Research Topics
Species | J A GravesSummaryAffiliation: Australian National University Country: Australia Publications
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Publications
The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammalsCarol A Edwards
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
BMC Evol Biol 7:157. 2007..There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome...- From brain determination to testis determination: evolution of the mammalian sex-determining geneJ A Graves
Research School of Biological Sciences, Australian National University, Canberra, ACT
Reprod Fertil Dev 13:665-72. 2001..The absence of SRY in two species of the mole vole (Ellobius) suggests that its useful life is already running out... - Sex and death in birds: a model of dosage compensation that predicts lethality of sex chromosome aneuploidsJ A M Graves
Research School of Biological Sciences, The Australian National University, Canberra, ACT, Australia
Cytogenet Genome Res 101:278-82. 2003..Reports of other aneuploids and triploids are also consistent with this hypothesis... - Sex from W to Z: evolution of vertebrate sex chromosomes and sex determining genesJ A Marshall Graves
Department of Genetics, LaTrobe University, Melbourne, Victoria 3083, Australia
J Exp Zool 290:449-62. 2001..J. Exp. Zool. 290:449-462, 2001... - The rise and fall of SRYJennifer A Marshall Graves
Research School of Biological Science, Australian National University, ACT 2601, Canberra, Australia
Trends Genet 18:259-64. 2002..At the observed rate of attrition, the human Y chromosome will be gone in 5-10 million years. This could lead to the extinction of our species or to a burst of hominid speciation... - Evolution of the human X--a smart and sexy chromosome that controls speciation and developmentJ A M Graves
Research School of Biological Science, Australian National University, Canberra, ACT, Australia
Cytogenet Genome Res 99:141-5. 2002..Here we will discuss the origin of the human X, and the evolution of dosage compensation and gene content, in the light of recent demonstrations that particular functions in sex and reproduction and cognition have accumulated on it... - Marsupial genetics and genomicsJennifer A Marshall Graves
Comparative Genomics Research Group, Research School of Biological Science, Australian National University, Canberra, ACT 2601, Australia
Trends Genet 18:517-21. 2002..We shamelessly present the case for a Kangaroo Genome Project... - Sex chromosomes and sex determination in weird mammalsJ A Marshall Graves
Research School of Biological Science, Australian National University, Canberra, Australia
Cytogenet Genome Res 96:161-8. 2002..Variant sex-determining systems in rodents show that the action of SRY can change, as it evidently has in the mouse, and SRY can be inactivated, as in akodont rodents, or even completely superseded, as in mole voles... - Sex chromosomes and sex-determining genes: insights from marsupials and monotremesA Pask
School of Genetics and Human Variation, La Trobe University, Melbourne, Vic, Australia
Cell Mol Life Sci 55:864-75. 1999..Here we review comparisons between genes in the sex-determining pathway in different vertebrates, and ask how these comparisons affect our views on the role of each gene in vertebrate sex determination... - The minimal mammalian Y chromosome - the marsupial Y as a model systemR Toder
Department of Genetics, La Trobe University, Bundoora, Melbourne, Victoria, Australia
Cytogenet Cell Genet 91:285-92. 2000..This minimal mammalian Y chromosome might provide a good model Y in which to hunt for new mammalian Y specific genes... - Evolution of the mammalian Y chromosome and sex-determining genesJ A Graves
School of Genetics and Human Variation, La Trobe University, Melbourne, Victoria, Australia
J Exp Zool 281:472-81. 1998..It is suggested here that, rather than acting as a transcriptional activator, the SRY gene acts to inhibit its paralogue SOX3, which in turn inhibits an ancient autosomal sex-determining gene SOX9... - Gene dosage in the evolution and function of mammalian sex chromosomesJ A Graves
School of Genetics and Human Variation, La Trobe University, Melbourne, Victoria, Australia
Cytogenet Cell Genet 80:94-103. 1998.... - The candidate sex-reversing DAX1 gene is autosomal in marsupials: implications for the evolution of sex determination in mammalsA Pask
School of Genetics and Human Variation, La Trobe University, Melbourne, Victoria, Australia
Genomics 41:422-6. 1997.... - The human Y chromosome derives largely from a single autosomal region added to the sex chromosomes 80-130 million years agoP D Waters
Department of Genetics, La Trobe University, Melbourne, Victoria, Australia
Cytogenet Cell Genet 92:74-9. 2001..Little of the ancient conserved region remains, and the human Y chromosome is largely derived from the added region... - The origin and evolution of the pseudoautosomal regions of human sex chromosomesJ A Graves
School of Genetics and Human Variation, La Trobe University, Melbourne, Victoria 3083, Australia
Hum Mol Genet 7:1991-6. 1998..We conclude that the PARs are relics of differential additions, loss, rearrangement and degradation of the Y chromosome in different mammalian lineages... - Interactions between SRY and SOX genes in mammalian sex determinationJ A Graves
School of Genetics and Human Variation, LaTrobe University, Melbourne, Victoria, Australia
Bioessays 20:264-9. 1998..The hypothesis also suggests a way that the dominant SRY sex-determining system of present-day mammals may have evolved from an ancient system relying on SOX3 dosage... - Sequences homologous to the human X- and Y-borne zinc finger protein genes (ZFX/Y) are autosomal in monotreme mammalsJ M Watson
Department of Genetics, LaTrobe University, Bundoora, Australia
Genomics 15:317-22. 1993..These results support the hypothesis that many of the genes located on the short arm of the human X were originally autosomal and have been translocated to the X chromosome since the eutherian-metatherian divergence... - Mammals that break the rules: genetics of marsupials and monotremesJ A Graves
School of Genetics and Human Variation, La Trobe University, Melbourne, Victoria, Australia
Annu Rev Genet 30:233-60. 1996..In many features, it appears that humans and, particularly, mice are the weird mammals that break more general mammalian, or even vertebrate rules... - Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining roleM C Wallis
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra, Australia
Cytogenet Genome Res 116:232-4. 2007..The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus... - DMRT1 in a ratite bird: evidence for a role in sex determination and discovery of a putative regulatory elementS Shetty
Department of Genetics, La Trobe University, Bundoora, Victoria, Australia
Cytogenet Genome Res 99:245-51. 2002..This extraordinarily high conservation across 300 million years of evolution suggests an important function, perhaps involved in control of DMRT1 expression and vertebrate sex determination... - Assignment of the thymosin beta 4 X/Y chromosome (TMSB4X/Y) gene to tammar wallaby chromosome 5p by fluorescence in situ hybridisationP D Waters
Comparative Genomics Group, Research School of Biological Science, The Australian National University, Canberra, Australia
Cytogenet Genome Res 103:203F. 2003 - Cloning and mapping of platypus SOX2 and SOX14: insights into SOX group B evolutionP J Kirby
Department of Genetics, La Trobe University, Bundoora, Victoria, Australia
Cytogenet Genome Res 98:96-100. 2002..The sequence similarity and conserved synteny of these group B genes provide clues to their origin. A simple model of SOX group B gene evolution is proposed... - The origin and function of the mammalian Y chromosome and Y-borne genes--an evolving understandingJ A Graves
School of Genetics and Human Variation, La Trobe University, Melbourne, Victoria, Australia
Bioessays 17:311-20. 1995..Although the gonadogenesis pathway is highly conserved in vertebrates, its control has probably changed radically and rapidly in vertebrate--even mammalian--evolution... - Review: Sex chromosome evolution and the expression of sex-specific genes in the placentaJ A M Graves
Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia
Placenta 31:S27-32. 2010..Imprinted paternal X inactivation in rodent extraembryonic tissues would be expected to mitigate the effect of foreign paternal antigens; however, paternal inactivation seems not to occur in the human placenta... - Class I genes have split from the MHC in the tammar wallabyJ E Deakin
ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, Australia
Cytogenet Genome Res 116:205-11. 2007..It highlights the need for the inclusion of more than one marsupial species in comparative studies and raises questions regarding the functional significance of the clustering of MHC genes... - A new look at the evolution of avian sex chromosomesR Stiglec
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra, Australia
Cytogenet Genome Res 117:103-9. 2007..Here we examine recent research into avian sex chromosomes and offer alternative suggestions as to their evolution... - Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremesM C Wallis
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
Chromosome Res 15:949-59. 2007..Sex determination in platypus and echidna must therefore depend on another male-determining gene(s) on the Y chromosomes, or on the different dosage of a gene(s) on the X chromosomes... - Assignment of the DMRT1 gene to tammar wallaby chromosome 3p by fluorescence in situ hybridizationN El-Mogharbel
Comparative Genomics Group, Research Schol of Biological Sciences, Australian National University, Canberra ACT, Australia
Cytogenet Genome Res 108:362. 2005 - Assignment of the glucose-6-phosphate dehydrogenase (G6PD) gene to tammar wallaby chromosome Xq by fluorescence in situ hybridization with a BAC cloneE Koina
The ARC Centre for Kangaroo Genomics, Compararative Genonmic Group, Research Chool of Biological Science, The Australian National University, Canberra ACT, Australia
Cytogenet Genome Res 108:362. 2005 - Marsupial WT1 has a novel isoform and is expressed in both somatic and germ cells in the developing ovary and testisA J Pask
Department of Zoology, The University of Melbourne, Melbourne, Vic, Australia
Sex Dev 1:169-80. 2007..Our data suggest that WT1 has a conserved function in both the somatic and germ cell lineages of the gonads of marsupials... - Assignment of the eukaryotic translation initiation factor (EIF2S3) to tammar wallaby chromosome 5p by in situ hybridizationM L Delbridge
Comparative Genomics Group, Research School of Biological Sciences, The Austalian National University, Canberra
Cytogenet Genome Res 107:139. 2004 - Reassignment of chicken W chromosome sequences to the Z chromosome by fluorescence in situ hybridization (FISH)R Stiglec
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra, Australia
Cytogenet Genome Res 116:132-4. 2007..Our results demonstrate that the 17 genes on these BACs are Z-specific, and points to the inadequacy of assigning regions of the genome based exclusively on repetitive sequences... - Histone underacetylation is an ancient component of mammalian X chromosome inactivationM J Wakefield
School of Genetics and Human Variation, La Trobe University, Bundoora, Melbourne, 3083, Australia
Proc Natl Acad Sci U S A 94:9665-8. 1997.... - The X--a sexy chromosomeJ A Graves
Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
Bioessays 23:1091-4. 2001..We suggest experiments to distinguish these possibilities, and speculate on the implications of gathering evidence that genes with other functions, too, are not distributed uniformly over the genome... - Sex determination in mammals--before and after the evolution of SRYM C Wallis
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT, 2601, Australia
Cell Mol Life Sci 65:3182-95. 2008..This suggests that the therian X and Y, and the SRY gene, evolved from an ancient bird-like sex chromosome system which predates the divergence of mammals and reptiles 310 MYA... - Assignment of the protocadherin 20 (PCDH20) gene to tammar wallaby chromosome 6q by fluorescence in situ hybridisationP D Waters
Comparative Genomics Group, Research Group of Biological Science, The Australian National University, Canberra 2601, Australia
Cytogenet Genome Res 98:311D. 2002 - Isolation of chromosomal regions controlling intersex development in a marsupialC Santucciu
Research School of Biological Sciences, The Australian National University, Canberra, Australian Capital Territory, Australia
Cytogenet Genome Res 101:224-8. 2003..This could represent a region of the X that contains, as well as PMS, repetitive DNA that is present also at other chromosomal sites... - Assignment of the proteolipid protein 1 gene (PLP1) to tammar wallaby chromosome Xq by fluorescence in situ hybridization with a BAC cloneE Koina
The ARC Centre for Kangaroo Genomics, Comparative Genomics Group, Research School of Biological Science, The Australian National University, Canberra, Australia
Cytogenet Genome Res 114:94F. 2006 - The human/mouse imprinted genes IGF2, H19, SNRPN and ZNF127 map to two conserved autosomal clusters in a marsupialR Toder
School of Genetics and Human Variation, La Trobe University, Melbourne, Australia
Chromosome Res 4:295-300. 1996..The autosomal location of these clusters does not suggest a recent evolutionary relationship between imprinting and X chromosome inactivation... - Physical mapping of immunoglobulin loci IGH@, IGK@, and IGL@ in the opossum (Monodelphis domestica)J E Deakin
ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, Australia
Cytogenet Genome Res 114:94H. 2006 - Assignment of SOX1 to platypus chromosome 20q by fluorescence in situ hybridizationM L Delbridge
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra, Australia
Cytogenet Genome Res 112:342L. 2006 - Sequencing and mapping hemoglobin gene clusters in the Australian model dasyurid marsupial Sminthopsis macrouraA A De Leo
Department of Zoology, The University of Melbourne, Melbourne, Vic, Australia
Cytogenet Genome Res 108:333-41. 2005..macroura alpha and beta globin genes located the beta globin cluster on chromosome 3q and the alpha locus close to the centromere on 1q, resolving contradictory map locations obtained by previous radioactive in situ hybridization... - Genomic imprinting, development and disease--is pre-eclampsia caused by a maternally imprinted gene?J A Graves
School of Genetics and Human Variation, La Trobe University, Melbourne, Vic, Australia
Reprod Fertil Dev 10:23-9. 1998..This could be resolved by proposing that the condition is due to mutation in a paternally imprinted, maternally active gene which must be expressed by the fetus in order to establish a normal placenta in the first pregnancy... - Physical mapping of T cell receptor loci (TRA@, TRB@, TRD@ and TRG@) in the opossum (Monodelphis domestica)J E Deakin
ARC Centre for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, Australia
Cytogenet Genome Res 112:342K. 2006