Research Topics
Species | Diego A GolombekSummaryAffiliation: Universidad Nacional de Quilmes Country: Argentina Publications
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Publications
Physiology of circadian entrainmentDiego A Golombek
Laboratory of Chronobiology, Department of Science and Technology, University of Quilmes Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Quilmes, Argentina
Physiol Rev 90:1063-102. 2010..Finally, we describe and analyze clock gene expression and its importance in entrainment mechanisms, as well as circadian disorders or retinal diseases related to entrainment deficits, including experimental and clinical treatments...- From light to genes: moving the hands of the circadian clockDiego A Golombek
Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
Front Biosci 8:s285-93. 2003..These mechanisms lead to expression of specific clock genes which eventually set the phase of the clock and of clock-controlled circadian rhythms... - "Time sweet time": circadian characterization of galectin-1 null miceLeandro P Casiraghi
Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Argentina
J Circadian Rhythms 8:4. 2010..To further analyze the role of endogenous galectin-1 in vivo, we aimed to characterize the circadian behavior of galectin-1 null (Lgals1-/-) mice... - [Sleep is rhythm (and the rhythm, rhythm is)]Diego A Golombek
Universidad Nacional de Quilmes CONICET, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
Vertex 18:283-7. 2007.... - Signaling in the mammalian circadian clock: the NO/cGMP pathwayDiego A Golombek
Laboratory of Chronobiology, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 180, Bernal 1876, Buenos Aires, Argentina
Neurochem Int 45:929-36. 2004..This pathway offers a signaling window that allows peering into the circadian clock machinery in order to decipher its temporal cogs and wheels... - Diurnal, circadian and photic regulation of calcium/calmodulin-dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nucleiPatricia V Agostino
, Universidad Nacional de Quilmes, , Bernal 1876, Buenos Aires, Argentina
Neurochem Int 44:617-25. 2004.... - Paying the circadian toll: the circadian response to LPS injection is dependent on the Toll-like receptor 4Natalia Paladino
Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
J Neuroimmunol 225:62-7. 2010..In conclusion, we show that LPS-induced circadian responses are mediated by TLR4... - Circadian entrainment to light-dark cycles involves extracellular nitric oxide communication within the suprachiasmatic nucleiSantiago A Plano
Department of Science and Technology, Laboratory of Chronobiology, National University of Quilmes CONICET, Buenos Aires, Argentina
Eur J Neurosci 31:876-82. 2010..e. the time for light-induced phase advances). These findings demonstrate the role of extracellular NO communication within the SCN in the steady-state synchronization to LD cycles... - Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to lightMarcelo E Katz
Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
Pharmacol Biochem Behav 90:763-8. 2008.... - Effect of experimental glaucoma on the non-image forming visual systemNuria de Zavalía
Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Departamento de Bioquimica Humana, Facultad de Medicina CEFyBO, Universidad de Buenos Aires CONICET, Paraguay, Buenos Aires, Argentina
J Neurochem 117:904-14. 2011..These results indicate the glaucoma induced significant alterations in the non-image forming visual system... - Timing of locomotor activity circadian rhythms in Caenorhabditis elegansSergio H Simonetta
Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes and National Research Council CONICET, Buenos Aires, Argentina
PLoS ONE 4:e7571. 2009..Our analysis of circadian rhythmicity in C. elegans opens the possibility for further screening for circadian mutations in this species... - Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedulesPatricia V Agostino
Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, 1876 Buenos Aires, Argentina
Proc Natl Acad Sci U S A 104:9834-9. 2007..These results suggest that sildenafil may be useful for treatment of circadian adaptation to environmental changes, including transmeridian eastbound flight schedules... - Circadian variations of prostaglandin E2 and F2 alpha release in the golden hamster retinaNuria de Zavalía
Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Departamento de Bioquimica Humana, Facultad de Medicina CEFyBO, Universidad de Buenos Aires CONICET, Buenos Aires, Argentina
J Neurochem 112:972-9. 2010..Thus, the present results suggest that the prostaglandin/COX-1 system could be a retinal clock output or part of the retinal clock mechanism... - Circadian and pharmacological regulation of casein kinase I in the hamster suprachiasmatic nucleusPatricia V Agostino
Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
J Genet 87:467-71. 2008.... - Diurnal variation in endotoxin-induced mortality in mice: correlation with proinflammatory factorsLuciano Marpegan
Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
Chronobiol Int 26:1430-42. 2009.... - Photic regulation of map kinase phosphatases MKP1/2 and MKP3 in the hamster suprachiasmatic nucleiGastón A Pizzio
Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Sáenz Peña 352 Bernal, B1876BXD, Buenos Aires, Argentina
J Mol Neurosci 34:187-92. 2008..These results show a different perspective on MAPKs in the SCN, which includes its regulation by a complex net of phosphatases... - Circadian rhythms in metabolic variables in Caenorhabditis elegansMaría Laura Migliori
Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina National Research Council CONICET, Argentina
Physiol Behav 103:315-20. 2011..elegans metabolic variables vary daily. In summary, our results will allow us to take full advantage of this widely used animal model (including research in genetics, ageing and developmental biology) for studies in Chronobiology... - Casein kinase-1-epsilon (CK1epsilon) and circadian photic responses in hamstersPatricia V Agostino
Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Buenos Aires, Argentina
Chronobiol Int 26:126-33. 2009..We now demonstrate that the mutation results in a heightened sensitivity to light, suggesting that CK1epsilon also regulates the photic entrainment pathway... - Extracellular nitric oxide signaling in the hamster biological clockSantiago A Plano
Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 352, Bernal B1876BXD, Buenos Aires, Argentina
FEBS Lett 581:5500-4. 2007..These results suggest that NO may act as an intercellular messenger in the SCN, mediating light-induced phase advances... - Circadian modulation of interval timing in micePatricia V Agostino
Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Buenos Aires, Argentina
Brain Res 1370:154-63. 2011..Taken together, our results indicate that short-time estimation is modulated by the circadian clock... - Circadian stress tolerance in adult Caenorhabditis elegansSergio H Simonetta
Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque S Peña 352, 1876, Bernal, Pcia de Buenos Aires, Argentina
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:821-8. 2008..This work demonstrates for the first time that in the adult nematode, C. elegans stress responses vary daily, and provides evidence of an underlying rhythmic gene expression that governs these behaviors... - Circadian variation in Pseudomonas fluorescens (CHA0)-mediated paralysis of Caenorhabditis elegansAndres Romanowski
Laboratory of Chronobiology, Dept of Science and Technology, National University of Quilmes, Buenos Aires, Argentina
Microb Pathog 50:23-30. 2011..The innate immune response to P. fluorescens CHA0 might depend on the stress response pathway of C. elegans. The fact that the tolerance varies daily gives further proof of an underlying clock that governs cyclic behavior in C. elegans... - An automated tracking system for Caenorhabditis elegans locomotor behavior and circadian studies applicationSergio H Simonetta
Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, National Research Council CONICET, R S Peña 352, B1876BXD Bernal, Buenos Aires, Argentina
J Neurosci Methods 161:273-80. 2007..44 h period (52% of significantly rhythmic animals) in LD, and a 23.1+/-0.40 h period (37.5% of significantly rhythmic animals) under DD. The system is automateable using microcontrollers, of low-cost construction and highly reproducible... - Forced desynchronization of activity rhythms in a model of chronic jet lag in miceLeandro P Casiraghi
Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Quilmes, Argentina
J Biol Rhythms 27:59-69. 2012.... - Disruption of Transitional Stages in 24-h Blood Pressure Recording in Renal Transplant RecipientsMarcelo E Katz
Department of Science and Technology, University of Quilmes Buenos Aires, Argentina
Front Neurol 3:35. 2012.... - Unwinding the molecular basis of interval and circadian timingPatricia V Agostino
Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes Buenos Aires, Argentina
Front Integr Neurosci 5:64. 2011..While there is currently no common neurochemical substrate for timing mechanisms in the brain, circadian modulation of interval timing suggests an interaction of different frequencies in cerebral temporal processes... - Diurnal variation in the proconvulsant effect of 3-mercaptopropionic acid and the anticonvulsant effect of androsterone in the Syrian hamsterGabriela Naum
CEI/Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, , Bernal (1876, Pcia. de Buenos Aires, Argentina
Life Sci 71:91-8. 2002..These results support the importance of temporal regulation of GABAergic modulation in the central nervous system... - Ghrelin effects on the circadian system of micePaola C Yannielli
Universidad Nacional de Quilmes Consejo Nacional de Investigaciones Científicas y Técnicas, Bernal, 1876 Buenos Aires, Argentina
J Neurosci 27:2890-5. 2007.... - Constitutive activation of the ERK-MAPK pathway in the suprachiasmatic nuclei inhibits circadian resettingErnesto C Hainich
, , 1876) Bernal Buenos Aires, Argentina
FEBS Lett 580:6665-8. 2006..Therefore, circadian regulation of the ERK pathway is not essential for the normal mechanism of the biological clock, but it is fundamental as an interface with environmental entrainment by light... - Blunting of circadian rhythms and increased acrophase variability in sleep-time hypertensive subjectsSantiago Perez-Lloret
Physiology Department, School of Medicine, University of Buenos Aires, Argentina
Chronobiol Int 25:99-113. 2008..Altogether, the findings suggest a disorganization of the BP circadian rhythm in sleep-time hypertensives that results in reduced 24 h rhythm amplitude and integrity that could be related to cardiovascular risk...