Raymond Murray Dawson

Summary

Affiliation: Defence Science and Technology Organisation
Country: Australia

Publications

  1. ncbi Characterization of the Asialofetuin microtitre plate-binding assay for evaluating inhibitors of ricin lectin activity
    R M Dawson
    Aeronautical and Maritime Research Laboratory, Defence Science and Technology Organization, Melbourne, Victoria, Australia
    J Appl Toxicol 19:307-12. 1999
  2. ncbi Characterization of the binding of cholera toxin to ganglioside GM1 immobilized onto microtitre plates
    R M Dawson
    Platforms Sciences Laboratory, Defence Science and Technology Organization, PO Box 4331, Melbourne, Victoria 3001, Australia
    J Appl Toxicol 25:30-8. 2005
  3. ncbi Monovalent and polyvalent carbohydrate inhibitors of ricin binding to a model of the cell-surface receptor
    R M Dawson
    Platforms Sciences Laboratory, Defence Science and Technology Organisation, Melbourne VIC 3001, Australia
    J Appl Toxicol 26:247-52. 2006
  4. ncbi Degradation of nerve agents by an organophosphate-degrading agent (OpdA)
    R M Dawson
    DSTO Melbourne, Melbourne, Vic, Australia
    J Hazard Mater 157:308-14. 2008
  5. ncbi Properties and applications of antimicrobial peptides in biodefense against biological warfare threat agents
    Raymond Murray Dawson
    DSTO Defense Science and Technology Organisation, Melbourne, Australia
    Crit Rev Microbiol 34:89-107. 2008
  6. ncbi The CMG2 ELISA for evaluating inhibitors of the binding of anthrax toxin protective antigen to its receptor
    Raymond M Dawson
    DSTO Melbourne, Defence Science and Technology Organisation, Melbourne, Vic, Australia
    J Pharmacol Toxicol Methods 59:50-5. 2009
  7. ncbi Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis
    Raymond M Dawson
    DSTO Melbourne, PO Box 4331, Melbourne, VIC 3001, Australia
    Int J Antimicrob Agents 36:359-63. 2010
  8. ncbi Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity
    Raymond M Dawson
    DSTO Melbourne, 506 Lorimer Street, Fishermans Bend, VIC 3207, Australia
    Int J Antimicrob Agents 37:432-7. 2011
  9. ncbi Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes
    Raymond M Dawson
    Human Protection and Performance Division, Defence Science and Technology Organisation, 506 Lorimer Street, Fishermans Bend, VIC 3207, Australia
    Int J Antimicrob Agents 38:237-42. 2011

Detail Information

Publications9

  1. ncbi Characterization of the Asialofetuin microtitre plate-binding assay for evaluating inhibitors of ricin lectin activity
    R M Dawson
    Aeronautical and Maritime Research Laboratory, Defence Science and Technology Organization, Melbourne, Victoria, Australia
    J Appl Toxicol 19:307-12. 1999
    ..The assay permits qualitative comparison of inhibitors of ricin B-chain lectin activity...
  2. ncbi Characterization of the binding of cholera toxin to ganglioside GM1 immobilized onto microtitre plates
    R M Dawson
    Platforms Sciences Laboratory, Defence Science and Technology Organization, PO Box 4331, Melbourne, Victoria 3001, Australia
    J Appl Toxicol 25:30-8. 2005
    ..Data from the literature support the very slow dissociation rates of the toxin-GM1 complex...
  3. ncbi Monovalent and polyvalent carbohydrate inhibitors of ricin binding to a model of the cell-surface receptor
    R M Dawson
    Platforms Sciences Laboratory, Defence Science and Technology Organisation, Melbourne VIC 3001, Australia
    J Appl Toxicol 26:247-52. 2006
    ..Encouraging results, however, were obtained with a self-assembled lyotropic mesophase gel containing novel synthetic galactose-based surfactants, which was able to sequester ricin from aqueous solution in a 2-phase system...
  4. ncbi Degradation of nerve agents by an organophosphate-degrading agent (OpdA)
    R M Dawson
    DSTO Melbourne, Melbourne, Vic, Australia
    J Hazard Mater 157:308-14. 2008
    ..The value was within an order of magnitude for the highest value reported for sarin, but there appears to be no published value for ethyl sarin for comparison. The OpdA enzymes were relatively inefficient in degrading soman...
  5. ncbi Properties and applications of antimicrobial peptides in biodefense against biological warfare threat agents
    Raymond Murray Dawson
    DSTO Defense Science and Technology Organisation, Melbourne, Australia
    Crit Rev Microbiol 34:89-107. 2008
    ..Synthesis of these peptides in multivalent form leads to a synergistic increase in antibacterial activity. Strategies to enhance the potency, stability, and selectivity of AMPs are discussed...
  6. ncbi The CMG2 ELISA for evaluating inhibitors of the binding of anthrax toxin protective antigen to its receptor
    Raymond M Dawson
    DSTO Melbourne, Defence Science and Technology Organisation, Melbourne, Vic, Australia
    J Pharmacol Toxicol Methods 59:50-5. 2009
    ..To study the interaction between the PA and its receptor, and inhibition of the binding, an enzyme-linked immunosorbent assay (ELISA) was developed...
  7. ncbi Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis
    Raymond M Dawson
    DSTO Melbourne, PO Box 4331, Melbourne, VIC 3001, Australia
    Int J Antimicrob Agents 36:359-63. 2010
    ..Nevertheless, strategies to reduce toxicity whilst maintaining high antimicrobial activity are worth pursuing in light of the results obtained...
  8. ncbi Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity
    Raymond M Dawson
    DSTO Melbourne, 506 Lorimer Street, Fishermans Bend, VIC 3207, Australia
    Int J Antimicrob Agents 37:432-7. 2011
    ..Two of the designed analogues had comparable antibacterial efficacy with SMAP-29 against B. anthracis but reduced haemolytic activity and therefore had a therapeutic index that was enhanced 2.3-2.6-fold over that of SMAP-29...
  9. ncbi Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes
    Raymond M Dawson
    Human Protection and Performance Division, Defence Science and Technology Organisation, 506 Lorimer Street, Fishermans Bend, VIC 3207, Australia
    Int J Antimicrob Agents 38:237-42. 2011
    ..globigii has often been used as a non-pathogenic simulant for B. anthracis, in this study it was found that the sensitivity of B. globigii to peptides was not a reliable predictor of the sensitivity of B. anthracis to the same peptides...