork
School of Biomolecular and Biomedical Science, Griffith University, Brisbane, Australia
Laryngoscope 114:286-90. 2004..In this study, the effect of clarithromycin treatment on the expression of transforming growth factor (TGF)-beta and the key pro-inflammatory nuclear transcription factor, NF-kappa B, was examined in vitro and in vivo... - A Role for ARF6 and ARNO in the regulation of endosomal dynamics in neuronsDelia Hernandez-Deviez
Department of Cell Biology and Anatomy, University of Arizona, Arizona Health Sciences Center, PO Box 245044, Tucson, AZ 85724, USA
Traffic 8:1750-64. 2007..These results suggest that endotubin labels a distinct endosomal structure in neurons and that ARNO and ARF6 mediate neurite extension through the regulation of this compartment... - Developmental vitamin D deficiency alters brain protein expression in the adult rat: implications for neuropsychiatric disordersLionel Almeras
Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, CNRS UMR 6184, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
Proteomics 7:769-80. 2007....