Murray Esler

Summary

Country: Australia

Publications

  1. ncbi Neural mechanisms and management of obesity-related hypertension
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Curr Cardiol Rep 10:456-63. 2008
  2. ncbi The 2009 Carl Ludwig Lecture: Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management
    Murray Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Appl Physiol 108:227-37. 2010
  3. ncbi The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension
    Murray Esler
    Baker IDI Heart and Diabetes Institute, Melbourne, Vic, Australia
    Exp Physiol 96:611-22. 2011
  4. ncbi Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road, Central Melbourne, VIC 8008, Australia
    Lancet 376:1903-9. 2010
  5. ncbi Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
  6. ncbi Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor
    Murray Esler
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Stress 10:295-304. 2007
  7. ncbi Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertension 50:862-8. 2007
  8. ncbi Gender differences in sympathetic nervous activity: influence of body mass and blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 25:1411-9. 2007
  9. ncbi Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function
    Nina Eikelis
    Baker Heart Research Institute, Melbourne University, Melbourne, Victoria 8008, Australia
    Am J Physiol Endocrinol Metab 286:E744-52. 2004
  10. ncbi Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 1:103-9. 2008

Detail Information

Publications60

  1. ncbi Neural mechanisms and management of obesity-related hypertension
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Curr Cardiol Rep 10:456-63. 2008
    ..Perhaps more important is the requirement that chosen antihypertensives do not cause weight gain or insulin resistance...
  2. ncbi The 2009 Carl Ludwig Lecture: Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management
    Murray Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Appl Physiol 108:227-37. 2010
    ..With psychogenic heart disease and postural syncope syndromes, knowledge of the neural pathophysiology is emerging, but clinical translation remains for the future...
  3. ncbi The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension
    Murray Esler
    Baker IDI Heart and Diabetes Institute, Melbourne, Vic, Australia
    Exp Physiol 96:611-22. 2011
    ....
  4. ncbi Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
    Murray D Esler
    Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road, Central Melbourne, VIC 8008, Australia
    Lancet 376:1903-9. 2010
    ..We aimed to assess effectiveness and safety of catheter-based renal denervation for reduction of blood pressure in patients with treatment-resistant hypertension...
  5. ncbi Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
    ....
  6. ncbi Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor
    Murray Esler
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Stress 10:295-304. 2007
    ....
  7. ncbi Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertension 50:862-8. 2007
    ..The underlying central nervous system mechanism and the adverse consequences of the 2 modes of sympathetic activation may differ...
  8. ncbi Gender differences in sympathetic nervous activity: influence of body mass and blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 25:1411-9. 2007
    ..We tested whether the sympathetic nervous system was differently affected in men and women by the body mass index (BMI), BP, leptin and weight loss...
  9. ncbi Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function
    Nina Eikelis
    Baker Heart Research Institute, Melbourne University, Melbourne, Victoria 8008, Australia
    Am J Physiol Endocrinol Metab 286:E744-52. 2004
    ..9 +/- 1.4 vs. 5.3 +/- 2.2 ng/min (P = 0.042). These results suggest that leptin is released within the brain and at an increased rate in obese humans, in whom activation of brain serotonergic and NPY mechanisms also exists...
  10. ncbi Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 1:103-9. 2008
    ..Clinical observations in patients with postural tachycardia syndrome (POTS) suggest abnormal sympathetic nervous system activity and a dysfunction of the norepinephrine (NE) transporter (NET)...
  11. ncbi Chronic mental stress is a cause of essential hypertension: presence of biological markers of stress
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:498-502. 2008
    ..This judgement was reached after consideration of the epidemiological evidence, but in particular after review of the specific elements of the neural pathophysiology of essential hypertension, described above...
  12. ncbi Recurrent postural vasovagal syncope: sympathetic nervous system phenotypes
    Gautam Vaddadi
    Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 4:711-8. 2011
    ..We investigated neural circulatory control in these 2 phenotypes...
  13. ncbi Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 56:351-8. 2010
    ..Sympathetic activity is closely associated with cardiovascular and renal alterations observed in these subjects...
  14. ncbi Interactions between leptin and the human sympathetic nervous system
    Nina Eikelis
    Baker Heart Research Institute and Alfred Baker Medical Unit, Alfred Hospital, Melbourne, Australia
    Hypertension 41:1072-9. 2003
    ....
  15. ncbi The neuronal noradrenaline transporter, anxiety and cardiovascular disease
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    J Psychopharmacol 20:60-6. 2006
    ....
  16. ncbi Effect of angiotensin II receptor blockade on autonomic nervous system function in patients with essential hypertension
    Henry Krum
    National Health and Medical Research Council of Australia, Centre of Clinical Research Excellence in Therapeutics, Monash University, Melbourne, VIC 3004, Australia
    Am J Physiol Heart Circ Physiol 290:H1706-12. 2006
    ..We conclude that sympathetic nervous inhibition is not a major component of the blood pressure-lowering action of ARBs in essential hypertension...
  17. ncbi Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 58:43-50. 2011
    ..These responses may represent a combination of peripheral (baroreflex-mediated) and central effects of ghrelin...
  18. ncbi Association between the sympathetic firing pattern and anxiety level in patients with the metabolic syndrome and elevated blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    J Hypertens 28:543-50. 2010
    ....
  19. ncbi Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 22:1529-34. 2004
    ..Acute sympathetic nervous activation is a proven trigger for adverse cardiovascular events. Accordingly, antihypertensive drugs inhibiting sympathetic outflow represent a theoretically attractive therapeutic option...
  20. ncbi Sympathetic neuronal regulation of the heart in aging and heart failure
    David Kaye
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, VIC 8008, Australia
    Cardiovasc Res 66:256-64. 2005
    ..Our conclusion is, on balance, that this proposition is not supported by the available evidence...
  21. ncbi Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
    Henry Krum
    Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic, Australia
    Lancet 373:1275-81. 2009
    ....
  22. ncbi NPY and NPY Y1 receptor effects on noradrenaline overflow from the rat brain in vitro
    Jacqueline A Hastings
    Baker Heart Research Institute, Human Neurotransmitter Laboratory, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Regul Pept 120:107-12. 2004
    ....
  23. ncbi Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress
    Murray Esler
    Baker Medical Research Institute, Melbourne, Australia
    Biogerontology 3:45-9. 2002
    ..Sympathetic nervous responses with stressors were augmented. Conversely, adrenal medullary release of epinephrine was subnormal in the elderly, at rest and during stress...
  24. ncbi Single-unit sympathetic discharge pattern in pathological conditions associated with elevated cardiovascular risk
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:503-7. 2008
    ..4. Single-unit methodology may represent a major step forward in the understanding of the link between disturbed sympathetic nerve firing and associated cardiovascular risk...
  25. ncbi Mechanisms of sympathetic activation in obesity-related hypertension
    Murray Esler
    Baker Heart Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Hypertension 48:787-96. 2006
  26. ncbi The neurobiology of human obesity
    Nina Eikelis
    Baker Heart Research Institute, Melbourne, Australia
    Exp Physiol 90:673-82. 2005
    ..Brain leptin release has the potential to override the peripheral, adipocyte leptin system...
  27. ncbi Cardiac sympathetic nerve biology and brain monoamine turnover in panic disorder
    Murray Esler
    Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Ann N Y Acad Sci 1018:505-14. 2004
    ....
  28. ncbi Effects of dietary weight loss on sympathetic activity and cardiac risk factors associated with the metabolic syndrome
    Nora E Straznicky
    Cardiovascular Nutrition Laboratory, Wynn Domain, Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 90:5998-6005. 2005
    ....
  29. ncbi Single-unit analysis of sympathetic nervous discharges in patients with panic disorder
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria, Australia
    J Physiol 570:637-43. 2006
    ..Quantification from single vasoconstrictor unit recording provides evidence of a disturbed sympathetic firing pattern in patients with panic disorder...
  30. ncbi Management of hypertension complicated by psychiatric comorbidity
    Murray Esler
    Baker Heart Research Institute, Royal Women's Hospital, Melbourne, Australia
    J Clin Hypertens (Greenwich) 9:708-13. 2007
  31. ncbi The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover
    Murray Esler
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Am J Physiol Regul Integr Comp Physiol 282:R909-16. 2002
    ....
  32. ncbi Differentiation in the effects of the angiotensin II receptor blocker class on autonomic function
    Murray Esler
    Baker Medical Research Institute, Commercial Road, Prahran 3181, Melbourne, Australia
    J Hypertens Suppl 20:S13-9. 2002
    ..A reduction in noradrenaline spillover disproportionate to any possible fall in nerve firing would document the presence of presynaptic antagonism of noradrenaline release...
  33. ncbi Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:1126-32. 2009
    ..The purpose of this study was to examine the effects of weight loss on sympathetic nervous system responsiveness to glucose ingestion in obese subjects with metabolic syndrome, in whom such responses are reportedly blunted...
  34. ncbi The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components
    Nora E Straznicky
    Laboratories of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 96:E503-8. 2011
    ..Sympathetic nervous system (SNS) overactivity participates in both the pathogenesis and adverse clinical complications of metabolic syndrome (MetS) obesity...
  35. ncbi New therapeutic approaches to resistant hypertension
    Markus P Schlaich
    Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria, 8008, Australia
    Curr Hypertens Rep 12:296-302. 2010
    ..In this context, several lines of research have generated promising results based on both novel pharmacologic and device-based approaches that may more effectively treat resistant hypertension and its adverse consequences in the future...
  36. ncbi The role of sympathetic nervous activity in renal injury and end-stage renal disease
    Kazuko Masuo
    Nucleus Network Ltd, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Hypertens Res 33:521-8. 2010
    ..These insights may be useful to improve prevention and treatment of renal injury in these patients...
  37. ncbi Persistence of muscle sympathetic nerve activity during vasovagal syncope
    Gautam Vaddadi
    Human Neurotransmitter Laboratory, BakerIDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia
    Eur Heart J 31:2027-33. 2010
    ..To determine whether sympathetic nerve firing to skeletal muscle vasculature is withdrawn during vasovagal syncope (VVS) precipitated by passive graded head-up tilt (HUT) table testing...
  38. ncbi Cardiovascular and renal complications of type 2 diabetes in obesity: role of sympathetic nerve activity and insulin resistance
    Kazuko Masuo
    Nucleus Network Ltd, Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria 3004, Australia
    Curr Diabetes Rev 6:58-67. 2010
    ..Further, to clarify the pathogenesis and mechanisms of the association between obesity, diabetes, and hypertension may lead to reductions in cardiovascular and renal risk...
  39. ncbi Blunted sympathetic neural response to oral glucose in obese subjects with the insulin-resistant metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters and Heart Failure Division, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Am J Clin Nutr 89:27-36. 2009
    ..Glucose ingestion stimulates sympathetic nervous system (SNS) activity in lean subjects, whereas blunted responses have been reported in the obese...
  40. ncbi Mediators of sympathetic activation in metabolic syndrome obesity
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    Curr Hypertens Rep 10:440-7. 2008
    ..Because chronic sympathetic activation contributes to hypertension and its target-organ damage, sympathoinhibition remains an important goal in the therapeutic management of the metabolic syndrome...
  41. ncbi Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population
    Kazuko Masuo
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 31:1093-100. 2008
    ..We therefore hypothesize that leptin-receptor play a role in the development of obesity through leptin resistance and blunted leptin-mediated sympathetic nerve activity...
  42. ncbi Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 59:71-9. 2010
    ..This study was conducted to examine the effects of lifestyle interventions (weight loss alone or together with exercise) on SNS function...
  43. ncbi Sympathetic and cardiac baroreflex function in panic disorder
    Elisabeth A Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Hypertens 20:2445-51. 2002
    ..The cause is not known, but possibly involves sympathetic nervous activation. In this study, we evaluated the arterial baroreflex control of vascular sympathetic nervous outflow and cardiac baroreflex function in panic disorder patients...
  44. ncbi Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy
    Markus P Schlaich
    Human Neurotransmitter Laboratory, Baker Heart Research Institute and Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria 8008, Australia
    Circulation 108:560-5. 2003
    ..Sympathetic activation has been suggested to contribute to LV hypertrophy, but this has not yet been conclusively validated in humans...
  45. ncbi Peripheral chemoreflex activation contributes to sympathetic baroreflex impairment in chronic heart failure
    Fabien Despas
    Institut National de la Sante et de la Recherche Medicale, UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
    J Hypertens 30:753-60. 2012
    ..Chemoreflex-mediated sympathetic activation contributes to both initiation and progression of chronic heart failure (CHF)...
  46. ncbi Influence of leptin on neurotransmitter overflow from the rat brain in vitro
    Jacqueline A Hastings
    Baker Medical Research Institute, Human Neurotransmitter Laboratory, P O Box 6492, Victoria 8008, Melbourne, Australia
    Regul Pept 103:67-74. 2002
    ..This study lends support to the notion of a complex interaction of the leptinergic and brain neurotransmitters involved in the control of feeding and energy metabolism...
  47. ncbi Specific serotonin reuptake inhibition in major depressive disorder adversely affects novel markers of cardiac risk
    Tye Dawood
    Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 30:285-93. 2007
    ..Mechanisms potentially responsible for generating cardiac risk in patients treated with selective serotonin reuptake inhibitors may need to be therapeutically targeted to reduce the incidence of coronary heart disease in this population...
  48. ncbi Regional sympathetic effects of low-dose clonidine in heart failure
    Anuradha Aggarwal
    Baker Medical Research Institute, University of Melbourne, Melbourne, Victoria, Australia
    Hypertension 41:553-7. 2003
    ..In addition to the beneficial effects of antiadrenergic therapy in the heart, the renal sympatholytic effect may counter the salt and water retention that is a hallmark of the condition...
  49. ncbi Raised sympathetic nerve activity in heart failure and central sleep apnea is due to heart failure severity
    Darren Mansfield
    Department of Respiratory Medicine and Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Circulation 107:1396-400. 2003
    ..CONCLUSION: Total body and cardiac sympathetic nerve activity are elevated in CHF-CSA compared with CHF-OSA and CHF-N patients and are related to heart failure not apnea severity...
  50. ncbi Acute electrophysiologic effects of intravenous amiodarone are independent of a sympatholytic action in humans
    Deepak Haikerwal
    Baker Heart Research Institute, Melbourne, Australia
    J Cardiovasc Pharmacol 41:760-5. 2003
    ..Acute IV AM did not exert a sympatholytic action in humans, with no attenuation in hemodynamic or NA response to handgrip or increase in DHPG production, despite producing an electrophysiologic response...
  51. ncbi Autonomic control of the aging heart
    David M Kaye
    Heart Failure Research Group, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne VIC 8008, Australia
    Neuromolecular Med 10:179-86. 2008
    ..Attention to the mechanisms of these changes and the development of appropriate therapies may serve to reduce the added influence of age on outcome in patients experiencing cardiovascular disease...
  52. ncbi Chronic atrial fibrillation does not influence the magnitude of sympathetic overactivity in patients with heart failure
    Paul A Gould
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Eur Heart J 24:1657-62. 2003
    ..2+/-0.1 vs 1.6+/-0.1l/min, P<0.05). CONCLUSION: Congestive heart failure patients in AF do not appear to have heightened sympathetic tone compared to CHF patients in SR...
  53. ncbi Beta-adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure
    David M Kaye
    Heart Centre, Alfred Hospital and Baker Medical Reserach Insititute, Melbourne, Victoria, Australia
    Pharmacogenetics 13:379-82. 2003
    ..These data demonstrate a significant influence of beta2AR genotype in the response to carvedilol in CHF patients. Accordingly, determination of beta2AR status may be of value in the tailoring of individual therapy in patients with CHF...
  54. ncbi Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy
    David A Barton
    Department of Psychological Medicine, Alfred Hospital, Monash University, Melbourne, Victoria, Australia
    Arch Gen Psychiatry 65:38-46. 2008
    ..The biological basis for the development of major depressive disorder (MDD) remains incompletely understood...
  55. ncbi Oestrogen supplementation attenuates responses to psychological stress in elderly men rendered hypogonadal after treatment for prostate cancer
    Paul A Komesaroff
    Hormone and Vasculature Laboratory and Alfred and Baker Medical Center, Baker Medical Research Institute and Alfred Hospital, Melbourne, Victoria, Australia
    Clin Endocrinol (Oxf) 56:745-53. 2002
    ....
  56. ncbi Norepinephrine turnover is increased in suprabulbar subcortical brain regions and is related to whole-body sympathetic activity in human heart failure
    Anuradha Aggarwal
    Baker Medical Research Institute, Melbourne, Australia
    Circulation 105:1031-3. 2002
    ..The findings suggest that the activation of noradrenergic neurons projecting rostrally from the brain stem mediates sympathetic nervous stimulation in CHF...
  57. ncbi Atrial fibrillation is associated with decreased cardiac sympathetic response to isometric exercise in CHF in comparison to sinus rhythm
    Paul A Gould
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne, Australia
    Pacing Clin Electrophysiol 31:1125-9. 2008
    ..In previous studies, we have demonstrated cardiac baroreceptor abnormalities in association with AF and CHF. In this study, we sought to examine the effect of cardiac rhythm on the cardiac sympathetic response to exercise in CHF...
  58. ncbi Atrial fibrillation impairs cardiac sympathetic response to baroreceptor unloading in congestive heart failure
    Paul A Gould
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne VIC 8008, Australia
    Eur Heart J 26:2562-7. 2005
    ..025). CONCLUSION: AF is associated with impaired cardiac sympathetic response to baroreceptor unloading compared with SR in CHF, possibly secondary to atrial fibrosis...
  59. ncbi Divergent effects of ANP and BNP in acute heart failure: evidence for a putative BNP-selective receptor?
    Hans Peter Brunner-La Rocca
    Baker Medical Research Institute, Melbourne, Australia
    J Hypertens 20:1195-201. 2002
    ..Our aim was to compare the haemodynamic actions of ANP with BNP, using a classical vasodilator as the control, in greyhound dogs with acute pacing-induced HF...