Giuseppe Argenziano

..In this article, we intend to extract some of the salient points from published clinical and molecular studies on melanocytic tumors and attempt to assimilate them into an integrative concept of nevogenesis...

..The value of total body skin examination (TBSE) for skin cancer screening is controversial...

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..Objective To examine clinical outcome and patient compliance using different follow-up protocols...

..We initially evaluated five cases and found that none had baseline features suggestive of melanoma; excision was performed based on slight changes visible only in side-by-side comparisons of dermoscopic images...

..Most dermoscopic algorithms to diagnose melanoma were established more than 10?years ago and have been tested primarily on clear-cut melanomas and excised melanocytic naevi...

..To assess the outcome on management recommendations of a comparative approach vs a morphologic approach in evaluating dermoscopic images of lesions from a series of patients with multiple nevi...

..The natural evolution of melanocytic nevi is a complex, multifactorial process that can be studied by monitoring nevi on a long-term basis...

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..Dermoscopy improves melanoma recognition, but most criteria were described in the context of superficial spreading melanoma...

..Dermoscopy has been shown to increase the diagnostic accuracy of clinically equivocal lesions, but little is known about its ability to detect melanoma in the context of lesions that appear clinically benign...

..Teledermoscopy represents a useful tool for the diagnosis of acral melanoma and for the categorization of patterns that suggest benign or potentially malignant acral melanocytic lesions...

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..Asymmetry should be assessed using both dermoscopic and histopathologic analysis, and reliability in histopathologic diagnosis may be enhanced by the simultaneous evaluation of the corresponding dermoscopic images...

..The aim of this randomized study was to determine whether the adjunct of dermoscopy to the standard clinical examination improves the accuracy of PCPs to triage lesions suggestive of skin cancer...

..Sclerosing nevi with pseudomelanomatous features or, else, nevi with regression-like fibrosis (NRLF) are histopathologic simulators of regressing melanoma...

..CONCLUSIONS: Teleconsultation of dermoscopic images of pigmented skin lesions via e-mail provides a similar degree of diagnostic accuracy as face-to-face diagnosis when the diagnosis is made by a dermatologist confident with dermoscopy...

..Lesions showing clear-cut regression structures are prone to give some histopathologic disagreement...

..Early detection of basal cell carcinoma (BCC) is crucial to reduce the morbidity of this tumor...

..In recent years, several histopathologic variants of blue nevus have been identified, whose clinical and dermoscopic correlates need further clarification...

..To investigate changes in dermoscopic patterns of acquired acral melanocytic nevi (AAMN) over time...

..To describe the different vascular structures seen by dermoscopy and to evaluate their association with various melanocytic and nonmelanocytic skin tumors in a large series of cases...

..Recent studies demonstrating accuracy of teledermatology and teledermoscopy in the evaluation of pigmented skin lesions (PSL) have been performed only on PSL previously selected by face-to-face examination...

..Such a finding further expands the histopathologic spectrum of mycosis fungoides and could be taken into account in its differential diagnosis from granuloma annulare, inflammatory morphea, and interstitial granulomatous drug reaction...

..We tested the relevance of clinical information in the histopathologic evaluation of melanocytic skin neoplasm (MSN)...

..The theoretic and practical aspects of a close interaction among dermoscopists and histopathologists are itemized in detail...

..53). CONCLUSION: The virtual Consensus Net Meeting on Dermoscopy represents a valid tool for better standardization of the dermoscopic terminology and, moreover, opens up a new territory for diagnosing and managing pigmented skin lesions...

..A 62-year-old man presented with the unusual association of acrokeratosis verruciformis of Hopf and multiple keratoacanthomas. Both conditions were treated successfully with acitretin...

..Finally, a hint to the use of cytodiagnosis for basal cell carcinoma is provided...

..In this case step-sections of the sample were deemed to be required for definite diagnosis. The combined approach was helpful in detecting macroscopic and microscope sampling errors of melanocytic lesions during teleconsultation...

..Development of melanocytic nevi is a complex process...

..Routine clinicopathologic practice is expected to refine/validate the scoring system proposed in 2005 by the International Society for Cutaneous Lymphomas (ISCL) for the diagnosing early mycosis fungoides (eMF), classical type...

..CONCLUSION: Dermoscopy and digital follow up might be the key factors to improve the knowledge about the natural evolution of nevi and melanoma and the spectrum of undefined melanocytic proliferations...

..For the distinction between MIS and atypical naevi, the extension of an atypical network, the presence of more than one type of network, the distribution of reticular grey-blue areas and the lesion diameter must be considered...

..The starburst pattern is the dermoscopic hallmark of pigmented Spitz nevus, although it has been rarely observed in melanoma as well...

..We report 2 patients with EP and discuss the diagnostic significance of the observed dermoscopic findings...

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..The diagnosis of pediatric atypical Spitz nevus/tumors (pASNT) is an emerging challenge in clinical dermatology and dermatopathology...

..In addition, conflicting data are available on other potential low-penetrance genes encoding proteins involved in pigmentation, cell growth and differentiation, DNA repair or detoxifying of metabolites...

..Lentigo maligna is mainly diagnosed in the elderly with severely sun-damaged skin...

..To subclassify acquired nevi by dermoscopic pattern...

..Herein we describe the clinical, dermoscopic and histopathological findings in a patient affected by GF and its response to long-term topical treatment with tacrolimus 0.1% cream...

..Our findings confirm that CBN is a distinctive variant of blue nevus that may mimic cutaneous melanoma both clinically and dermoscopically...

..Recently we reported the usefulness of epiluminescence microscopy (dermatoscopy) for in vivo detection of the phases of melanoma progression, as well as tumor depth...

..Little is known about the possible influence of associated clinical features on the reliability of dermoscopic diagnosis during in vivo examination...

..CONCLUSIONS: We demonstrated that Web-based training is an effective tool for teaching dermoscopy...

..However, the term 'dermoscopy', first used by Friedman and colleagues in 1991, is the most widely used...

..The need to establish more reliable epiluminescence microscopic and HP criteria by performing an improved and meticulous clinicopathologic correlation, e.g. by using telecommunication via Internet, is emphasized...

..We also classified small- and medium-sized congenital naevi (CN) into nine subtypes according to their macroscopic and dermoscopic aspects...

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..5% of SECN. Histopathologically, this network corresponds to focal areas of pigmented parakeratosis, producing a black reticulated appearance on the horizontal plane...

..Diagnosis by scrape cytology in ruling-out basal cell carcinoma and other ulcerative skin diseases is discussed and the importance of neurological examination in disclosing hemi-anaesthesia of trigeminal dermatome(s) is emphasized...

..A definite hypodiploid peak was associated with worse prognosis. The analysis of cyclin D1 expression and DNA ploidy may help identify BCC with an aggressive phenotype and a poor clinical outcome...

..The case presented here refers to a melanoma clinically simulating dermatofibroma that was biopsied because dermoscopic examination revealed unusual features that did not confirm the clinical diagnosis...

..Moreover, we discuss recent concepts regarding nevogenesis and highlight some controversial aspects regarding childhood melanoma...

..9% and was significantly influenced by the profession, with dermatologists performing best. CONCLUSIONS: Our study confirms that the three-point checklist is a feasible, simple, accurate and reproducible skin cancer screening tool...

..This observation may help in the early recognition of some 'banal'-appearing melanomas. Furthermore, the observations made in this study raise interesting questions regarding naevus evolution...

..9%) and involving > 50% of the lesion surface (47.8%). CONCLUSIONS: Using degree and type of BWS, an algorithm was constructed that can be applied for the management of lesions exhibiting dermoscopic features of regression...

..The accuracy of clinical diagnosis of nonpigmented, facial actinic keratosis (AK) is often suboptimal, even for experienced clinicians...

..In pigmented BD, small brown globules and/or homogeneous pigmentation can be seen as well...

..Dermoscopic criteria appeared to be independent of CMIS lesions size...

..Amelanotic malignant melanoma is a subtype of cutaneous melanoma with little or no pigment on visual inspection. It may mimic benign and malignant variants of both melanocytic and nonmelanocytic lesions...