Gavin Lambert

Summary

Affiliation: Baker Heart Research Institute
Country: Australia

Publications

  1. ncbi Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus
    Gavin Lambert
    Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenbourg, Sweden
    Brain Res Bull 58:77-82. 2002
  2. ncbi Acute response to intracisternal bupivacaine in patients with refractory pain of the head and neck
    Gavin Lambert
    Department of Clinical Physiology, Sahlgrenska Hospital, Goteborg, Sweden
    J Physiol 570:421-8. 2006
  3. ncbi Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?
    David A Barton
    Human Neurotransmitter Laboratory, Australia
    J Hypertens 25:2117-24. 2007
  4. ncbi Increased suicide rate in the middle-aged and its association with hours of sunlight
    Gavin Lambert
    Human Neurotransmitter Laboratory, Baker Medical Research Institute, Australia
    Am J Psychiatry 160:793-5. 2003
  5. ncbi Effect of sunlight and season on serotonin turnover in the brain
    G W Lambert
    Human Neurotransmitter Laboratory and Alfred and Baker Medical Unit, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Victoria 8008, Melbourne, Australia
    Lancet 360:1840-2. 2002
  6. ncbi Paring down on Descartes: a review of brain noradrenaline and sympathetic nervous function
    G W Lambert
    Human Neurotransmitter Laboratory, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 28:979-82. 2001
  7. ncbi Subarachnoid haemorrhage-induced sympathoexcitation in rats is reversed by bosentan or sodium nitroprusside
    G Lambert
    Laboratoire de Pharmacologie, CNRS UMR 8604, Faculte de Medecine Necker, Paris, France
    Clin Exp Pharmacol Physiol 28:200-5. 2001
  8. ncbi Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
  9. ncbi Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor
    Murray Esler
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Stress 10:295-304. 2007
  10. ncbi Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 1:103-9. 2008

Collaborators

Detail Information

Publications52

  1. ncbi Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus
    Gavin Lambert
    Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenbourg, Sweden
    Brain Res Bull 58:77-82. 2002
    ..The diminished cerebral perfusion seen following subarachnoid bleeding may occur as a result of activation of central catecholaminergic neurones...
  2. ncbi Acute response to intracisternal bupivacaine in patients with refractory pain of the head and neck
    Gavin Lambert
    Department of Clinical Physiology, Sahlgrenska Hospital, Goteborg, Sweden
    J Physiol 570:421-8. 2006
    ..Although these effects are transient, they warrant caution at the induction of intracisternal local anaesthesia...
  3. ncbi Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?
    David A Barton
    Human Neurotransmitter Laboratory, Australia
    J Hypertens 25:2117-24. 2007
    ..Evidence exists linking major depressive disorder (MDD) with clinical cardiovascular events. The importance of the sympathetic nervous system in the generation of cardiac risk in other contexts is established...
  4. ncbi Increased suicide rate in the middle-aged and its association with hours of sunlight
    Gavin Lambert
    Human Neurotransmitter Laboratory, Baker Medical Research Institute, Australia
    Am J Psychiatry 160:793-5. 2003
    ....
  5. ncbi Effect of sunlight and season on serotonin turnover in the brain
    G W Lambert
    Human Neurotransmitter Laboratory and Alfred and Baker Medical Unit, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Victoria 8008, Melbourne, Australia
    Lancet 360:1840-2. 2002
    ..294, p=0.010), and rose rapidly with increased luminosity. Our findings are further evidence for the notion that changes in release of serotonin by the brain underlie mood seasonality and seasonal affective disorder...
  6. ncbi Paring down on Descartes: a review of brain noradrenaline and sympathetic nervous function
    G W Lambert
    Human Neurotransmitter Laboratory, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 28:979-82. 2001
    ....
  7. ncbi Subarachnoid haemorrhage-induced sympathoexcitation in rats is reversed by bosentan or sodium nitroprusside
    G Lambert
    Laboratoire de Pharmacologie, CNRS UMR 8604, Faculte de Medecine Necker, Paris, France
    Clin Exp Pharmacol Physiol 28:200-5. 2001
    ..4. Our results indicate that subarachnoid haemorrhage is associated with an acute activation of the sympathetic nervous system. The degree of sympathoexcitation can be reversed by the use of either bosentan or SNP...
  8. ncbi Human sympathetic nerve biology: parallel influences of stress and epigenetics in essential hypertension and panic disorder
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    Ann N Y Acad Sci 1148:338-48. 2008
    ....
  9. ncbi Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor
    Murray Esler
    Baker Heart Research Institute, Melbourne, Vic, Australia
    Stress 10:295-304. 2007
    ....
  10. ncbi Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndrome
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 1:103-9. 2008
    ..Clinical observations in patients with postural tachycardia syndrome (POTS) suggest abnormal sympathetic nervous system activity and a dysfunction of the norepinephrine (NE) transporter (NET)...
  11. ncbi Gender differences in sympathetic nervous activity: influence of body mass and blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 25:1411-9. 2007
    ..We tested whether the sympathetic nervous system was differently affected in men and women by the body mass index (BMI), BP, leptin and weight loss...
  12. ncbi Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Hypertension 50:862-8. 2007
    ..The underlying central nervous system mechanism and the adverse consequences of the 2 modes of sympathetic activation may differ...
  13. ncbi Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function
    Nina Eikelis
    Baker Heart Research Institute, Melbourne University, Melbourne, Victoria 8008, Australia
    Am J Physiol Endocrinol Metab 286:E744-52. 2004
    ..9 +/- 1.4 vs. 5.3 +/- 2.2 ng/min (P = 0.042). These results suggest that leptin is released within the brain and at an increased rate in obese humans, in whom activation of brain serotonergic and NPY mechanisms also exists...
  14. ncbi Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 56:351-8. 2010
    ..Sympathetic activity is closely associated with cardiovascular and renal alterations observed in these subjects...
  15. ncbi Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans
    David A Mitchell
    Human Neurotransmitter Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    J Physiol 587:2589-97. 2009
    ..We suggest that measurements of transcranial plasma noradrenaline spillover have utility as a method for assessing the sympathetic nerve activity of the cerebral vasculature...
  16. ncbi Chronic mental stress is a cause of essential hypertension: presence of biological markers of stress
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:498-502. 2008
    ..This judgement was reached after consideration of the epidemiological evidence, but in particular after review of the specific elements of the neural pathophysiology of essential hypertension, described above...
  17. ncbi Decreased renal sympathetic activity in response to cardiac unloading with nitroglycerin in patients with heart failure
    Magnus Petersson
    Department of Cardiology, The Cardiovascular Institute, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Eur J Heart Fail 7:1003-10. 2005
    ..To examine changes in renal sympathetic outflow in response to cardiac unloading with nitroglycerin (GTN) in patients with chronic heart failure (CHF) and healthy subjects (HS)...
  18. ncbi Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Hypertension 58:43-50. 2011
    ..These responses may represent a combination of peripheral (baroreflex-mediated) and central effects of ghrelin...
  19. ncbi Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion
    Murray Esler
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    J Hypertens 22:1529-34. 2004
    ..Acute sympathetic nervous activation is a proven trigger for adverse cardiovascular events. Accordingly, antihypertensive drugs inhibiting sympathetic outflow represent a theoretically attractive therapeutic option...
  20. ncbi Recurrent postural vasovagal syncope: sympathetic nervous system phenotypes
    Gautam Vaddadi
    Human Neurotransmitter Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Circ Arrhythm Electrophysiol 4:711-8. 2011
    ..We investigated neural circulatory control in these 2 phenotypes...
  21. ncbi The neuronal noradrenaline transporter, anxiety and cardiovascular disease
    Murray Esler
    Baker Heart Research Institute, Melbourne, Australia
    J Psychopharmacol 20:60-6. 2006
    ....
  22. ncbi Increased cardiac sympathetic drive in renovascular hypertension
    Magnus J Petersson
    Department of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden
    J Hypertens 20:1181-7. 2002
    ..Patients with renovascular hypertension (RVH) have high cardiovascular mortality and morbidity. In these patients, overall sympathetic nerve activity is increased. It is unknown, however, whether this increase also involves the heart...
  23. ncbi Association between the sympathetic firing pattern and anxiety level in patients with the metabolic syndrome and elevated blood pressure
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    J Hypertens 28:543-50. 2010
    ....
  24. ncbi Regional sympathetic effects of low-dose clonidine in heart failure
    Anuradha Aggarwal
    Baker Medical Research Institute, University of Melbourne, Melbourne, Victoria, Australia
    Hypertension 41:553-7. 2003
    ..In addition to the beneficial effects of antiadrenergic therapy in the heart, the renal sympatholytic effect may counter the salt and water retention that is a hallmark of the condition...
  25. ncbi Cardiac sympathetic nerve biology and brain monoamine turnover in panic disorder
    Murray Esler
    Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Ann N Y Acad Sci 1018:505-14. 2004
    ....
  26. ncbi Single-unit sympathetic discharge pattern in pathological conditions associated with elevated cardiovascular risk
    Elisabeth Lambert
    Human Neurotransmitters Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 35:503-7. 2008
    ..4. Single-unit methodology may represent a major step forward in the understanding of the link between disturbed sympathetic nerve firing and associated cardiovascular risk...
  27. ncbi Single-unit analysis of sympathetic nervous discharges in patients with panic disorder
    Elisabeth Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria, Australia
    J Physiol 570:637-43. 2006
    ..Quantification from single vasoconstrictor unit recording provides evidence of a disturbed sympathetic firing pattern in patients with panic disorder...
  28. ncbi NPY and NPY Y1 receptor effects on noradrenaline overflow from the rat brain in vitro
    Jacqueline A Hastings
    Baker Heart Research Institute, Human Neurotransmitter Laboratory, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Regul Pept 120:107-12. 2004
    ....
  29. ncbi Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure
    Magnus Petersson
    Department of Cardiology, The Cardiovascular Institute, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Eur Heart J 26:906-13. 2005
    ..We assessed the hypothesis that renal noradrenaline (NA) spillover is a predictor of the combined endpoint of all-cause mortality and heart transplantation in CHF...
  30. ncbi Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress
    Murray Esler
    Baker Medical Research Institute, Melbourne, Australia
    Biogerontology 3:45-9. 2002
    ..Sympathetic nervous responses with stressors were augmented. Conversely, adrenal medullary release of epinephrine was subnormal in the elderly, at rest and during stress...
  31. ncbi The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover
    Murray Esler
    Baker Medical Research Institute, Melbourne, Victoria 8008, Australia
    Am J Physiol Regul Integr Comp Physiol 282:R909-16. 2002
    ....
  32. ncbi Mechanisms of sympathetic activation in obesity-related hypertension
    Murray Esler
    Baker Heart Research Institute, PO Box 6492 St Kilda Rd Central, Melbourne, Victoria 8008, Australia
    Hypertension 48:787-96. 2006
  33. ncbi Preserved left ventricular structure and function in mice with cardiac sympathetic hyperinnervation
    Helen Kiriazis
    Experimental Cardiology Laboratory, Baker Heart Research Institute, P O Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Am J Physiol Heart Circ Physiol 289:H1359-65. 2005
    ..In conclusion, overexpression of NGF in heart leads to sympathetic hyperinnervation that is not associated with detrimental effects on LV performance and is likely due to concomitantly enhanced norepinephrine neuronal uptake...
  34. ncbi Regional norepinephrine spillover in response to angiotensin-converting enzyme inhibition in healthy subjects
    Mats Johansson
    Department of Clinical Physiology, Cardiovascular Institute, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    J Hypertens 21:1371-5. 2003
    ..The aim of the present study was to investigate overall, cardiac and renal sympathetic nerve activity, before and after intravenous enalaprilat, in healthy normotensive subjects without an activated RAS...
  35. ncbi Psychophysiological mechanisms in panic disorder: a correlative analysis of noradrenaline spillover, neuronal noradrenaline reuptake, power spectral analysis of heart rate variability, and psychological variables
    Marlies E Alvarenga
    Faculty of Medicine, Monash University and Cardiovascular Neurosciences Division, Baker Heart Research Institute, Baker Heart Research Institute, Prahran, Victoria, Australia
    Psychosom Med 68:8-16. 2006
    ..We estimated cardiac vagal activity from heart rate variability (HRV) measurements and quantified sympathetic nervous system (SNS) activity using plasma noradrenaline tracer kinetics methodology...
  36. ncbi Renal denervation: a potential new treatment modality for polycystic ovary syndrome?
    Markus P Schlaich
    Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Hypertens 29:991-6. 2011
    ..Here we report on the effects of renal denervation on hemodynamic, metabolic, and renal parameters in two obese PCOS patients with hypertension...
  37. ncbi Autonomic control of the heart and renal vascular bed during autonomic dysreflexia in high spinal cord injury
    Sinsia A Gao
    Department of Clinical Physiology, Sahlgrenska University Hospital, 41345 Goteborg, Sweden
    Clin Auton Res 12:457-64. 2002
    ..This activation was counterbalanced by an increased vagal activity as evidenced by reduction of the heart rate...
  38. ncbi Cerebral noradrenaline spillover and its relation to muscle sympathetic nervous activity in healthy human subjects
    G W Lambert
    Human Autonomic Function Laboratory, Baker Medical Research Institute, Prahran, Vic, Australia
    J Auton Nerv Syst 64:57-64. 1997
    ....
  39. ncbi Cardiac response to norepinephrine and sympathetic nerve stimulation following experimental subarachnoid hemorrhage
    Elisabeth Lambert
    Human Neurotransmitter, Baker Medical Research Institute, Melbourne, Victoria, Australia
    J Neurol Sci 198:43-50. 2002
    ..However, hypersensitivity of the heart may not be explained by changes in norepinephrine release or by beta-receptor density...
  40. ncbi Influence of leptin on neurotransmitter overflow from the rat brain in vitro
    Jacqueline A Hastings
    Baker Medical Research Institute, Human Neurotransmitter Laboratory, P O Box 6492, Victoria 8008, Melbourne, Australia
    Regul Pept 103:67-74. 2002
    ..This study lends support to the notion of a complex interaction of the leptinergic and brain neurotransmitters involved in the control of feeding and energy metabolism...
  41. ncbi Reduced spontaneous baroreceptor sensitivity in patients with renovascular hypertension
    Sinsia A Gao
    Department of Clinical Physiology, Goteborg University, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    J Hypertens 20:111-6. 2002
    ....
  42. ncbi Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and Angiotensin neuromodulation
    Markus P Schlaich
    Department of Medicine IV, University of Erlangen Nuernberg, Krankenhausstr 12, 91054 Erlangen, Germany
    Hypertension 43:169-75. 2004
    ....
  43. ncbi Central nervous system norepinephrine metabolism in hypertension
    G W Lambert
    Human Neurotransmitters Laboratory, Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Curr Hypertens Rep 2:302-10. 2000
    ....
  44. ncbi The 'adrenaline hypothesis' of hypertension revisited: evidence for adrenaline release from the heart of patients with essential hypertension
    M S Rumantir
    Baker Medical Research Institute and Alfred Baker Medical Unit, Alfred Hospital, Melbourne, Australia
    J Hypertens 18:717-23. 2000
    ....
  45. ncbi Chronic placental insufficiency affects retinal development in the guinea pig
    Michelle Loeliger
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 45:2361-7. 2004
    ....
  46. ncbi Peripheral chemoreflex activation contributes to sympathetic baroreflex impairment in chronic heart failure
    Fabien Despas
    Institut National de la Sante et de la Recherche Medicale, UMR 1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
    J Hypertens 30:753-60. 2012
    ..Chemoreflex-mediated sympathetic activation contributes to both initiation and progression of chronic heart failure (CHF)...
  47. ncbi Total norepinephrine spillover, muscle sympathetic nerve activity and heart-rate spectral analysis in a patient with dopamine beta-hydroxylase deficiency
    J M Thompson
    Alfred Baker Medical Unit, Alfred Hospital, Victoria, Australia
    J Auton Nerv Syst 55:198-206. 1995
    ....
  48. ncbi Decreased catecholamine degradation associates with shock and kidney injury after cardiac surgery
    Anja Haase-Fielitz
    Department of Intensive Care, Austin Health, Melbourne, Australia
    J Am Soc Nephrol 20:1393-403. 2009
    ..In summary, this study identifies COMT LL homozygosity as an independent risk factor for shock, AKI, and hospital stay after cardiac surgery. (ClinicalTrials.gov number, NCT00334009)...
  49. ncbi Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: effects in human, rat and guinea-pig tissues in vitro and in pigs in vitro
    Kenneth D Winkel
    Department of Pharmacology, The University of Melbourne, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 32:777-88. 2005
    ..The venom may also contain a 'direct' vasoconstrictor component. These observations explain, at least in part, the clinical features of the potentially deadly Irukandji syndrome...
  50. ncbi Sex differences in postnatal growth and renal development in offspring of rabbit mothers with chronic secondary hypertension
    D Maduwegedera
    Department of Physiology, Monash University, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 292:R706-14. 2007
    ..The impact of a stimulated maternal renin-angiotensin system in the 2K-1W model of hypertension may influence development of the renal sympathetic nerves and contribute to programming of adult hypertension...
  51. ncbi Sympathetic activation and inflammatory response in patients with subarachnoid haemorrhage
    Silvana Naredi
    Department of Anaesthesiology and Intensive Care, Umea University Hospital, Umea, Sweden
    Intensive Care Med 32:1955-61. 2006
    ..The aim of this study was to evaluate the correlation between sympathetic nervous activation and the immune response in patients following subarachnoid haemorrhage (SAH)...
  52. ncbi Angiotensin II and norepinephrine release: interaction and effects on the heart
    Markus P Schlaich
    Department of Medicine IV, University of Erlangen Nuernberg, Germany
    J Hypertens 23:1077-82. 2005
    ..We investigated whether such an interaction is evident in the human heart and whether it has an impact on left ventricular (LV) structure...