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Genomes and Genes | Prue H HartSummaryAffiliation: Flinders University Country: Australia Publications
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Publications
Ultraviolet B-induced suppression of immune responses in interleukin-4-/- mice: relationship to dermal mast cellsP H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, Australia
J Invest Dermatol 114:508-13. 2000..This study further emphasizes the central role of mast cells in the initial processes by which ultraviolet B radiation is immunomodulatory for immune responses to sensitizing antigens applied to nonirradiated sites...- Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in miceP H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University of South Australia, Adelaide, Australia 5001
J Exp Med 187:2045-53. 1998.... - Regulation of the inflammatory response in asthma by mast cell productsP H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, South Australia, Australia
Immunol Cell Biol 79:149-53. 2001..IL-13 is critical to development of allergic asthma, although its mode of action is less clear... - Sunlight, immunosuppression and skin cancer: role of histamine and mast cellsP H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, South Australia, Australia
Clin Exp Pharmacol Physiol 28:1-8. 2001..We propose that mast cells function in humans, as in mice, by initiating immunosuppression and, thereby, allowing a permissive environment for BCC development... - Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytesP H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, Australia
Inflamm Res 49:619-26. 2000..To evaluate potential antiinflammatory properties of tea tree oil, the essential oil steam distilled from the Australian native plant, Melaleuca alternifolia... - Mast cells in UV-B-induced immunosuppressionP H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, Australia
J Photochem Photobiol B 55:81-7. 2000..Histamine may have multiple roles, but experiments with indomethacin administered to mice have shown that one process involves induction of prostanoid production... - A critical role for dermal mast cells in cis-urocanic acid-induced systemic suppression of contact hypersensitivity responses in miceP H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, Australia
Photochem Photobiol 70:807-12. 1999..These studies suggest that mast cells are critical to the processes by which cis-UCA suppresses systemic contact hypersensitivity responses to the hapten, trinitrochlorobenzene, in mice... - Diminished responses to IL-13 by human monocytes differentiated in vitro: role of the IL-13Ralpha1 chain and STAT6P H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University of South Australia, Adelaide, Australia
Eur J Immunol 29:2087-97. 1999..Experiments with a blocking antibody to IL-4R alpha showed that this chain remains an essential component of the IL-13 receptor complex on MDMac... - TNF modulates susceptibility to UVB-induced systemic immunomodulation in mice by effects on dermal mast cell prevalenceP H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University of South Australia, Adelaide, Australia
Eur J Immunol 28:2893-901. 1998..However, it is the mediators released from mast cells upon UVB-induced degranulation, which do not include TNF, that directly signal suppressive events relevant to systemic immunosuppression... - Mast cells, neuropeptides, histamine, and prostaglandins in UV-induced systemic immunosuppressionPrue H Hart
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, Australia
Methods 28:79-89. 2002.... - Nerve growth factor, neuropeptides, and mast cells in ultraviolet-B-induced systemic suppression of contact hypersensitivity responses in miceScott L Townley
Department of Microbiology, School of Medicine and Flinders Medical Research Institute, Flinders University, Adelaide, Australia
J Invest Dermatol 118:396-401. 2002.... - Immunomodulatory constituents of human milk change in response to infant bronchiolitisDani Louise Bryan
Department of Pediatrics and Child Health, Flinders University, South Australia, Australia
Pediatr Allergy Immunol 18:495-502. 2007.... - Increased dermal mast cell prevalence and susceptibility to development of basal cell carcinoma in humansMichele A Grimbaldeston
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, Australia
Methods 28:90-6. 2002..Thus, a high dermal mast cell prevalence as demonstrable in buttock skin is a significant predisposing factor for development of BCC in humans... - IFN-gamma downregulates interleukin-4 functional activity on monocytes by multiple mechanismsClaudine S Bonder
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, South Australia 5001
J Interferon Cytokine Res 22:287-93. 2002..This study characterizes further the opposing effects of the type 1 and type 2 cytokine regulatory systems... - Endogenous interferon-alpha production by differentiating human monocytes regulates expression and function of the IL-2/IL-4 receptor gamma chainClaudine S Bonder
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, Adelaide, GPO Box 2100, Australia 5001
Cytokine 17:187-96. 2002..This study identifies a mechanism for the differential expression of gamma c and varied responses to IL-4 by human monocytes compared with MDMac... - Susceptibility to basal cell carcinoma is associated with high dermal mast cell prevalence in non-sun-exposed skin for an Australian populationsMichele A Grimbaldeston
Department of Microbiology and Infectious Diseases, School of Medicine and Flinders Medical Research Institute, Flinders University, Adelaide, Australia
Photochem Photobiol 78:633-9. 2003..These results show that high prevalence of dermal mast cells in buttock skin but not hand is associated with BCC development in an Australian population... - Centrifugation facilitates transduction of green fluorescent protein in human monocytes and macrophages by adenovirus at low multiplicity of infectionGeorge C Mayne
Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University, GPO Box 2100, Adelaide 5001, Australia
J Immunol Methods 278:45-56. 2003..This methodology should provide significant expression of transgenes in human monocytes and macrophages... - S100A8 induction in keratinocytes by ultraviolet A irradiation is dependent on reactive oxygen intermediatesMichele A Grimbaldeston
Department of Microbiology and Infectious Diseases, School of Medicine and Flinders Medical Research Institute, Flinders University, Adelaide, Australia
J Invest Dermatol 121:1168-74. 2003..These results suggest that UVA-induced S100A8 is expressed by keratinocytes in response to generation of reactive oxygen intermediates... - Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birthMargaret F Annells
Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
Am J Obstet Gynecol 191:2056-67. 2004..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense... - Polyunsaturated fatty acids regulate cytokine and prostaglandin E2 production by respiratory cells in response to mast cell mediatorsDani Louise Bryan
Department of Paediatrics and Child Health, Flinders University, Child Health Research Institute, Adelaide, South Australia, Australia
Lipids 41:1101-7. 2006.... - CD4+ T cells in lymph nodes of UVB-irradiated mice suppress immune responses to new antigens both in vitro and in vivoShelley Gorman
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
J Invest Dermatol 127:915-24. 2007..The potential of these regulatory cells poised to regulate responses to incoming antigens at distant non-irradiated sites broadens the biological impact of UVB irradiation of skin on immunity... - The receptor for cis-urocanic acid remains elusiveEleanor A Woodward
J Invest Dermatol 126:1191-3. 2006 - Mast cells in photodamaged skin: what is their role in skin cancer?Michele A Grimbaldeston
Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, P.O. Box 855, West Perth, Western Australia 6872
Photochem Photobiol Sci 5:177-83. 2006..However, no link was found between dermal mast cell prevalence in hand skin and the presence of basal cell carcinomas. Finally, we discuss other roles for increased numbers of mast cells in UV-exposed photodamaged skin... - Primary defect in UVB-induced systemic immunomodulation does not relate to immature or functionally impaired APCs in regional lymph nodesShelley Gorman
Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth
J Immunol 174:6677-85. 2005.... - Squamous cell carcinoma is not associated with high dermal mast cell prevalence in humansMichele A Grimbaldeston
J Invest Dermatol 119:1204-6. 2002 - Regulation of wheal and flare by tea tree oil: complementary human and rodent studiesZeinab Khalil
National Ageing Research Institute, University of Melbourne, Parkville, Victoria, Australia
J Invest Dermatol 123:683-90. 2004..The underlying strength of these studies is the use of a well-established rat physiologic model to differentiate the mechanism of regulation of microvascular changes by modulatory agents... - Effect of both ultraviolet B irradiation and histamine receptor function on allergic responses to an inhaled antigenJacqueline P McGlade
Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, West Perth, WA, Australia
J Immunol 178:2794-802. 2007.... - Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodesShelley Gorman
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Australia
J Immunol 179:6273-83. 2007..These studies suggest that 1,25(OH)(2)D(3) may be an important mediator by which UVB-irradiation exerts some of its immunomodulatory effects...