Research Topics
Species | Jim ToouliSummaryAffiliation: Flinders University Country: Australia Publications
| Collaborators
|
Detail Information
Publications
Guidelines for the management of acute pancreatitisJ Toouli
Flinders University, Adelaide, Australia
J Gastroenterol Hepatol 17:S15-39. 2002- Biliary scintigraphy versus sphincter of Oddi manometry in patients with post-cholecystectomy pain: is it time to disregard the scan?James Toouli
Flinders University, Flinders Medical Centre, South Australia
Curr Gastroenterol Rep 7:154-9. 2005..Consequently, the quest for development of a noninvasive investigation for diagnosis of SO dysfunction continues. In the mean time, improved manometric techniques that enhance reproducibility and reduce complications have been developed... - Sphincter of Oddi: Function, dysfunction, and its managementJames Toouli
Flinders University of South Australia, Adelaide, Bedford Park SA 5042, Australia
J Gastroenterol Hepatol 24:S57-62. 2009..The most effective treatment once an abnormal basal pressure is identified is division of the sphincter. This is associated with good long-term results... - Training surgeon scientistsJames Toouli
Department of General and Digestive Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia
ANZ J Surg 73:630-2. 2003..A significant number of publications have resulted from the College-funded research. At this early stage, the programme for creating surgeon scientists appears to be on track... - Management of pancreatic exocrine insufficiency: Australasian Pancreatic Club recommendationsJames Toouli
Department of Surgery, Flinders Medical Centre, Adelaide, SA, Australia
Med J Aust 193:461-7. 2010..Medium-chain triglycerides do not provide any clear nutritional advantage over long-chain triglycerides, but can be trialled in patients who fail to gain or to maintain adequate bodyweight in order to increase energy intake... - GallstonesJ Toouli
Department of Surgery, Flinders Medical Centre, Adelaide, SA
Med J Aust 169:166-71. 1998..Bile duct stones are mostly diagnosed by operative cholangiography at cholecystectomy. Open surgery is used when minimal-access techniques are dangerous, unsuitable or impossible... - Efficacy of a low-pressure laparoscopic adjustable gastric band for morbid obesity: patients at long term in a multidisciplinary centerJim Toouli
Adelaide Bariatric Center and Flinders University, Adelaide, South Australia, Australia
Surg Obes Relat Dis 4:S31-8. 2008..The current study sought to determine the long-term safety and efficacy of a low-pressure LAGB... - Change in liver size and fat content after treatment with Optifast very low calorie dietMark C Lewis
Department of General and Digestive Surgery, Flinders Medical Centre, Flinders University of South Australia, Bedford Park, South Australia, Australia
Obes Surg 16:697-701. 2006..This suggests that the reduction in liver volume is due to loss of fat. The reduction in liver fat and volume likely accounts for the perceived improved operability in patients undergoing LAGB... - Abdominal adiposity and liver fat content 3 and 12 months after gastric banding surgeryMadeleine L Heath
Department of Medicine, Flinders Medical Centre, Flinders University, Bedford Park 5042, South Australia
Metabolism 58:753-8. 2009.... - Effects of diaspirin cross-linked hemoglobin on motor function of the duodenum and biliary system in the Australian brush-tailed possum in vivoH Konomi
Department of General and Digestive Surgery, Centre for Neuroscience, Flinders University of South Australia, Adelaide, South Australia, Australia
J Pharmacol Exp Ther 296:1067-73. 2001..DCLHb-induced changes were not evident in the presence of L-NAME. These findings suggest that DCLHb affects duodenal and trans-sphincteric flow predominantly by NO scavenging... - The early effects of weight loss surgery on regional adiposityMadeleine L Phillips
Department of Medicine, Flinders Medical Centre, Flinders University of South Australia, Bedford Park, South Australia
Obes Surg 15:1449-55. 2005..Because the rate of weight loss is greatest in the first 3 months after LAGB, we investigated the impact of LAGB on changes in regional lipid deposition and insulin sensitivity over this period... - Relative effects of dihydropyridine L-type calcium channel antagonism on biliary, duodenal, and vascular tissues: an in vivo and in vitro analysis in Australian brush-tailed possumA G Craig
Department of General and Digestive Surgery, Flinders University, Bedford Park, South Australia
Dig Dis Sci 47:2029-36. 2002..In conclusion, in the possum we found that L-type channel antagonism in vivo was more potent to the vasculature than the sphincter of Oddi but this was not confirmed in vitro... - Scorpion venom stimulates biliary/duodenal motility and pancreatic exocrine secretionJ W C Chen
Department of General and Digestive Surgery, Pancreatobiliary Research Group, Flinders Medical Centre, Flinders University, Bedford Park, SA 5042, Australia
Neurogastroenterol Motil 16:447-54. 2004..These changes may contribute to gastrointestinal symptoms associated with early phases of envenomation... - A2A and A3 receptors mediate the adenosine-induced relaxation in spontaneously active possum duodenum in vitroC M Woods
Department of General and Digestive Surgery, Centre for Neuroscience, Flinders Medical Centre, Flinders University of South Australia, PO Box 2100, Adelaide 5001, Australia
Br J Pharmacol 138:1333-9. 2003..5. In conclusion, exogenous adenosine reduced duodenal longitudinal motor activity via A(2A) and A(3) receptors. Our findings suggest that endogenous purines may modulate spontaneous duodenal motor activity... - Exogenous purines induce differential responses in the proximal and distal regions of the possum sphincter of OddiC M Woods
Pancreatobiliary Research Group, Department of General and Digestive Surgery, Flinders University, Flinders Medical Centre, Bedford Park, SA 5042, Australia
Auton Autacoid Pharmacol 27:27-38. 2007..7. Exogenous purines modulate SO motility, acting primarily in the proximal region of the SO, via neural and non-neural mechanisms and multiple purine receptor subtypes... - Sphincter of Oddi function and dysfunctionJ Toouli
Flinders Medical Centre, Adelaide, South Australia
Can J Gastroenterol 14:411-9. 2000..Division of the sphincter is an effective treatment for patients with manometrically proven SO stenosis for either the biliary or pancreatic form of the disorder. Other forms of SO dysfunction may benefit from pharmacotherapy... - Exogenous adenosine triphosphate and adenosine stimulate proximal sphincter of oddi motility via neural mechanisms in the anesthetized Australian possumC M Woods
Pancreatobiliary Research Group, Department of General and Digestive Surgery, Flinders Medical Centre, Bedford Park, SA 5042, Australia
Dig Dis Sci 51:1347-56. 2006..Adenosine triphosphate may further modulate sphincter motility via nicotinic and nitrergic pathways... - Development of a sleeve sensor for measurement of sphincter of Oddi motilityA G Craig
Dept of General and Digestive Surgery, Flinders Medical Centre, Bedford Park, South Australia, Australia 5042
Endoscopy 33:651-7. 2001..The sleeve sensor is a perfused channel which records the highest pressure point along its length. The aim of the study was to develop and evaluate a prototype sleeve sensor for SO manometry... - Endothelin-1 stimulates sphincter of Oddi motility and decreases trans-sphincteric flow: a possible mechanism contributes to cholestasis in disease statesJ W C Chen
Department of General and Digestive Surgery, Centre for Digestive Sciences, Flinders University, Flinders Medical Centre, Australia
Neurogastroenterol Motil 15:393-400. 2003..001). In vitro studies showed a significant increase in mean SO motility index, and frequency of contractions at higher ET-1 concentrations (10-9-10-7 mol L-1). ET-1 is a potent stimulator of SO motility resulting in a reduction in TSF... - Endothelin-1 induces contraction of human and Australian possum gallbladder in vitroB O Al-Jiffry
Department of General and Digestive Surgery, Centre for Digestive Science and Centre for Neuroscience, Flinders University of South Australia, PO Box 2100, SA 5001, Adelaide, Australia
Regul Pept 102:31-9. 2001..Endothelin-1 (ET-1) stimulates guinea pig gallbladder (GB) muscle strip contractility; however, the role and source of ET-1 in the GB remains to be elucidated... - Inhibitory motor innervation of the gall bladder musculature by intrinsic neurones containing nitric oxide in the Australian brush-tailed possum (Trichosurus vulpecula)A C Meedeniya
Department of General and Digestive Surgery, Centre for Digestive Health and Centre for Neuroscience, Flinders University of South Australia, Flinders Medical Centre, Bedford Park, Adelaide, SA 5042, Australia
Gut 49:692-8. 2001..Data are available on the neurochemical composition of intrinsic and extrinsic nerves innervating the gall bladder but are lacking on specific functional classes of gall bladder neurones... - Secretin induces variable inhibition of motility in different parts of the Australian possum sphincter of OddiB O Al-Jiffry
Department of General and Digestive Surgery, Flinders University of South Australia, Adelaide, Australia
Neurogastroenterol Motil 13:449-55. 2001..TTX enhanced the secretin-induced response to the same level at the four sites (P < 0.02). We conclude that secretin inhibits the motility of the possum SO in a nonuniform manner and is modulated by neural activity... - Effects of acute pancreatic duct obstruction on pancreatic perfusion: implication of acute pancreatic duct decompressionC X Shi
Dept. of General and Digestive Surgery, Flinders Medical Centre, Flinders University of South Australia, Bedford Park, Australia
Scand J Gastroenterol 37:1328-33. 2002..05). CONCLUSION: In patients with acute pancreatitis due to obstructive causes, early decompression of the PD may prevent early pancreatic ischaemia... - Distribution of nitric oxide synthase and vasoactive intestinal polypeptide immunoreactivity in the sphincter of Oddi and duodenum of the possumM E Simula
Department of General and Digestive Surgery, Flinders Medical Center, Flinders University, Adelaide, South Australia
Cell Tissue Res 304:31-41. 2001..Thus, the possum possesses an extensive NOS innervation of the SO and duodenum, with a significantly higher proportion of NOS-IR neurons within the SO, a subset of which contains VIP... - Selective iNOS inhibition enhances spontaneous gallbladder motility in the Australian possumC M Woods
Department of General and Digestive Surgery, Flinders Medical Centre, Flinders University, Adelaide, SA, Australia
Neurogastroenterol Motil 19:497-503. 2007..AR-C may be a beneficial treatment for patients suffering from acute cholecystitis... - Induction of duodenal motility activates the sphincter of Oddi (SO)-duodenal reflex in the Australian possum in vitroH Konomi
Department of General and Digestive Surgery, Centre for Digestive Sciences and the Centre for Neuroscience, Flinders Medical Centre, Flinders University, PO Box 2100, Adelaide 5000, South Australia, Australia
Auton Autacoid Pharmacol 22:109-17. 2002..These findings support the role for the SO-duodenal reflex in preventing duodenobiliary/pancreatic reflux during periods of elevated duodenal activity... - Endogenous endothelin increases gallbladder tone and leads to acute cholecystitis in the Australian possumB O Al-Jiffry
Department of General and Digestive Surgery, Center for Digestive Science, Flinders University, Bedford Park, SA, Australia
Neurogastroenterol Motil 16:125-33. 2004..This increase was reduced by tezosentan treatment. Gallbladder endothelin production is an early event in acute cholecystitis, increases gallbladder tone and plays a crucial role in the inflammatory process... - Scintigraphy versus manometry in patients with suspected biliary sphincter of Oddi dysfunctionA G Craig
Department of General and Digestive Surgery, Flinders University, South Australia, Australia
Gut 52:352-7. 2003..CONCLUSIONS: Our findings indicate that scintigraphy using these methods of analysis correlates poorly with manometry in post cholecystectomy patients with suspected biliary SO dysfunction... - Sphincter of Oddi dysfunction associated with choledochal cystA G Craig
Department of General and Digestive Surgery, Flinders Medical Center, Adelaide, Australia
J Gastroenterol Hepatol 16:230-4. 2001..This report suggests an association between the choledochal cyst and sphincter of Oddi dysfunction, and may suggest that SO dysfunction plays a role in choledochal cyst formation... - Characterization of the intrinsic and extrinsic innervation of the gall bladder epithelium in the Australian Brush-tailed possum (Trichosurus vulpecula)A C B Meedeniya
Department of General and Digestive Surgery, Centre for Neuroscience, Flinders University, Flinders Medical Centre, Australia
Neurogastroenterol Motil 15:383-92. 2003..Some of the NOS-immunoreactive neurones of the subepithelial plexus also contained VIP and/or SP. Gall bladder subepithelial plexus neurones, containing NOS and/or VIP/SP, innervate the epithelium, as do extrinsic neurones... - A simple scoring system for predicting bile duct stones in patients with cholelithiasisH M Soltan
Department of General and Digestive Surgery, Flinders Medical Centre, Bedford Park, Adelaide, SA 5042, Australia
J Gastrointest Surg 5:434-7. 2001..The use of such a score may allow the development of preoperative strategies for treating patients undergoing laparoscopic cholecystectomy... - Sphincter of Oddi function in the Australian brush-tailed possum is inhibited by intragastric ethanolY Sonoda
Pancreatobiliary Research Group, Department of General and Digestive Surgery, Flinders University, Flinders Medical Centre, Bedford Park, Australia
Neurogastroenterol Motil 19:401-10. 2007..We conclude that ethanol (and/or its metabolites) reduces TSF via humoral and neural mechanisms involving vagal pathways, muscarinic receptors and nitric oxide. Reduced TSF could contribute to the onset of AP... - The sphincter of Oddi: understanding its control and functionC M Woods
Pancreatobiliary Research Group, Department of General and Digestive Surgery, Flinders University, Flinders Medical Centre, Bedford Park, Australia
Neurogastroenterol Motil 17:31-40. 2005..This review summarizes the current knowledge regarding the control and regulation of SO motility, highlighting laboratory based and clinical research performed over the last 5 years... - Acalculous biliary pain: cholecystectomy alleviates symptoms in patients with abnormal cholescintigraphyL Yap
Department of Surgery, Flinders Medical Centre, Adelaide, South Australia
Gastroenterology 101:786-93. 1991.... - Common duct exploration or endoscopic sphincterotomy for choledocholithiasis?C S Worthley
Department of Surgery, Flinders Medical Centre, Bedford Park, South Australia
Aust N Z J Surg 59:209-15. 1989..In elderly patients with an intact GB, the bile-duct stones can be treated by ES; whether subsequent cholecystectomy is necessary should be assessed on the likelihood of future GB complications... - A novel preparation to study rat pancreatic spinal and vagal mechanosensitive afferents in vitroA C Schloithe
Department of General and Digestive Surgery, Flinders University, Flinders Medical Centre, Adelaide, SA, Australia
Neurogastroenterol Motil 20:1060-9. 2008..Chemosensitive spinal afferent nerve endings are present in the pancreas and respond to a variety of inflammatory and physiological mediators... - Pancreatobiliary afferent recordings in the anaesthetised Australian possumA C Schloithe
Department of General and Digestive Surgery, Centre for Neuroscience, Flinders University, Flinders Medical Centre, Bedford Park, and Department Medicine, Royal Adelaide Hospital, S.A, 5042, Australia
Auton Neurosci 126:292-8. 2006..We conclude that mechanosensitive afferents in the pancreatobiliary system are relatively rare, particularly within the ducts, and/or that they are adapted to monitor stimuli other than luminal distension... - Endoscopic decompression for acute cholangitis due to stonesC S Worthley
Gastrointestinal Surgical Unit, Flinders Medical Centre, Bedford Park, South Australia
Aust N Z J Surg 60:355-9. 1990..This stabilizes the patient's general condition and facilitates subsequent open surgery when required... - Long-term efficacy of a low-pressure adjustable gastric band in the treatment of morbid obesityMohamed Anwar
Department of General and Digestive Surgery, Flinders Medical Center and Adelaide Bariatric Center, South Australia, Australia
Ann Surg 247:771-8. 2008..To determine the long-term efficacy and safety of a low-pressure adjustable gastric band in the treatment for morbid obesity and to detect whether age, gender, or preoperative body mass index (BMI) has an impact on the outcome... - The tripeptide analog feG ameliorates severity of acute pancreatitis in a caerulein mouse modelYusnita Rifai
Dept of Surgery, Centre for Neuroscience, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia
Am J Physiol Gastrointest Liver Physiol 294:G1094-9. 2008..We conclude that feG ameliorates experimental AP acting at least in part by modulating ICAM-1 expression in the pancreas... - Treatment of common bile duct stones discovered during cholecystectomyEdward H Phillips
Department of Surgery, Cedars Sinai Medical Center, 8635 W Third St, Suite 795W, Los Angeles, CA 90048, USA
J Gastrointest Surg 12:624-8. 2008..With all these options available, very few randomized controlled trials (RCTs) have been undertaken. This review analyzes those studies... - Sphincter of Oddi dysfunction: is there a role for medical therapy?Alexander Craig
Gastrointestinal Surgical Unit, Department of Surgery, Flinders Medical Centre, Bedford Park, Adelaide, South Australia, 5042, Australia
Curr Gastroenterol Rep 4:172-6. 2002..The main drawback is that no drugs appear to be specific for the SO, long acting, and free of side effects... - Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitroBilal O Al-Jiffry
Department of General and Digestive Surgery, Centre for Digestive Science, Flinders University of South Australia, Adelaide, Australia
J Gastroenterol Hepatol 17:324-31. 2002..Endothelins are produced by gallbladder epithelial cells, suggesting a role in the regulation of gallbladder function... - Increased gallbladder trypsin in acute cholecystitis indicates functional disorder in the sphincter of oddi and could make EPT a logical procedureJames Toouli
Department of General and Digestive Surgery, Flinders Medical Centre, Adelaide, South Australia, Australia
Surg Laparosc Endosc Percutan Tech 13:314. 2003 - Surgical management of obesity using a soft adjustable gastric bandJustin Greenslade
Department of Surgery, Flinders University, Adelaide, South Australia, Australia
ANZ J Surg 74:195-9. 2004..Weight loss with the SAGB appears durable overall with an acceptable complication rate once an appropriate technique is employed. Consistent life-long follow up is necessary to achieve the best result... - The possum sphincter of Oddi pumps or resists flow depending on common bile duct pressure: a multilumen manometry studyMarlene B Grivell
Department of General and Digestive Surgery, Centre for Digestive Sciences, Flinders Medical Centre, Flinders Drive, Bedford Park, South Australia 5042, Australia
J Physiol 558:611-22. 2004..The pump function promotes TSF at low CBD pressure and prevents bile stasis. At higher CBD pressure, the papilla-SO permits TSF along a pressure gradient, thereby maintaining a low pressure within the biliary tract... - Second-generation recombinant hemoglobin molecules do not stimulate sphincter of Oddi, gallbladder or duodenal motility in the Australian brush-tailed possumShunichi Takahata
Department of General and Digestive Surgery, Centre for Neuroscience and the Centre for Digestive Science, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia
Can J Gastroenterol 18:441-8. 2004.... - Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obestityBilal O Al-Jiffry
Departmentof General and Digestive Surgery, Flinders University of South Australia, Adelaide, Australia
Can J Gastroenterol 17:169-74. 2003..The accompanying reduction in gallbladder emptying, increased gallbladder residual volume and decreased refilling promote gallbladder stasis and hence stone formation... - Effects of bioactive agents on biliary motor functionCharmaine M Woods
Department of General and Digestive Surgery, Flinders University of South Australia, Adelaide, Australia 5042
Curr Gastroenterol Rep 5:154-9. 2003.... - Endothelins induce gallbladder contraction independent of elevated blood pressure in vivo in the Australian possumBilal O Al-Jiffry
Department of General and Digestive Surgery, Centre for Digestive Health, Flinders University of South Australia, Adelaide, Australia
J Gastrointest Surg 6:699-705. 2002..05). Endothelins increase gallbladder motility in vivo, acting directly on the smooth muscle and independent of changes in blood pressure... - Functional gallbladder and sphincter of oddi disordersJose Behar
Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
Gastroenterology 130:1498-509. 2006..The committee recommends that division of the biliary or pancreatic sphincters only be considered when the patient has severe symptoms, meets the required criteria, and other diagnoses are excluded... - Highly selective inhibition of inducible nitric oxide synthase ameliorates experimental acute pancreatitisPer Sandstrom
Department of Biomedicine and Surgery, University Hospital of Linkoping, Linkoping, Sweden
Pancreas 30:e10-5. 2005..The aim of this study was to evaluate treatment with the selective iNOS inhibitors AR-C (AR-C102222AA) and L-NIL (L-N6-(1-iminoethyl)-lysine) in experimental acute pancreatitis... - Characterization of circular muscle motor neurons of the duodenum and distal colon in the Australian brush-tailed possumHiroyuki Konomi
Department of General and Digestive Surgery and the Centre for Neuroscience, Flinders University of South Australia, Adelaide, South Australia 5001, Australia
J Comp Neurol 443:15-26. 2002..These two classes may underlie nonperistaltic motor patterns, which predominate within the duodenum. These findings demonstrate regional differences in the innervation of intestinal circular muscle... - Being CLEAR: evaluation of a module to teach critical appraisal to surgeonsJames Toouli
Department of Surgery, Flinders University, Adelaide, South Australia, Australia
ANZ J Surg 74:69-70. 2004..This paper describes briefly the way in which the module was developed and presents results of participant evaluation of the mature product, which indicate a high level of satisfaction... - Galanin in the regulation of pancreatic vascular perfusionMark E Brooke-Smith
Department of General and Digestive Surgery, Flinders Medical Centre, Flinders University, Bedford Park, South Australia, Australia
Pancreas 36:267-73. 2008..Acute pancreatitis is associated with compromised pancreatic microcirculation. Galanin is a vasoactive neuropeptide, but its role in the regulation of pancreatic vascular perfusion (PVP) is unclear...