Research Topics
| Judith A WhitworthSummaryAffiliation: Australian National University Country: Australia Publications
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Detail Information
Publications
Emerging drugs in the management of hypertensionJ A Whitworth
John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
Expert Opin Emerg Drugs 8:377-88. 2003....- Progression of renal failure -- the role of hypertensionJ A Whitworth
John Curtin School of Medical Research, Australian National University, Canberra ACT 0200, Australia
Ann Acad Med Singapore 34:8-15. 2005..Most patients will require combination drug therapy to control blood pressure and reduce both progression of renal failure and the associated cardiovascular morbidity and mortality... - The Wellcome Trust in Australasia: return on investmentJ A Whitworth
John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Intern Med J 34:211-4. 2004..Current initiatives are focused on development of research partnerships between Australasia and our regional neighbours... - Species variability in cardiovascular research: the example of adrenocorticotrophin-induced hypertensionJudith A Whitworth
The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
Clin Exp Pharmacol Physiol 33:887-91. 2006..3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans... - Cardiovascular consequences of cortisol excessJudith A Whitworth
John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Vasc Health Risk Manag 1:291-9. 2005..This review also details changes induced by short-term cortisol administration in normotensive healthy men... - Blood pressure and control of cardiovascular riskJudith A Whitworth
John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Vasc Health Risk Manag 1:257-60. 2005..This emphasis is reflected in the World Health Organization (WHO)-International Society of Hypertension (ISH) 2003 statement on management of hypertension... - Should eponyms be abandoned? NoJudith A Whitworth
John Curtin School of Medical Research, Australian National University, Canberra ACT 0200, Australia
BMJ 335:425. 2007 - Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the ratYuchun Miao
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Am J Hypertens 20:304-10. 2007.... - The antioxidant tempol prevents and partially reverses dexamethasone-induced hypertension in the ratYi Zhang
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
Am J Hypertens 17:260-5. 2004..Tempol prevented and partially reversed Dex-induced hypertension, independent of improvement in systemic oxidative stress measured by F(2)-isoprostane concentrations... - Apocynin but not L-arginine prevents and reverses dexamethasone-induced hypertension in the ratLexian Hu
High Blood Pressure Research Unit, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
Am J Hypertens 19:413-8. 2006.... - Effects of sepiapterin supplementation and NOS inhibition on glucocorticoid-induced hypertensionMya Thida
The High Blood Pressure Research Unit, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia
Am J Hypertens 23:569-74. 2010.... - Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the ratYi Zhang
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Canberra, Australia
Am J Hypertens 18:910-6. 2005..CONCLUSIONS: Apocynin but not allopurinol prevented and reversed ACTH-induced hypertension in the rat. These results suggest superoxide production through NAD(P)H oxidase plays a role in ACTH-induced hypertension... - The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertensionYi Zhang
High Blood Pressure Research Unit, John Curtin School of Medical Research, Building 131, Garran Road, Australian National University, Canberra, ACT 0200, Australia
J Hypertens 27:1609-16. 2009.... - Adrenocorticotropic hormone, blood pressure, and serum erythropoietin concentrations in the ratYi Zhang
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, GPO Box 334, Canberra, ACT 2601, Australia
Am J Hypertens 17:457-61. 2004..These data suggest that EPO is not causal in ACTH-induced hypertension... - Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in ratsChristopher G Schyvens
High Blood Pressure Research Unit, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
Clin Exp Hypertens 29:465-78. 2007..05). AA or alpha-tocopherol failed to prevent and alpha- or gamma-tocopherol failed to reverse ACTH-induced hypertension. Thus, neither vitamin C (water soluble) nor E (lipid soluble) modified ACTH-induced hypertension in the rat... - Aspirin prevents and partially reverses adrenocorticotropic hormone-induced hypertension in the ratYi Zhang
The High Blood Pressure Research Unit, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia
Am J Hypertens 20:1222-8. 2007..The aim of the present study was to investigate the effects of aspirin, a potent antioxidant, on adrenocorticotropic hormone (ACTH) and dexamethasone (Dex)-induced hypertension... - Role of xanthine oxidase in dexamethasone-induced hypertension in ratsSharon L H Ong
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Clin Exp Pharmacol Physiol 34:517-9. 2007..Allopurinol did not prevent dex-HT. This, together with our previous findings that allopurinol failed to prevent adrenocorticotrophic hormone induced hypertension, suggests that XO activity is not a major determinant of GC-HT in the rat... - Arachidonic acid metabolism in glucocorticoid-induced hypertensionYi Zhang
The High Blood Pressure Research Unit, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
Clin Exp Pharmacol Physiol 35:557-62. 2008..Urinary concentrations of the metabolites TXB(2) and PGI(2) were unchanged in both models of glucocorticoid-hypertension. The vasoconstrictor 20-HETE may play a role in the genesis of ACTH-induced hypertension... - The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in miceYi Zhang
Cardiovascular Research, The Canberra Hospital, Garran, ACT, Australia
Clin Exp Pharmacol Physiol 37:1044-8. 2010..Mineralocorticoid receptors do not appear to play a critical role in maintaining BP in glucocorticoid receptor deficient mice... - N-Acetylcysteine prevents but does not reverse dexamethasone-induced hypertensionSusanne Krug
The High Blood Pressure Research Unit, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
Clin Exp Pharmacol Physiol 35:979-81. 2008..N-Acetylcysteine had no effect on Dex-induced increased plasma F(2)-isoprostane concentrations. 6. In conclusion, NAC partially prevented, but did not reverse, Dex-induced hypertension... - Nitric oxide donation lowers blood pressure in adrenocorticotrophic hormone-induced hypertensive ratsMiles C Andrews
High Blood Pressure Research Unit, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia
Clin Exp Hypertens 26:499-509. 2004..It had no effect in control (saline treated) rats. In conclusion, the lowering of SBP by NO donation is consistent with the notion that ACTH-induced hypertension involves an impaired bioavailability or action of NO in vivo... - Lipopolysaccharide reverses adrenocorticotrophic hormone-induced hypertension in the ratYi Zhang
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Hypertens Res 26:427-32. 2003..8 mmHg; p<0.05). These data are compatible with the notion that reduced NO availability plays a role in ACTH-induced hypertension... - Reactive oxygen species and glucocorticoid-induced hypertensionSharon L H Ong
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Clin Exp Pharmacol Physiol 35:477-82. 2008..The role of mitochondrial reactive oxygen species in glucocorticoid-induced hypertension remains to be clarified... - The anti-oxidant Tempol reverses and partially prevents adrenocorticotrophic hormone-induced hypertension in the ratYi Zhang
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
J Hypertens 21:1513-8. 2003..Tempol treatment reversed, and pretreatment partially prevented ACTH-induced hypertension, independent of improvement in systemic oxidative stress... - Hemodynamic effects of the nitric oxide donor DETA/NO in miceChris G Schyvens
High Blood Pressure Research Unit, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
Clin Exp Hypertens 26:525-35. 2004..Again diethylenetriamine had no significant effect. There was no significant effect on body weight with any treatment. Thus DETA/NO has potent blood pressure lowering effects in both normotensive and hypertensive mice... - The nitric oxide system in glucocorticoid-induced hypertensionJudith A Whitworth
The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia
J Hypertens 20:1035-43. 2002.... - Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the ratY Zhang
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Clin Exp Hypertens 26:231-41. 2004..There was no significant difference in SBP between BH4 + ACTH treated and vehicle + ACTH treated rats. Thus, daily injection of BH4 (10 mg/kg i.p.) failed to prevent the development of ACTH-induced hypertension in rat... - Optimizing microarray in experimental hypertensionM Frances Shannon
John Curtin School of Medical Research, and Centre for Bioinformation Science, Australian National University, Acton, Australia
Kidney Int 67:364-70. 2005..The use of paired organs from an individual animal ensures even further genetic identity, allowing determination of genes modified by the treatment of interest... - The Sylvia and Charles Viertel Charitable Foundation: a decade of support for medical research in AustraliaJ A Whitworth
John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
Intern Med J 33:610-2. 2003..Its contribution to Australian medical research has centred on support of outstanding young people through Senior Medical Research Fellowships and a unique grant-in-aid programme for clinical investigators... - World health organisation-international society of hypertension (WHO/ISH) hypertension guidelinesJudith A Whitworth
The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia
Clin Exp Hypertens 26:747-52. 2004..It will be published in the Journal of Hypertension during 2003... - Decreased endothelial size and connexin expression in rat caudal arteries during hypertensionNicole M Rummery
Autonomic Synapse Group, Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Hypertens 20:247-53. 2002..Hypertension is accompanied by endothelial dysfunction. The present study has investigated endothelial cell morphology and connexin expression in the caudal artery of the rat during the development of hypertension... - 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertensionJudith A Whitworth
John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Hypertens 21:1983-92. 2003..In high-risk patients who attain large benefits from treatment, expensive drugs may be cost effective, but in low-risk patients treatment may not be cost-effective unless the drugs are cheap... - Telemetric monitoring of adrenocorticotrophin-induced hypertension in miceC G Schyvens
High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Clin Exp Pharmacol Physiol 28:758-60. 2001..This model will allow the selective use of transgenic and/or knockout mice to further elucidate the mechanism of ACTH- and steroid-induced hypertension... - Glucocorticoid-induced hypertension: from mouse to manJ A Whitworth
The John Curtin School of Medical Research, The Australian National University, Acton, Australian Capital Territory, Australia
Clin Exp Pharmacol Physiol 28:993-6. 2001..5. Abnormalities in glucocorticoid metabolism may contribute to some forms of 'essential' hypertension... - Acute effects of hydrocortisone on plasma nitrate/nitrite activity and forearm vasodilator responsiveness in normal human subjectsPaula M Williamson
Department of Medicine and Renal Medicine, St George Hospital, University of New South Wales, Kogarah, New South Wales, Australia
Clin Exp Pharmacol Physiol 32:162-6. 2005..If cortisol-induced hypertension is mediated by suppression of NO activity in humans, it seems likely that these changes take more than 3 h to become detectable... - L-arginine transport in humans with cortisol-induced hypertensionJaye P F Chin-Dusting
Alfred and Baker Medical Unit, Wynn Domain, Baker Heart Research Institute and Alfred Hospital, Prahran, Australia
Hypertension 41:1336-40. 2003..We conclude that cortisol-induced increases in blood pressure are not associated with abnormalities in the l-arginine transport system... - Tumor necrosis factor receptor 2 mRNA in rat models of hypertensionRuby C Y Lin
Basic and Clinical Genomics Laboratory, School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
Am J Hypertens 16:685-8. 2003..The ACTH-induced HT was not affected by huTNFR:Fc coadministration. The findings thus offer no support for altered Tnfr2 expression in the rat models studied... - Ganglion blockade does not prevent cortisol-induced hypertension in manPaula M Williamson
Department of Medicine, St George Hospital, University of New South Wales, Sydney, Australia
Clin Exp Pharmacol Physiol 32:294-6. 2005.... - Effect of synthetic corticosteroids on vascular reactivity in the human forearmGeorge J Mangos
Department of Medicine and Renal Medicine, St. George Hospital, University of New South Wales, Kogarah, Australia
Clin Exp Hypertens 28:707-18. 2006..These results do not support the notion that cortisol-induced vascular effects are mediated through classical corticosteroid receptors... - N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the ratCharles K Mondo
Institute of Cardiology, 2nd Hospital, Tianjin Medical University, Tianjin, PR China
Clin Exp Hypertens 28:73-84. 2006..001) but less than ACTH alone (p' < 0.05). In the reversal study, NAC had no significant effect (132 +/- 4 to 124 +/- 3 mmHg, ns). Thus, NAC partially prevented but did not reverse ACTH-induced hypertension... - Glucocorticoids and the kidneyGeorge J Mangos
Department of Medicine, St George Hospital, University of New South Wales, Kogarah, New South Wales, Australia
Nephrology (Carlton) 8:267-73. 2003..The present review considers three aspects of glucocorticoids with which nephrologists may be less familiar: (i) renal metabolism; (ii) effects on renal haemodynamics; and (iii) effects on blood pressure as they relate to the kidney... - Relationship between white blood cell count and incident hypertensionJudith A Whitworth
Am J Hypertens 17:861; author reply 861-2. 2004