Research Topics
Genomes and Genes
| Christopher J OrmandySummaryAffiliation: Garvan Institute of Medical Research Country: Australia Publications
| Collaborators
|
Detail Information
Publications
The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epitheliumSamantha R Oakes
Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia
Breast Cancer Res 8:207. 2006..Here we review the current understanding of the components of the alveolar switch and conclude with an examination of the role of the ets transcription factor Elf5. We propose that Elf5 is a key regulator of the alveolar switch...- Gata-3 and mammary cell fateMatthew J Naylor
Cancer Research Program, Garvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010 Australia
Breast Cancer Res 9:302. 2007..These reports offer an understanding of how mammary cells assume and maintain a variety of cell behaviours and functions, and how a mammary cell may potentially subvert these constraints during carcinogenesis... - Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 micePalaniappan Ramanathan
Centre for Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia
BMC Genomics 9:197. 2008..The QSi5 inbred strain of mice was selected for high fecundity and low inter-litter interval, and is very successful at weaning large numbers of offspring when compared to other inbred strains... - Investigation of the transcriptional changes underlying functional defects in the mammary glands of prolactin receptor knockout miceChristopher J Ormandy
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst Sydney, NSW 2010, Australia
Recent Prog Horm Res 58:297-323. 2003..Such profiling has identified a number of genes with well-characterized roles in mammary development, in addition to a number of novel transcripts... - Identification of downstream targets of estrogen and c-myc in breast cancer cellsElizabeth A Musgrove
Cancer Research Program, Garvan Institute, Darlinghurst, Sydney, Australia
Adv Exp Med Biol 617:445-51. 2008..These data indicate that a significant component of E-induced mitogenesis is mediated by c-myc and that selected c-myc target genes may be surrogate markers of c-myc expression in BC... - The Ets transcription factor Elf5 specifies mammary alveolar cell fateSamantha R Oakes
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
Genes Dev 22:581-6. 2008..Thus Elf5 specifies the differentiation of CD61+ progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development... - Socs2 and elf5 mediate prolactin-induced mammary gland developmentJessica Harris
Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, New South Wales 2010, Australia
Mol Endocrinol 20:1177-87. 2006..Thus, Socs2 and Elf5 are key members of the set of prolactin-regulated genes that mediate prolactin-driven mammary development... - Transcriptional changes underlying the secretory activation phase of mammary gland developmentMatthew J Naylor
Development Group, Cancer Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, New South Wales 2010, Australia
Mol Endocrinol 19:1868-83. 2005.... - KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signallingHeidi N Hilton
Development Group, Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
Biochim Biophys Acta 1783:383-93. 2008..Thus KIBRA may play a role in how the reproductive state influences the mammary epithelial cell to respond to changing cell-context information, such as experienced during the tissue remodeling events of mammary gland development... - Meta-analysis and gene set enrichment relative to er status reveal elevated activity of MYC and E2F in the "basal" breast cancer subgroupM Chehani Alles
Cancer Research Program, Garvan Institute of Medical Research, Sydney, Australia
PLoS ONE 4:e4710. 2009..These features further distinguish estrogen receptor negative (ER-) tumor subtypes, but targeted therapy is currently limited to tumors over-expressing the ErbB2 receptor... - Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancerElizabeth A Musgrove
Cancer Research Program, Garvan Institute of Medical Research, Sydney, Australia
PLoS ONE 3:e2987. 2008..Endocrine therapies targeting the estrogen receptor are effective in breast cancer, but their success is limited by intrinsic and acquired resistance... - The neuropeptide galanin augments lobuloalveolar developmentMatthew J Naylor
Development Group, Cancer Research Program and Neurobiology Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
J Biol Chem 278:29145-52. 2003..These data establish a new role for galanin as a hormone augmenting mammary development during pregnancy in concert with prolactin... - Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout miceElizabeth A Musgrove
Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
J Mammary Gland Biol Neoplasia 9:55-66. 2004..In this review we summarize these and other data addressing the role of p27 in normal mammary epithelium and experimental models of mammary carcinogenesis... - The cyclin-dependent kinase inhibitor p27 (Kip1) regulates both DNA synthesis and apoptosis in mammary epithelium but is not required for its functional development during pregnancyElizabeth A Davison
Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
Mol Endocrinol 17:2436-47. 2003..However, the absence of morphological and cellular defects in p27-/- mammary tissue during pregnancy raises the possibility that loss of p27 in breast cancer may not confer an overall growth advantage unless apoptosis is also impaired... - Prolactin and the prolactin receptor: new targets of an old hormoneJessica Harris
Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Ann Med 36:414-25. 2004..Further knockout models have provided insight into the importance of PRL signaling intermediates and the advent of transcript profiling has allowed the elucidation of a number of PRL target genes... - c-Myc overexpression and endocrine resistance in breast cancerCatriona M McNeil
Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
J Steroid Biochem Mol Biol 102:147-55. 2006.... - Lineage specific methylation of the Elf5 promoter in mammary epithelial cellsHeather J Lee
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Stem Cells 29:1611-9. 2011.... - Prolactin regulates mammary epithelial cell proliferation via autocrine/paracrine mechanismMathew J Naylor
Cancer Research Program, The Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
Endocrine 20:111-4. 2003..Thus, mammary-derived PRL influences mammary epithelial cell proliferation via an autocrine/paracrine mechanism, establishing a physiologic function for mammary PRL during mammopoiesis... - Prostate development and carcinogenesis in prolactin receptor knockout miceFiona G Robertson
Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
Endocrinology 144:3196-205. 2003..These findings establish essential though subtle roles for prolactin in the regulation of prostate morphology, gene expression, SV40T-induced neoplasia, and reproductive function... - Prolactin regulation of mammary gland developmentSamantha R Oakes
Development Group, Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia
J Mammary Gland Biol Neoplasia 13:13-28. 2008..Here we focus on providing an over-view of prolactin action during development of the model murine mammary gland... - Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient miceGregory J Cooney
Diabetes and Obesity, Garvan Institute of Medical Research, Sydney, NSW, Australia
EMBO J 23:582-93. 2004.... - High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtypeSarah J Zardawi
Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, NSW, Australia
Histopathology 56:286-96. 2010..However, there is little information regarding the expression of Notch1 in premalignant lesions and early breast cancer. We investigated expression of Notch1 in breast cancer development and its association with molecular subtypes... - Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancerSandra A O'Toole
Cancer Research, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Cancer Res 71:4002-14. 2011..Blockade of Hh signaling to peritumoral stromal cells may represent a novel therapeutic approach in some basal-like breast cancers... - Mouse strain-specific patterns of mammary epithelial ductal side branching are elicited by stromal factorsMatthew J Naylor
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Dev Dyn 225:100-5. 2002..Regardless of underlying mechanism, transplantation without regard to the genetic background of the stromal donor, whether inbred or mixed, will compromise experiments with side branching and associated gene expression endpoints... - Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusionDarren N Saunders
Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, 2010 NSW, Australia
Mol Cell Biol 24:7225-34. 2004..Hence, Edd has an essential role in extraembryonic development... - Y4 receptor knockout rescues fertility in ob/ob miceAmanda Sainsbury
Neurobiology Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, Sydney NSW 2010, Australia
Genes Dev 16:1077-88. 2002..These data suggest that central Y4 receptor signaling specifically inhibits reproductive function under conditions of elevated central NPY-ergic tonus... - Genomic telescopesChristopher J Ormandy
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, Australia
J Mammary Gland Biol Neoplasia 8:255-6. 2003 - Cyclin D1, EMS1 and 11q13 amplification in breast cancerChristopher J Ormandy
Cancer Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, NSW, Australia
Breast Cancer Res Treat 78:323-35. 2003.... - Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissueLouise Nilsson
Department of Physiology, Goteborg University, 405 30 Goteborg, Sweden
Biochem Biophys Res Commun 331:1120-6. 2005..Decreased serum adiponectin levels have been associated with insulin resistance, and our data in human tissue and in transgenic mice suggest a role for adiponectin in PRL and GH induced insulin resistance... - Local insulin-like growth factor-II mediates prolactin-induced mammary gland developmentRussell C Hovey
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1402, USA
Mol Endocrinol 17:460-71. 2003..Together, these data demonstrate a role for IGF-II as a mediator of PRL action in the mouse mammary gland during ductal branching and alveolar development... - Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar developmentSandra L Grimm
Department of Molecular and Cellular Biology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Mol Endocrinol 16:2675-91. 2002..Together, these data suggest that C/EBPbeta is a master regulator of mammary epithelial cell fate and that the correct spatial pattern of PR and PrlR expression is a critical determinant of hormone-regulated cell proliferation... - The role of prolactin and growth hormone in mammary gland developmentPaul A Kelly
INSERM Unit 344 Molecular Endocrinology, Faculty of Medicine Necker, Paris, France
Mol Cell Endocrinol 197:127-31. 2002..In summary, it is now established that GH and PRL activate Stat5 in separate compartments, reflecting their specific roles in ductal and alveolar development and differentiation... - Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactationJiong Zhou
Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
EMBO J 24:635-44. 2005..Our data demonstrate that Elf5 is essential for developmental processes in the embryo and in the mammary gland during pregnancy...