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| Juliana CassataroSummaryAffiliation: Universidad de Buenos Aires Country: Argentina Publications
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Publications
Immunogenicity of the Brucella melitensis recombinant ribosome recycling factor-homologous protein and its cDNAJuliana Cassataro
Facultad de Farmacia y Bioquimica, Instituto de Estudios de la Inmunidad Humoral IDEHU, Universidad de Buenos Aires UBA, Junin 956, 1113 Buenos Aires, Argentina
Vaccine 20:1660-9. 2002..melitensis. However, the potential of CP24 for a Brucella diagnostic test based on an in vitro antigen (Ag)-specific IFN-gamma production or DTH test would be worth testing...- Brucella outer membrane protein Omp31 is a haemin-binding proteinM Victoria Delpino
Instituto de Estudios de la Inmunidad Humoral (IDEHU, , Universidad de Buenos Aires (UBA, , 4to. piso, 1113 Buenos Aires, Argentina
Microbes Infect 8:1203-8. 2006..Overall, these results show that Omp31 from B. suis, B. melitensis and B. ovis is an HBP, whose expression seems to be induced by iron limitation... - Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infectionJuliana Cassataro
Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, UBA, Córdoba 2351 3 Piso Sala 4 1120, Buenos Aires, Argentina
Infect Immun 73:8079-88. 2005..melitensis but less protection than was induced by rOmp31 against B. ovis. Our results indicate that rOmp31 could be a useful candidate for the development of subunit vaccines against B. melitensis and B. ovis... - A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic responseJuliana Cassataro
Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina
Infect Immun 73:6537-46. 2005..The protective response could be related to the induction of CD8(+) T cells that eliminate Brucella-infected cells via the perforin pathway... - Improved immunogenicity of a vaccination regimen combining a DNA vaccine encoding Brucella melitensis outer membrane protein 31 (Omp31) and recombinant Omp31 boostingJuliana Cassataro
Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, UBA, Cordoba 2351, 3er Piso Sala 4, Buenos Aires, Argentina
Clin Vaccine Immunol 14:869-74. 2007..In conclusion, pCIOmp31 priming followed by rOmp31 boosting led to moderately improved protection against a challenge with B. ovis or B. melitensis... - A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccinationJuliana Cassataro
Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires UBA, Cordoba 2351, Buenos Aires, Argentina
Vaccine 25:4437-46. 2007.... - A DNA vaccine coding for the chimera BLSOmp31 induced a better degree of protection against B. ovis and a similar degree of protection against B. melitensis than Rev.1 vaccinationJuliana Cassataro
Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Vaccine 25:5958-67. 2007..Hitherto, this is the first indication that a recombinant subunit vaccine elicits greater protection than whole Brucella... - Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infectionKarina A Pasquevich
Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Córdoba 2351 3 Piso Sala 4 1120, Buenos Aires, Argentina
Infect Immun 77:436-45. 2009..Overall these results indicate that U-Omp16 or U-Omp19 would be a useful candidate for a subunit vaccine against human and animal brucellosis... - Brucella lumazine synthase elicits a mixed Th1-Th2 immune response and reduces infection in mice challenged with Brucella abortus 544 independently of the adjuvant formulation usedCarlos A Velikovsky
Instituto de Estudios de la Inmunidad Humoral (IDEHU, , Universidad de Buenos Aires, , 1113 Buenos Aires, Argentina
Infect Immun 71:5750-5. 2003.... - Brucella lipoproteins mimic dendritic cell maturation induced by Brucella abortusAstrid Zwerdling
Instituto de Estudios de la Inmunidad Humoral CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires U B A, Buenos Aires, Argentina
Microbes Infect 10:1346-54. 2008..These results demonstrate that B. abortus lipoproteins can stimulate DC maturation providing a mechanism by which these bacteria generate a Th1-type immune response... - Brucella abortus inhibits major histocompatibility complex class II expression and antigen processing through interleukin-6 secretion via Toll-like receptor 2Paula Barrionuevo
Instituto de Estudios de la Inmunidad Humoral IDEHU, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina
Infect Immun 76:250-62. 2008..Together, these results indicate that there is a mechanism by which B. abortus may prevent recognition by T cells to evade host immunity and establish a chronic infection... - Brucella abortus inhibits IFN-?-induced Fc?RI expression and Fc?RI-restricted phagocytosis via toll-like receptor 2 on human monocytes/macrophagesPaula Barrionuevo
Instituto de Estudios de la Inmunidad Humoral CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires UBA, Buenos Aires, Argentina
Microbes Infect 13:239-50. 2011..These results, together with our previous observations establish that B. abortus utilizes its lipoproteins to inhibit the monocytes/macrophages activation mediated by IFN-? and to subvert host immunonological responses... - An oral vaccine based on U-Omp19 induces protection against B. abortus mucosal challenge by inducing an adaptive IL-17 immune response in miceKarina A Pasquevich
Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
PLoS ONE 6:e16203. 2011..They also indicate different and important new aspects i) IL-17 does not contribute to reduce the bacterial burden in non vaccinated mice and ii) IL-17 plays a central role in vaccine mediated anti-Brucella mucosal immunity... - Antibody reactivity to Omp31 from Brucella melitensis in human and animal infections by smooth and rough BrucellaeJuliana Cassataro
, , Universidad de Buenos Aires, Buenos Aires, Argentina
Clin Diagn Lab Immunol 11:111-4. 2004..melitensis would be of limited value for the diagnosis of human and animal brucellosis. Nevertheless, the potential usefulness of this antigen in combination with other recombinant proteins from Brucella should not be dismissed... - Brucella abortus activates human neutrophilsAstrid Zwerdling
Instituto de Estudios de la Inmunidad Humoral CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires UBA, Buenos Aires, Argentina
Microbes Infect 11:689-97. 2009..Data presented here, together with our previous results implicate Brucella lipoproteins in the pathogenesis of human brucellosis... - Antibodies to the CP24 protein of Brucella melitensis lack diagnostic usefulness in ovine brucellosisM Victoria Delpino
Instituto de Estudios de la Inmunidad Humoral (IDEHU, , Universidad de Buenos Aires (UBA, , 1113, Buenos Aires, Argentina
Vet Microbiol 93:101-7. 2003..Sera from infected sheep were all positive for antibodies against lipopolysaccharides and lumazine synthase from Brucella. These results show that anti-CP24 antibodies have no diagnostic role in ovine brucellosis... - Vaccination with Brucella recombinant DnaK and SurA proteins induces protection against Brucella abortus infection in BALB/c miceMaria Victoria Delpino
Instituto de Estudios de la Inmunidad Humoral IDEHU CONICET, Facultad de Farmacia y Bioquimica, UBA, Buenos Aires, Argentina
Vaccine 25:6721-9. 2007..abortus strain 19 control vaccines. Altogether these results suggest that rSurA or rDnaK induce partial protection against B. abortus infection and could be useful candidates for the development of subunit vaccines against brucellosis... - A bile salt hydrolase of Brucella abortus contributes to the establishment of a successful infection through the oral route in miceM Victoria Delpino
Instituto de Estudios de la Inmunidad Humoral IDEHU, CONICET UBA, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina
Infect Immun 75:299-305. 2007..This study shows that CGH confers on Brucella the ability to resist the antimicrobial action of bile salts. The results also suggest that CGH may contribute to the ability of Brucella to infect the host through the oral route... - Diagnostic usefulness of antibodies against ribosome recycling factor from Brucella melitensis in human or canine brucellosisJuliana Cassataro
Instituto de Estudios de la Inmunidad Humoral (IDEHU, , Universidad de Buenos Aires, 1113 Buenos Aires, Argentina
Clin Diagn Lab Immunol 9:366-9. 2002..In the latter case, however, an ELISA combining CP24 and BLS is more sensitive than assays measuring anti-CP24 or anti-BLS antibodies separately and almost as sensitive as the ELISA using CP... - Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortusGuillermo H Giambartolomei
Instituto de Estudios de la Inmunidad Humoral Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
J Immunol 173:4635-42. 2004..We submit that LPS is not the cause of inflammation in brucellosis; rather, lipoproteins of this organism trigger the production of proinflammatory cytokines, and TLR2 is involved in this process... - The recombinant Omp31 from Brucella melitensis alone or associated with rough lipopolysaccharide induces protection against Brucella ovis infection in BALB/c miceSilvia M Estein
, Departamento de Sanidad Animal y Medicina Preventiva, Facultad de Ciencias Veterinarias, UNICEN, 7000 Tandil, Argentina
Microbes Infect 5:85-93. 2003..In conclusion, the recombinant Omp31 associated or not with B. ovis R-LPS, could be an interesting candidate for a subcellular vaccine against B. ovis infection... - A DNA vaccine encoding lumazine synthase from Brucella abortus induces protective immunity in BALB/c miceCarlos A Velikovsky
, UNICEN, Tandil, Argentina
Infect Immun 70:2507-11. 2002..Altogether, these data suggest that pcDNA-BLS is a good immunogen for the production of humoral and cell-mediated responses in mice and is a candidate for use in future studies of vaccination against brucellosis... - Immunogenicity of recombinant Omp31 from Brucella melitensis in rams and serum bactericidal activity against B. ovisSilvia M Estein
Laboratorio de Inmunoquimica y Biotecnologia, Departamento de Sanidad Animal y Medicina Preventiva, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, 7000 Tandil, Argentina
Vet Microbiol 102:203-13. 2004..Finally, immunized rams showed skin reactivity to Omp31. These data demonstrate that B. melitensis Omp31, a protective antigen identified in the mouse model, induces antibody and cellular immune mechanisms in sheep... - Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/Fas ligand cytotoxic pathwayRoxana Schillaci
Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas de Argentina, Vuelta de Obligado 2490, Buenos Aires C1428ADN, Argentina
J Immunol 176:3426-37. 2006..Immunization with these tumor immunogens imparted protection against parental tumor growth through activation of a specific immune response...