Research Topics
| F L RosenfeldtSummaryAffiliation: Alfred Hospital Country: Australia Publications
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Detail Information
Publications
Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trialsF L Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital, Melbourne, Australia
J Hum Hypertens 21:297-306. 2007..3 (8.4-12.3, P<0.001) mm Hg. We conclude that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects...- Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failureFranklin Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Melbourne, Victoria, Australia
Biofactors 18:91-100. 2003..Further trials of CoQ10 in physical exercise and in hypertension are recommended... - Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q10 therapyFranklin L Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia
Int J STD AIDS 16:827-9. 2005..This suggests a novel therapy for further investigation targeted at ZDV induced myopathy, potentially allowing continuation of antiviral treatments including ZDV... - The clinical application of metabolic therapy for cardiovascular diseaseAnthony Hadj
Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital and Baker Heart Research Institute, Victoria, Australia
Heart Lung Circ 16:S56-64. 2007.... - Initial clinical experience with the VentrAssist left ventricular assist device: the pilot trialDonald S Esmore
Department of Cardiothoracic Surgery, Alfred Hospital, Prahran, Victoria, Australia
J Heart Lung Transplant 27:479-85. 2008..The VentrAssist (VA) is a novel, continuous flow left ventricular assist device (LVAD). The purpose of this trial was to investigate the safety and efficacy of the VA in elderly patients with end-stage heart failure... - Coronary artery bypass surgery provides long-term results superior to percutaneous coronary interventionFranklin L Rosenfeldt
Department of Surgery, The University of Melbourne, Australia
Heart Lung Circ 21:1-11. 2012.... - Occlusive wrap dressing reduces infection rate in saphenous vein harvest siteFranklin L Rosenfeldt
Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Victoria, Australia
Ann Thorac Surg 75:101-5; discussion 105. 2003..Data were collected in the hospital and then 4 to 6 weeks postoperatively. Superficial and deep wound infections were defined by the standard criteria from the Centers for Disease Control and Prevention... - The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardiumFranklin L Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital, Baker Institute, Melbourne, Australia
Biogerontology 3:37-40. 2002..4) Oral CoQ10 therapy before cardiac surgery improves efficiency of mitochondrial energy production, improves post-operative heart function, reduces intra-operative myocardial damage and shortens hospital stay... - Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patientsFranklin L Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Prahran 3181, Australia
Ann N Y Acad Sci 959:355-9; discussion 463-5. 2002..We hypothesized that CoQ10 pretreatment prior to stress could improve the recovery of the myocardium after stress... - Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological ageFranklin Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute Wynn Domain, Melbourne, Prahran Victoria 3181, Australia
Ann N Y Acad Sci 1019:78-84. 2004.... - Physical conditioning and mental stress reduction--a randomised trial in patients undergoing cardiac surgeryFranklin Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital, Department of Surgery, Monash University, Baker IDI Institute Melbourne, Australia
BMC Complement Altern Med 11:20. 2011..Secondary aims were to evaluate the effect of these programs on quality of life (QOL), rates of postoperative atrial fibrillation (AF) and length of stay (LOS) in hospital... - Weak beta-adrenoceptor-mediated relaxation in the human internal mammary arteryG W He
Baker Medical Research Institute, Melbourne, Australia
J Thorac Cardiovasc Surg 97:259-66. 1989..We conclude that beta-adrenoceptors would contribute little to the reactivity of the human internal mammary artery graft to sympathomimetic drugs... - Pharmacological relaxation of the saphenous vein during harvesting for coronary artery bypass graftingG W He
Baker Medical Research Institute, Melbourne, Australia
Ann Thorac Surg 55:1210-7. 1993..We now use a mixture of glyceryl trinitrate and verapamil (pH 7.4) topically and intraluminally during harvesting of the saphenous vein to provide a relaxed conduit for coronary artery bypass grafting... - Mitral valve replacement via a right mini-thoracotomy in the dog: use of carbon dioxide to reduce intracardiac airW S Peters
Cardiac Surgical Research Unit, Baker Medical Research Institute, Prahran Vic, Australia
Eur J Cardiothorac Surg 11:1067-73. 1997..To develop a clinically applicable method of minimally invasive mitral valve replacement (MVR) with cardioplegia, and examine the ability of carbon dioxide (CO2) to improve de-airing... - Effect of multiorgan donation after cardiac death retrieval on lung performanceGregory I Snell
Lung Transplant Service, Alfred Hospital and Monash University, Melbourne, Victoria, Australia
ANZ J Surg 78:262-5. 2008..Although there are several novel individual techniques recently described for DCD lung donation, they have not been evaluated or compared in a DCD multiorgan scenario... - Total leukocyte control for elective coronary bypass surgery does not improve short-term outcomeRobert F Salamonsen
Department of Intensive Care, Alfred Hospital, Melbourne, Australia
Ann Thorac Surg 79:2032-8. 2005..Despite early promise as a means of reducing the inflammatory response to surgery and subsequent organ damage, the evidence of the clinical value of leukocyte filtration remains equivocal... - Evaluation of techniques for lung transplantation following donation after cardiac deathGregory I Snell
Lung Transplant Service, Alfred Hospital, Monash University, Melbourne, Australia
Ann Thorac Surg 81:2014-9. 2006.... - Similar therapeutic serum levels attained with emulsified and oil-based preparations of coenzyme Q10W Lyon
Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Melbourne, Victoria, Australia
Asia Pac J Clin Nutr 10:212-5. 2001..There was no change in any of the serum lipids following the 7 days treatment. We conclude that administration of either a soy oil suspension or a complex emulsion of CoQ10 increases serum levels to the therapeutic range within 1 week... - Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissueFranklin Rosenfeldt
The Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital, Baker Heart Research Institute, Melbourne, Australia
J Thorac Cardiovasc Surg 129:25-32. 2005.... - Pharmacology of coronary artery bypass graftsF L Rosenfeldt
Cardiac Surgical Research Laboratory, Baker Medical Research Institute and Alfred Hospital, Prahran, Victoria, Australia
Ann Thorac Surg 67:878-88. 1999.... - Aspartate improves recovery of the recently infarcted rat heart after cardioplegic arrestF L Rosenfeldt
Cardiac Surgical Research Unit, Baker Medical Research Institute and Alfred Hospital, Melbourne, Australia
Eur J Cardiothorac Surg 14:185-90. 1998..We have previously shown that aspartate improves the tolerance of normal hearts to cardioplegia. The aim of this study was to investigate whether aspartate is also beneficial in the recently infarcted heart... - Minimally invasive right heart operations: techniques for bicaval occlusion and cardioplegiaW S Peters
Department of Cardiac Surgical Research, Baker Medical Research Institute, Melbourne, Australia
Ann Thorac Surg 64:1843-5. 1997..In 4 canine studies, three variants of bicaval cannulation techniques were successfully used for atrial septal defect repair via a right minithoracotomy... - Extracorporeal membrane oxygenation after lung transplantation: evolving technique improves outcomesTakahiho Oto
Heart and Lung Transplant Unit, The Alfred Hospital, Monash University Medical School, Melbourne, Vic, Australia
Ann Thorac Surg 78:1230-5. 2004..Extracorporeal membrane oxygenation (ECMO) may provide lifesaving temporary support; however, its longer-term efficacy is controversial... - Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNAFrancis Miller
Cardiac Surgical Research Unit, Alfred Hospital, Dept of Surgery, Monash University, and Baker Heart Research Institute, Commercial Road Prahran, Victoria 3181, Australia
Mech Ageing Dev 130:742-7. 2009..We conclude that, although mtDNA mutations (as exemplified by mtDNA(4977)) accumulate in the ageing heart, they are unlikely to make a major contribution to loss of contractile function... - A practical approach to clinical lung transplantation from a Maastricht Category III donor with cardiac deathTakahiro Oto
Lung Transplant Service, The Alfred Hospital and Monash University, Melbourne, Australia
J Heart Lung Transplant 26:196-9. 2007.... - Techniques of reconstruction for inadequate donor left atrial cuff in lung transplantationTakahiro Oto
Department of Cardiothoracic Surgery, The Alfred Hospital, Monash University, Melbourne, Australia
Ann Thorac Surg 81:1199-204. 2006..This study aims to describe the incidence, efficacy, and various techniques of LA cuff reconstruction in lung transplantation... - Focal cerebral oxygenation and neurological outcome with or without brain tissue oxygen-guided therapy in patients with traumatic brain injuryA A Adamides
Department of Neurosurgery, Alfred Hospital, Prahran, Victoria 3181, Australia
Acta Neurochir (Wien) 151:1399-409. 2009..This study aimed to evaluate the efficacy of brain oxygen-guided therapy in improving cerebral oxygenation and neurological outcome in severe TBI patients... - Antioxidant therapy for severe cardiac failure induced by iron overload secondary to dyserythropoietic anaemiaJuliana van der Merwe
Department of Cardiothoracic Surgery, Melbourne, Victoria, Australia
Heart Lung Circ 16:394-7. 2007..This therapy may have wider application in refractory heart failure and in the prevention of cardiomyopathy in patients receiving regular red cell transfusions who are at risk of transfusional haemosiderosis... - Early outcomes comparing Perfadex, Euro-Collins, and Papworth solutions in lung transplantationTakahiro Oto
Heart and Lung Transplant Unit, The Alfred Hospital, Melbourne, Australia
Ann Thorac Surg 82:1842-8. 2006..Switching preservation solution from Euro-Collins (or Papworth) to Perfadex would appear to usefully contribute to a strategy to reduce PGD in lung transplantation... - Pre-operative preparation for cardiac surgery utilising a combination of metabolic, physical and mental therapyAnthony Hadj
Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Monash University, Alfred Hospital, Melbourne, Vic, Australia
Heart Lung Circ 15:172-81. 2006.... - High-flow endobronchial cooled humidified air protects non-heart-beating donor rat lungs against warm ischemiaTakahiro Oto
Heart and Lung Transplant Unit, The Alfred Hospital, Monash University, Melbourne, Australia
J Thorac Cardiovasc Surg 132:413-9. 2006..CONCLUSIONS: High-flow endobronchial cooled humidified air can decrease lung temperature and improve post-ischemic pulmonary function and adenosine triphosphate levels in non-heart-beating donor lungs... - A reinforced sternal wiring technique for transverse thoracosternotomy closure in bilateral lung transplantation: from biomechanical test to clinical applicationTakahiro Oto
Department of Cardiothoracic Surgery, Heart and Lung Transplant Unit, The Alfred Hospital, Monash University, Melbourne, Australia
J Thorac Cardiovasc Surg 134:218-24. 2007..The aims of this study were to investigate the biomechanical and clinical efficacy of the proposed reinforced sternal closure technique... - Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mousePhyllis Chew
Oxidative Stress Laboratory, Diabetes Division, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
Diabetes 59:3198-207. 2010..To investigate the effect of the GPx1-mimetic ebselen on diabetes-associated atherosclerosis and renal injury in a model of increased oxidative stress... - Extended pericardiotomy avoids cardiopulmonary bypass during bilateral sequential lung transplantationTakahiro Oto
Department of Cardiothoracic Surgery, The Alfred Hospital, Monash University, Melbourne, Australia
J Thorac Cardiovasc Surg 129:466-7. 2005 - Early institution of mechanical support improves outcomes in primary cardiac allograft failureSilvana F Marasco
CJOB Cardiothoracic Surgery Unit, The Alfred Hospital, Melbourne, Australia
J Heart Lung Transplant 24:2037-42. 2005.... - Coenzyme Q10 in cardiovascular diseaseSalvatore Pepe
CJOB Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Australia
Mitochondrion 7:S154-67. 2007..3. Presently, due to the notable absence of clinically significant side effects and likely therapeutic benefit, CoQ(10) can be considered a safe adjunct to standard therapies in cardiovascular disease... - Heterotopic heart transplantation: an expanding role in the twenty-first century?Andrew E Newcomb
Heart and Lung Transplantation Service, Alfred Hospital, Melbourne, Victoria, Australia
Ann Thorac Surg 78:1345-50; discussion 1350-1. 2004..87). Kaplan-Meier survival analysis of survival was performed. CONCLUSIONS: Heterotopic heart transplantation is a viable transplant option for selected high-risk heart transplant recipients in spite of somewhat poorer outcomes... - Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with ageFrancis J Miller
Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Institute, Commercial Road, Prahran, Victoria 3181, Australia
Nucleic Acids Res 31:e61. 2003..This PCR-based assay not only enables accurate determination of mtDNA relative to nuclear DNA but also has the potential to quantify accurately any DNA sequence in relation to any other... - First clinical implant of the VentrAssist left ventricular assist system as destination therapy for end-stage heart failureDonald S Esmore
Department of Cardiothoracic Surgery, Alfred Hospital, Prahran, Victoria, Australia
J Heart Lung Transplant 24:1150-4. 2005..The implant and recovery were uneventful, and the patient survives at 17 months, is NYHA class II, and lives at home. This device shows promise in end-stage heart failure for permanent implantation and bridge to transplantation... - Mechanical circulatory support for the failing heart: past, present and futureDonald Esmore
Heart Lung Circ 14:163-6. 2005 - What is the role of leukocyte depletion in cardiac surgery?Hou Kiat Lim
Cardiac Surgical Research Unit, Alfred Hospital, Melbourne, Australia
Heart Lung Circ 16:243-53. 2007..Future trials should be powered to detect important clinical end points and be designed to avoid premature exhaustion of the filter... - The split radial technique: an alternative to the Y-graft for total arterial myocardial revascularisationDonald S Esmore
Department of Cardiothoracic Surgery, Alfred Hospital and Cardiac Surgical Research Unit-Alfred Hospital and Baker Medical Research Institute, The Alfred, Commercial Road, Melbourne, Vic. 3004, Australia
Heart Lung Circ 14:32-5. 2005..We describe the split radial technique of constructing two aorto-coronary graft segments from a single radial artery that can be used to avoid the use of Y-grafts... - Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpressionOlivier W V van den Brink
Department of Cardiothoracic Surgery, Alfred Hospital and Department of Surgery, Monash University, Melbourne, Australia
J Renin Angiotensin Aldosterone Syst 8:153-9. 2007..The goal of this investigation was to examine how cardiac levels of enkephalin production are altered in the development of normotensive primary hypertrophy due to elevated intra-cardiac angiotensin II (Ang II) production... - Initial in vivo experience of the VentrAssist implantable rotary blood pump in sheepAnita L van der Meer
VentrAssist Division, Ventracor Ltd, Sydney, New South Wales, Australia
Artif Organs 27:21-6. 2003..These studies demonstrate the suitability of the animal model for evaluation of the VentrAssist rotary blood pump. Further in vivo studies prior to preclinical trials are in progress... - In vitro comparison of glyceryl trinitrate-verapamil with other dilators of human saphenous veinL S Bruno Jesuthasan
Cardiac Surgical Research Unit, The Alfred Hospital and Baker Institute, Department of Pharmacology, The University of Melbourne, Melbourne, Australia
ANZ J Surg 73:313-20. 2003..ii) GTN-V combination is a potent combination causing a maximum dilator effect that is significantly greater than single agents including SNP and N...